Ioannis G. Ntagkas

Melinda Fagan’s book on the philosophy of stem cell biology is a superb discussion of this exciting field of contemporary science, and the first book-length philosophical treatment of the subject. It contains a detailed and insightful examination of stem cell science, its structure, methods, and challenges.The book does not require any previous knowledge of stem cell biology—all the relevant scientific details and concepts, the central experimental procedures and results, as well as the historical development of the field, are presented in as clear and accessible a way as possible. The presentation of the science starts in Chapter 1, with a general characterisation of stem cell biology, and continues throughout the book, with every chapter deepening and complicating the initial picture. Fagan’s lucid style makes even the more technical and detailed discussions of the research on human embryonic stem cells and on blood stem cells easy to follow.After the first in ..

In this paper we offer a minimal characterisation of the concept of mechanism in biomedicine, according to which a mechanism is a theoretically described causal pathway. We argue that this conceptionan be drawn from scientific practice, as illustrated by how a central biological and biomedical mechanism, the mechanism of apoptosis, was first identified and characterised. We will use the example of cytological and biochemical theoretical descriptions of the mechanism of apoptosis to draw lessons about the meaning of the concept of mechanism in biomedical contexts and to contrast our preferred account of mechanism with some prominent accounts within the philosophical literature. The main outcome of our discussion will be that commitment to mechanism is first and foremost a methodological stance.

Rani Lill Anjum and Stephen Mumford have recently defended a new kind of modality, which they call ‘dispositional modality’. The key reason to adopt dispositional modality, according to them, is that causes never necessitate their effects. Anjum and Mumford’s chief argument against causal necessitation makes use of what they call the ‘antecedent-strengthening test’ : C causally necessitates E iff C & φ causes E, for any possible φ. This test, they claim, fails in all cases of alleged causal necessitation. In this paper we argue that the AS-test is not the mark of causal necessitation. First, we show that if the AS-test is taken as the mark of causal necessitation it leads to either an absurdity or to circularity. Second, we argue that, given the Mill/Mackie framework of causes as INUS conditions, apparent counterexamples to causal necessitation fail.

Contemporary scientific perspectivism is primarily viewed as a methodological framework of how we obtain and form scientific knowledge of nature, through a broadly perspectivist process, especially, with reference to quantum mechanics. In the present study, this is implemented by representing categorically the global structure of a quantum algebra of events in terms of structured interconnected families of local Boolean probing frames, realized as suitable perspectives or contexts for measuring physical quantities. The essential philosophical meaning of the proposed approach implies that the quantum world can be consistently approached and comprehended through a multilevel structure of locally variable perspectives, which interlock, in a category-theoretical environment, to form a coherent picture of the whole in a non-trivial way.

[ES] Confronta ciertos enigmas surgidos en torno a la naturaleza e identidad de la obra musical, y rechaza estos enigmas por irreales: o bien ellos conciernen a la obra musical en sí misma, en cuyo caso son enigmas acerca del estatus metafísico de un objeto intencional, y por lo tanto susceptibles a una solución arbitraria, o bien ellos conciernen a los sonidos con los que la obra es escuchada, en cuyo caso simplemente se trata de casos especiales de los problemas concernientes a la naturaleza e identidad de los eventos. [EN] Confronts certain puzzles raised about the nature and identity of the musical work, and dismisses these puzzles as unreal: either they concern the musical work itself, in which case they are puzzles about the metaphysical status of an intentional object, and therefore susceptible to an arbitrary solution, or they concern the sounds in which the work is heard, in which case they are simply special cases of the problems concerning the nature and identity of events.

This book introduces a new approach to the issue of radical scientific revolutions, or "paradigm-shifts," given prominence in the work of Thomas Kuhn. The book articulates a dynamical and historicized version of the conception of scientific a priori principles first developed by the philosopher Immanuel Kant. This approach defends the Enlightenment ideal of scientific objectivity and universality while simultaneously doing justice to the revolutionary changes within the sciences that have since undermined Kant's original defense of this ideal. Through a modified Kantian approach to epistemology and philosophy of science, this book opposes both Quinean naturalistic holism and the post-Kuhnian conceptual relativism that has dominated recent literature in science studies. Focussing on the development of "scientific philosophy" from Kant to Rudolf Carnap, along with the parallel developments taking place in the sciences during the same period, the author articulates a new dynamical conception of relativized a priori principles. This idea applied within the physical sciences aims to show that rational intersubjective consensus is intricately preserved across radical scientific revolutions or "paradigm-shifts and how this is achieved.

Human beings are peculiar. In laboratory experiments, they often cooperate in one-shot prisoners’ dilemmas, they frequently offer 1/2 and reject low offers in the ultimatum game, and they often bid 1/2 in the game of divide-the-cake All these behaviors are puzzling from the point of view of game theory. The first two are irrational, if utility is measured in a certain way.1 The last isn’t positively irrational, but it is no more rational than other possible actions, since there are infinitely many other Nash equilibria besides the one in which both players bid 1/2. At the same time, these behaviors seem to indicate that people are sometimes inclined to be cooperative, fair, and just. In his stimulating new book, Brian Skyrms sets himself the task of showing why these inclinations evolved, or how they might have evolved, under the pressure of natural selection. The goal is not to justify our ethical intuitions, but to explain why we have them.2..

