Wei Wang

Physical forces regulate numerous biological processes during development, physiology, and pathology. Forces between the external environment and intracellular actin cytoskeleton are primarily transmitted through integrin‐containing focal adhesions and cadherin‐containing adherens junctions. Crosstalk between these complexes is well established and modulates the mechanical landscape of the cell. However, integrins and cadherins constitute large families of adhesion receptors and form multiple complexes by interacting with different ligands, adaptor proteins, and cytoskeletal filaments. Recent findings indicate that integrin‐containing hemidesmosomes oppose force transduction and traction force generation by focal adhesions. The cytolinker plectin mediates this crosstalk by coupling intermediate filaments to the actin cytoskeleton. Similarly, cadherins in desmosomes might modulate force generation by adherens junctions. Moreover, mechanotransduction can be influenced by podosomes, clathrin lattices, and tetraspanin‐enriched microdomains. This review discusses mechanotransduction by multiple integrin‐ and cadherin‐based cell adhesion complexes, which together with the associated cytoskeleton form an integrated network that allows cells to sense, process, and respond to their physical environment.

The epistemological version of structural realism, proposed by Cao Tianyu, has great influence in the philosophy of science. Syntheses has published a special volume discussing the topic. Cao criticizes anti-realism, as well as the epistemic and ontic versions of structural realism. From the concepts of structure, ontology, and construction, he analyzes the objectivity of scientific theories as having five aspects: construction, historicity, holism, revision, and revolution. This paper systematically analyzes and comments on Cao's structural realism. The author agrees with his criticism of the under-determination thesis, is neutral to his argument against ontological discontinuity, and questions his universal language argument. /// 曹天予提出的结构实在论知识论版本在科学哲学界有很大影响，并引发了《综 合》期刊专刊讨论。他既批评反实在论的观点，也对结构实在论的知识版本与本体 版本有所批判。他从结构、本体、建构这三个概念出发，论证了科学理论的客观性 体现为建构性、历史性、整体性、修正性、革命性。本文对曹天予的结构实在论进 行了系统的梳理与分析，赞同他对"不充分决定"论旨的批评，对他批评"本体论 不连续性"持中立态度，但对他的"普遍语法论证"有所存疑。.

The epistemological version of structural realism, proposed by Cao Tianyu, has great influence in the philosophy of science. Syntheses has published a special volume discussing the topic. Cao criticizes anti-realism, as well as the epistemic and ontic versions of structural realism. From the concepts of structure, ontology, and construction, he analyzes the objectivity of scientific theories as having five aspects: construction, historicity, holism, revision, and revolution. This paper systematically analyzes and comments on Cao's structural realism. The author agrees with his criticism of the under-determination thesis, is neutral to his argument against ontological discontinuity, and questions his universal language argument.

The book is a translation of the second edition of a much-used and research-based Chinese textbook. As a succinct and issue-based introduction to the Western philosophy of science, the book brings eight focal issues in the field to the fore and offers a helpful addition to the topics by incorporating Chinese perspectives on these issues. Followed by an overview of the historical framework and logical underpinnings of philosophy of science, the book thoroughly discusses eight issues in the discipline: (1) the criteria of cognitive meaning, (2) induction and confirmation, (3) scientific explanation, (4) theories of scientific growth, (5) demarcation between science and pseudoscience, (6) scientific realism and empiricism; (7) philosophy of scientific experimentation, (8) science and value. Not confined to Western mainstream discourse in this field, the book also introduces voices of Chinese philosophers of note and adopts a stance productively combining logical empiricism and Kuhnianism, both of which are underrated by a host of English textbooks. In the final chapter the author offers a prognosis regarding the future of the discipline based on recent trends. This book will be valued by students who study philosophy of science and hope to gain a better understanding of science and technology.

