C. James

I argue that historical contingency, in the sense of the order in which events take place, can be an essential factor in determining which of two equally adequate and fruitful, but observationally indistinguishable, scientific theories is accepted by the scientific community. This type of actual underdetermination poses questions for scientific realism and for rational reconstruction in theory evaluation. To illustrate this, I discuss the complete observational equivalence of two radically different, conceptually incompatible interpretations of quantum mechanics and argue that an entirely plausible reordering of historical factors could reasonably have resulted in the causal program having been chosen over the "Copenhagen" one.

Infantile physical morphology—marked by its “cuteness”—is thought to be a potent elicitor of caregiving, yet little is known about how cuteness may shape immediate behavior. To examine the function of cuteness and its role in caregiving, the authors tested whether perceiving cuteness can enhance behavioral carefulness, which would facilitate caring for a small, delicate child. In 2 experiments, viewing very cute images (puppies and kittens)—as opposed to slightly cute images (dogs and cats)—led to superior performance on a subsequent fine-motor dexterity task (the children’s game “Operation”). This suggests that the human sensitivity to those possessing cute features may be an adaptation that facilitates caring..

Engaging young people in health research has been promoted globally. We explored the outcomes of youth advisory group on health and research engagement (YAGHRE) in rural Cambodia. In May 2021, the Mahidol Oxford Tropical Medicine Research Unit (MORU) partnered with a local health centre and a secondary school to establish a youth engagement group. Ten students underwent training and led health engagement activities in schools and communities. Activities were documented as field notes and audio-visual materials which underwent content analysis using theory of change supplemented by iterative discussions with YAGHRE members and stakeholders. Five major outcomes were identified: 1. Increased respect. Engagement activities developed based on input from students and stakeholders may have fostered greater respect. 2. Built trust and relationships. Frequent visits to MORU’s laboratory and interactions with researchers appeared to contribute to the building of trust and relationship. 3. Improved health and research literacy. Learning new health and research topics, through participatory activities may have improved literacy; 4. Improved uptake of health and research interventions. Health promotional activities and communication with research participants potentially increased the uptake of interventions; 5. Improved community health. YAGHRE’s health promotional interventions may have contributed in enhancing community’s health.

In this paper, I aim to shed light on the use of transcendental deductions, within demonstrations of aspects of Wittgenstein's early semantics, metaphysics, and philosophy of mathematics. I focus on two crucial claims introduced by Wittgenstein within these transcendental deductions, each identified in conversation with Desmond Lee in 1930-31. Specifically, the claims are of the logical independence of elementary propositions, and that infinity is a number. I show how these two, crucial claims are both demonstrated and subsequently deployed by Wittgenstein within a series of transcendental deductions, a series which begins with extensionalism as a generalized condition of sense on propositions, and in the context of which are then derived various, further, significant and unobvious presuppositions generated by that generalized condition of sense. In addition to clearing up deductions of these two, aforementioned claims, I also elucidate deductions of the subsistence of objects, and of logical space as an infinite totality.

Policies allowing some minors to consent to receive recommended vaccines are ethically defensible. However, a policy change at the federal level expanding minor consent for vaccinations nationwide risks triggering a political backlash. Such a move may be perceived as infringing on the rights of parents to make decisions about their children’s health care. In the current post-COVID environment of heightened anti-vaccination activism, changes to minor consent laws may be unadvisable, and policy makers should proceed with caution.

Aworkshop was held August 26–28, 2015, by the Earth- Life Science Institute (ELSI) Origins Network (EON, see Appendix I) at the Tokyo Institute of Technology. This meeting gathered a diverse group of around 40 scholars researching the origins of life (OoL) from various perspectives with the intent to find common ground, identify key questions and investigations for progress, and guide EON by suggesting a roadmap of activities. Specific challenges that the attendees were encouraged to address included the following: What key questions, ideas, and investigations should the OoL research community address in the near and long term? How can this community better organize itself and prioritize its efforts? What roles can particular subfields play, and what can ELSI and EON do to facilitate research progress? (See also Appendix II.) The present document is a product of that workshop; a white paper that serves as a record of the discussion that took place and a guide and stimulus to the solution of the most urgent and important issues in the study of the OoL. This paper is not intended to be comprehensive or a balanced representation of the opinions of the entire OoL research community. It is intended to present a number of important position statements that contain many aspirational goals and suggestions as to how progress can be made in understanding the OoL. The key role played in the field by current societies and recurring meetings over the past many decades is fully acknowledged, including the International Society for the Study of the Origin of Life (ISSOL) and its official journal Origins of Life and Evolution of Biospheres, as well as the International Society for Artificial Life (ISAL).

