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2INTRODUCTION: We have previously shown that a tag single nucleotide polymorphism, which maps to the CYP3A locus, was associated with a reduction in premenopausal urinary estrone glucuronide levels and a modest reduction in risk of breast cancer in women age ≤50 years.METHODS: We further investigated the association of rs10235235 with breast cancer risk in a large case control study of 47,346 cases and 47,570 controls from 52 studies participating in the Breast Cancer Association Consortium. Geno…Read more
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2© 2014 Johnson et al.Introduction: We have previously shown that a tag single nucleotide polymorphism, which maps to the CYP3A locus, was associated with a reduction in premenopausal urinary estrone glucuronide levels and a modest reduction in risk of breast cancer in women age ≤50 years. Methods: We further investigated the association of rs10235235 with breast cancer risk in a large case control study of 47,346 cases and 47,570 controls from 52 studies participating in the Breast Cancer Associ…Read more
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