ObjectiveTo explore the relations among perceived stress, fatigue, sleepiness, and the pathway of their effects on the ambulatory arterial stiffness index among medical staff.MethodsThis cross-sectional study was conducted at a tertiary hospital in Wuhan, China. Perceived stress, fatigue, and sleepiness were measured using the perceived stress scale, Fatigue assessment scale, and Epworth Sleepiness Scale, respectively. AASI was obtained from 24-h ambulatory blood pressure monitoring. Path analysis was used to clarify the relations among the PSS, FAS, and ESS scores, and their relations to AASI values.ResultsA total of 153 participants were included herein. The PSS and FAS correlated with the ESS, and the PSS correlated with the FAS. In addition, the ESS correlated with the AASI. According to the path analysis results, the PSS and FAS had no direct effect on the AASI, but did have an indirect effect on this index by influencing the ESS.ConclusionSleepiness was a mediator of the effects of perceived stress and fatigue on AASI.

As the sensitivity to corporate social responsibility continues to grow, the goal of enterprises has expanded beyond the sole pursuit of economic value. Corporate social goal orientation has therefore come to occupy a central position in entrepreneurs’ psychology and the transition away from a market-only economy. This study uses secondary data from 4,288 samples of 725 Chinese-listed companies from 2009 to 2020 to explore the driving factors in social goal orientation based on the characteristics of sample companies and their industry groups from the perspective of stakeholder relationships. The results can be summarized as follows: there is an inverted U-shaped relationship between government stakeholder relationships and social goal orientation, and there is a significant positive relationship between financial stakeholder relationships, market stakeholder relationships, and corporate social goal orientation. The correlation between single-dual stakeholder relationships and social goal orientation is not consistent. In light of the nature of the roles of government and the market, the correlation between the government–market dual relationship and corporate social goal orientation is not significant. However, there is a significant correlation between the finance–government dual stakeholder relationship and social goal orientation; that is, the dual stakeholder relationship maintains the existence of non-institutional capital and corporate financial capital. Moreover, there is no significant correlation between the market–finance dual relationship and corporate social goal orientation, and there is substitutability between market and financial stakeholder relationships. With the deepening of our understanding of CSR, the core goal of enterprises is no longer confined to the pursuit of economic value, and their social goal orientation has come to be regarded as a major driving force in sustainable development. This study enriches the research on the relationship between stakeholder relationships and shows that stakeholder relationships also have important significance to both achieving corporate goals and shaping entrepreneurs’ psychology.

As a mixed-methods research in economics and psychology, this study aimed to analyze the influence from the intergenerational succession on the financialization level including asset financialization and revenue financialization, and further test the moderating effect of the heirs’ typical growing experience according to The Imprinting Theory, based on the 2009–2020 annual data of listed family enterprises of China. There were two key findings. First, the effect of Chinese family enterprises’ intergenerational succession on asset financialization was positively significant while the effect on revenue financialization was not significant, indicating that the financialization behavior has not brought about effective financial profits. Second, among the heirs’ typical growing experiences, their parents’ entrepreneurial experience during their childhood, oversea study experience, and MBA education experience had the significantly positive moderating effects on the influence from intergeneration succession to asset financialization level of Chinese family enterprises, which was an important internal mechanism for the heirs to promote the financialization process of family enterprises.

The green economy is essential in supporting sustainable economic development and relies on talents and technologies. From the perspective of traditional economic theory, this study explores the impact of high-speed rail and innovation on the green economy from the perspectives of talent and technology. Using the data of 281 prefecture-level cities in China from 2008 to 2018, this study constructs empirical models to discuss the driving factors of the green economy. Empirical results show that high-speed rail and innovation can promote the development of a green economy, and the opening of high-speed rail can strengthen the positive association between innovation and a green economy. The accessibility of high-speed rail improves the flow of talent between different cities and greatly stimulates the positive impact of innovation on green economic activities. In the further test, this study explores the impact of high-speed rail and innovation on the green economy from different dimensions, including government policy, economic strength, and administrative level. During China’s 12th Five-Year Plan, high-speed rail and innovation had a positive impact on the green economy, but the impact of innovation can still be significant after this period. Moreover, the opening of high-speed rail may motivate the migration of talents from developed cities to developing ones, while developed cities can rely on technological advantages to support green economic activities. Furthermore, low-administrative level cities will rely on attracting more talents to promote a green economy due to technological disadvantages. Innovation can play a critical role in enhancing the green economy of cities with high administrative levels. Talents and technology are both important to green economic activities, and the construction of high-speed rail changes the impact of technology on the green economy through the flow of talent. Our findings can explain why the opening of high-speed rail can promote the development of a green economy and effectively help governments achieve the goal of sustainable development.