Neural organoids are laboratory-generated entities that replicate certain structural and functional features of the human brain. Most neural organoids are disembodied—completely decoupled from sensory input and motor output. As such, questions about their potential capacity for consciousness are exceptionally difficult to answer. While not disputing the need for caution regarding certain neural organoid types, this paper appeals to two broad constraints on any adequate theory of consciousness—the first involving the dependence of consciousness on embodiment; the second involving the dependence of consciousness on representations—to argue that disembodied neural organoids are not plausible candidates for consciousness.

A single protein molecule with one or more cysteine residues can occupy a plurality of unique residue and oxidation‐chemotype specified proteoforms that I term oxiforms. In binary reduced or oxidised terms, one molecule with three cysteines will adopt one of eight unique oxiforms. Residue‐defined sulfur chemistry endows specific oxiforms with distinct functionally‐relevant biophysical properties (e.g., steric effects). Their emergent complexity means a functionally‐relevant effect may only manifest when multiple cysteines are oxidised. Like how mixing colours makes new shades, combining discrete redox chemistries—colours—can create a kaleidoscope of oxiform hues. The sheer diversity of oxiforms co‐existing within the human body provides a biological basis for redox heterogeneity. Of evolutionary significance, oxiforms may enable individual cells to mount a broad spectrum of responses to the same stimulus. Their biological significance, however plausible, is speculative because protein‐specific oxiforms remain essentially unexplored. Excitingly, pioneering new techniques can push the field into uncharted territory by quantifying oxiforms. The oxiform concept can advance our understanding of redox‐regulation in health and disease.

In _Experience and Judgment, _Husserl explores the problems of contemporary philosophy of language and the constitution of logical forms. He argues that, even at its most abstract, logic demands an underlying theory of experience. Husserl sketches out a genealogy of logic in three parts: Part I examines prepredicative experience, Part II the structure of predicative thought as such, and Part III the origin of general conceptual thought. This volume provides an articulate restatement of many of the themes of Husserlian phenomenology

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_From Soul to Self_ takes the reader on a fascinating journey through philosophy, theology, religious studies, and physiological sciences. Each of the essays, drawn from a number of different fields, focuses on the idea of the soul and of our sense of ourselves. A stellar line-up of authors explore the relationship between a variety of ideas that have arisen in philosophy, religion and science, each idea seeking to explain why we think that we as individuals are somehow distinct and unique. Contributors: Richard Sorabji, Anthony Kenny, Kallistos Ware, Peter Riviere, Gary Matthews, Susan Greenfield, Galen Strawson

The increasing secularization of political thought between the mid-seventeenth and mid-nineteenth centuries has often been noted, but rarely described in detail. The contributors to this volume consider the significance of the relationship between religious beliefs, dogma and secular ideas in British political philosophy from Thomas Hobbes to J.S. Mill. During this period, Britain experienced the advance of natural science, the spread of education and other social improvements, and reforms in the political realm. These changes forced religion to account for itself and to justify its existence, both as a social institution and as a collection of fundamental articles of belief about the world and its operations. This book, originally published in 1990, conveys the crucial importance of the association between religion, secularization and political thought

In the recent philosophy of science literature, several authors have stressed the many-faceted and evolving nature of the scientific enterprise. Dudley Shapere (1984, pp. xiii-xv) characterizes a central weakness of the logical empirical program as its focus on the formal logical structure of scientific theories to the exclusion of the process by which these theories were constructed, thus ignoring the possibility of fundamental changes in the nature of science itself. He has stressed the importance of formulating a view of science based on an accurate description of actual scientific practice, which includes attention to how the meaning of a scientific term is rooted in this evolving matrix of practice. Janet Kourany (1982) has attempted” …to lay the foundations for a purely empirical method for establishing a theory of science” (p. 526). In arguing that the a priori has no place in such an approach and in responding to the charge that such an empirical method cannot produce an absolutely fixed set of criteria, Kourany (p. 546) reminds us of Popper’s observation about another empirical enterprise and suggests that we apply this same admonition to our expectations for an empirical method of constructing a theory of science itself.

This book focuses on how and why various cultures have appropriated the story of King Arthur. It is about re-vision, how cultures alter inherited texts and are, in turn, changed by them, and it deals with the ways in which various cultures have empowered the Arthurian legend so that power might be derived from it. The authors suggest that the vitality of the Arthurian legend resides in its ability to be transformed and to transform, in its potential for appropriation and use. Culture and the King deals with issues of literature, history, art, politics, economics, gender study, and popular culture. It crosses the boundaries traditionally erected around these disciplines and addresses emerging critical methodologies concerned with the "poetics of culture."