Workplace incivility remains a prevailing issue and has significant potential for harmful consequences. This study aims to investigate the influencing mechanism of workplace incivility on work alienation from the perspective of targets. Based on the social exchange theory, our research examines the role of interpersonal trust as a mediator along with the moderator of career resilience in the said association. Through a two-wave-time-lagged quantitative research design, a sample of 315 nurses from China was investigated with questionnaires on workplace incivility, work alienation, interpersonal trust, and career resilience. The results indicated that workplace incivility was positively related to work alienation with interpersonal trust as a mediator. Workplace incivility caused a decline in interpersonal trust, which led to work alienation. Career resilience buffered such an impact. High career resilience weakened the association linking workplace incivility to interpersonal trust. Organizations should pay more attention to workplace incivility and consider empowering nurses’ career resilience, which could alleviate the negative impact of workplace incivility.

Vitiligo is a common depigmenting skin disease with profound psychosocial impacts. Depression is one of the most common mental distress. Social support has a significant impact on the psychological status of patients. The aim of this study is to investigate the depression and social support status of patients with vitiligo in China, and further explore the correlation between social support and depression. The outpatients with vitiligo were investigated face to face with SDS and SSRS. The mean SDS score of the patients was 44.05 ± 6.76, which was significantly higher than Chinese norms. Female patients, unmarried, disease at rapid progressive stage and skin lesions at the exposed site had higher SDS scores. The scores of total social support, subjective support, objective support and support availability were lower than Chinese norms, and all were negatively correlated with SDS scores. In conclusion, low social support is one of the risk factors for depression in patients with vitiligo in China. More support and acceptance should be given to the patients.

The influence of attachment style—anxious and avoidant attachment—on subjective responses to socially excluded experiences termed “Need-Threat” remains inconsistent. Need-Threat is a composite score of four fundamental needs: belonging, self-esteem, control, and meaningful existence. Individuals with high AX tend to spend much effort maintaining strong connections with others, while those with high AV tend to maintain high levels of self-esteem by distancing themselves from others. Therefore, attachment style is most likely to influence the need associated with each style. In addition, since individuals with high AV satisfy their needs by keeping independence from others, they would experience the Need-Threat against excessive inclusion from others. This study aimed to investigate the influence of attachment style on each Need-Threat response to various inclusionary statuses. A total of 133 undergraduate students were equally assigned to low or high groups for each attachment style. Participants played one of the three types of the cyberball task : excluded, included, or over-included situation. The high AV group felt fewer threats to self-esteem than the low AV group in the excluded situation. Furthermore, only in the over-included situation did the high AV group feel more threats to belonging and self-esteem than the low AV group. AX did not influence any situation. These findings suggest that individuals with high AV would have a restrictive alleviation effect on adverse subjective responses to socially excluded experiences but demonstrate maladaptive subjective responses to over-included experiences.

The enterprise network is of great significance in explaining the risk-taking of individual firm. However, some unobservable networks hidden in different firms have long been neglected. Using the text data of the annual reports of China’s listed firms from 2007 to 2018, this paper adopts a textual analysis method to capture the managers’ perceptions of pressure, and build a special kind of hidden inter-firm networks, that is, the perceived competition networks of managers. In addition, this paper discusses the impact of network characteristics on corporate risk-taking behavior. Empirically, there is a positive association between competition strength and corporate risk-taking, as well as the density of perceived competition network. Furthermore, this paper explores the risk-taking behaviors of peer firms in focal firm’s perceived competition network, and finds that the improvement of peer firms’ risk-taking significantly increases the risk bearing level of focal firm, that is, the positive spillover effect of risk-taking behavior among firms in perceived competition networks. Moreover, managers’ personal traits significantly moderate the impact of network characteristics on corporate risk-taking, which is mainly reflected in younger and male managers. Our findings can enrich the literature on social interactions and corporate behaviors, and help firms to improve their understanding of perceptible peer firms.

In order to solve the problem of unsmooth and inefficient human-computer interaction process in the information age, a method for human-computer interaction intention prediction based on electroencephalograph signals and eye movement signals is proposed. This approach is different from previous methods where researchers predict using data from human-computer interaction and a single physiological signal. This method uses the eye movements and EEG signals that clearly characterized the interaction intention as the prediction basis. In addition, this approach is not only tested with multiple human-computer interaction intentions, but also takes into account the operator in different cognitive states. The experimental results show that this method has some advantages over the methods proposed by other researchers. In Experiment 1, using the eye movement signal fixation point abscissa Position X, fixation point ordinate Position Y, and saccade amplitude to judge the interaction intention, the accuracy reached 92%, In experiment 2, only relying on the pupil diameter, pupil size and fixed time, fixed time of eye movement signals can not achieve higher accuracy of the operator’s cognitive state, so EEG signals are added. The cognitive state was identified separately by combining the screened EEG parameters Rα/β with the eye movement signal pupil diameter and fixation time, with an accuracy of 91.67%. The experimental combination of eye movement and EEG signal features can be used to predict the operator’s interaction intention and cognitive state.

BackgroundChildhood experiences can exert a huge impact on adult psychological conditions. Previous studies have confirmed the effects of adverse childhood experiences and benevolent childhood experiences on psychological distress separately, but few studies explored a combined effect of ACEs and BCEs on psychological distress. The aim of this study was to explore a combined effect of ACEs and BCEs on psychological distress among Chinese undergraduates.MethodsParticipants were undergraduates aged 17–24 years and completed a self-reported questionnaire. A series of regression analyses were conducted to examine the association between childhood experiences and psychological distress.ResultsA total of 65.7% of undergraduates had BCEs, 27.1% of undergraduates had ACEs, and 12.9% of undergraduates had ACEs and BCEs simultaneously. Logistic regression analysis indicated that undergraduates who experienced high ACEs were more likely to have a high risk of psychological distress [odds ratio = 1.46, 1.84, and 3.15 for uncertainty stress, depressive symptoms, and suicidal ideation, respectively], while undergraduates who experienced High BCEs were less likely to have psychological distress compared with Low-Both group. The combined effect of ACEs and BCEs could also play as a protective factor in uncertainty stress and depressive symptoms.ConclusionOur findings suggested that ACEs and BCEs could not only predict the psychological distress independently, but also BCEs could counteract the negative effect of ACEs in psychological problems. There is an even greater need to identify and support the victims of ACEs and to increase BCEs in early childhood.

The multicultural characteristics of students belonging to ethnic minorities in China pose challenges for teachers. Teacher competence in dealing with culturally diverse students has been extensively discussed in international scholarship and referenced by Chinese researchers, but there is limited empirical research on how teacher education programmes in China respond to this challenge and theoretical discussions. Based on content analysis on teacher education programmes and syllabuses, as well as expert interviews with four teacher educators at two teacher education institutions, this study investigates how the cultivation of multicultural competence is incorporated into teacher education programmes, and the external forces that shape it. Drawing on international scholarship on teachers’ multicultural competence and Cochran-Smith’s framework on external forces influencing multicultural teacher education practices, I argue that the cultivation of teachers’ multicultural competence for their future work in ethnic minority education is, to a great extent, missing from teacher education programmes. Furthermore, what pre-service teachers’ competence covers, and the external forces that influence how teacher education plays out in practice, are influenced and somewhat determined by the large social, economic and political context as well as the agenda for educational reform in China.

This study aimed to explore the effect of parents’ education anxiety on children’s academic burnout, and the mediation effect of parental burnout and the moderating effect of family function. A total of 259 paired parents and children from two middle schools in central China participated in the survey. The questionnaire was conducted using the Educational Anxiety Scale, Parental Burnout Scale, Adolescent Student Burnout Inventory, and Family APGAR Index. Our results indicated that parental education anxiety had a positive predictive effect on children’s academic burnout. Moreover, parental burnout played a complete mediating role between parents’ education anxiety and children’s academic burnout. Finally, the relationship between education anxiety and parental burnout was moderated by family function, and higher family function buffered the effect of education anxiety on parental burnout. The results suggest the mechanism of parental education anxiety on children’s academic burnout, and the role of family function in alleviating parental burnout.