There are many things—call them ‘experts’—that you should defer to in forming your opinions. The trouble is, many experts are modest: they’re less than certain that they are worthy of deference. When this happens, the standard theories of deference break down: the most popular (“Reflection”-style) principles collapse to inconsistency, while their most popular (“New-Reflection”-style) variants allow you to defer to someone while regarding them as an anti-expert. We propose a middle way: deferring to someone involves preferring to make any decision using their opinions instead of your own. In a slogan, deferring opinions is deferring decisions. Generalizing the proposal of Dorst (2020a), we first formulate a new principle that shows exactly how your opinions must relate to an expert’s for this to be so. We then build off the results of Levinstein (2019) and Campbell-Moore (2020) to show that this principle is also equivalent to the constraint that you must always expect the expert’s estimates to be more accurate than your own. Finally, we characterize the conditions an expert’s opinions must meet to be worthy of deference in this sense, showing how they sit naturally between the too-strong constraints of Reflection and the too-weak constraints of New Reflection.

This article develops an axiomatic theory of induction that speaks to the recent debate on Bayesian orgulity. It shows the exact principles associated with the belief that data can corroborate universal laws. We identify two types of disbelief about induction: skepticism that the existence of universal laws of nature can be determined empirically, and skepticism that the true law of nature, if it exists, can be successfully identified. We formalize and characterize these two dispositions toward induction by introducing novel axioms for subjective probabilities. We also relate these dispositions to the axiom of σ-additivity.

In this paper, I reconstruct an argument of Aristidis Arageorgis against empirical underdetermination of the state of a physical system in a C*-algebraic setting and explore its soundness. The argument, aiming against algebraic imperialism, the operationalist attitude which characterized the first steps of Algebraic Quantum Field Theory, is based on two topological properties of the state space: being T1 and being first countable in the weak*-topology. The first property is possessed trivially by the state space while the latter is highly non-trivial, and it can be derived from the assumption of the algebra of observables’ separability. I present some cases of classical and of quantum systems which satisfy the separability condition, and others which do not, and relate these facts to the dimension of the algebra and to whether it is a von Neumann algebra. Namely, I show that while in the case of finite-dimensional algebras of observables the argument is conclusive, in the case of infinite-dimensional von Neumann algebras it is not. In addition, there are cases of infinite-dimensional quasilocal algebras in which the argument is conclusive. Finally, I discuss Porrmann's construction of a net of local separable algebras in Minkowski spacetime which satisfies the basic postulates of Algebraic Quantum Field Theory.

The work of women philosophers in the early modern period has traditionally been overlooked, yet their writing on topics such as reality, time, mind and matter holds valuable lessons for our understanding of metaphysics and its history. This volume of new essays explores the work of nine key female figures: Bathsua Makin, Anna Maria van Schurman, Elisabeth of Bohemia, Margaret Cavendish, Anne Conway, Damaris Cudworth Masham, Mary Astell, Catharine Trotter Cockburn, and Émilie Du Châtelet. Investigating issues from eternity to free will and from body to natural laws, the essays uncover long-neglected perspectives and demonstrate their importance for philosophical debates, both then and now. Combining careful philosophical analysis with discussion of the intellectual and historical context of each thinker, they will set the agenda for future enquiry and will appeal to scholars and students of the history of metaphysics, science, religion and feminism.

What is the aim of philosophy? There may be too many philosophical branches, traditions, practices, and programs to admit of a single overarching aim. Here I focus on a fairly traditional philosophical project that has recently received increasingly sophisticated articulation, especially by Frank Jackson (1998) and David Chalmers (2012). In §1, I present the project and suggest that it is usefully thought of as ‘total axiomatics’: the project of attempting to axiomatize the total theory of the world. In §2, I raise a problem for the project that I call the ‘problem of multiple axiomatizations.’ I consider some initially alluring but ultimately unpromising approaches to this problem in §3. In §4, I defend a surprising approach to the problem, according to which competing axiomatizations of the total theory of the world are effectively evaluated for their aesthetic virtues.

Suppose the only difference between the effects of two actions is to whom they apply: either to parties who would -- or would not -- exist if the actions were not performed. Is this a morally significant difference? This is one of the central questions raised by the Non-Identity Problem. Derek Parfit answers no, defending what he calls the ‘No-Difference View’. I argue that Parfit is mistaken and that sometimes this difference is morally significant. I do this by formulating a familiar kind of example in a new way. I make use of some findings in social psychology to help deflect counterexamples to my view. I then show how my view withstands Parfit's latest argument in favour of the No-Difference View. I conclude with a brief discussion of some questions my argument raises for consequentialist moral theory

This article suggests that scientific philosophy, especially mathematical philosophy, might be one important way of doing philosophy in the future. Along the way, the article distinguishes between different types of scientific philosophy; it mentions some of the scientific methods that can serve philosophers; it aims to undermine some worries about mathematical philosophy; and it tries to make clear why in certain cases the application of mathematical methods is necessary for philosophical progress

Empirical philosophers of science aim to base their philosophical theories on observations of scientific practice. But since there is far too much science to observe it all, how can we form and test hypotheses about science that are sufficiently rigorous and broad in scope, while avoiding the pitfalls of bias and subjectivity in our methods? Part of the answer, we claim, lies in the computational tools of the digital humanities, which allow us to analyze large volumes of scientific literature. Here we advocate for the use of these methods by addressing a number of large-scale, justificatory concerns—specifically, about the epistemic value of journal articles as evidence for what happens elsewhere in science, and about the ability of DH tools to extract this evidence. Far from ignoring the gap between scientific literature and the rest of scientific practice, effective use of DH tools requires critical reflection about these relationships.

ABSTRACT The target article uses the metaphysics of properties to make its meta-ethical claims. This comment discusses two general points in the metaphysics of properties. The first point has to do with the conditions for property identity. Philosophers who accept the existence of properties have proposed a variety of criteria for their identity. The standard Broome applies is medium coarse. Other standards for property identity could be evaluated for their appropriateness for addressing questions in the metaphysics of ethics. Use of a formalized theory of properties might help in such an evaluation. The second point has to do with Broome’s suggestion of a distinction between a property and a reified property. A suggestion will be offered for a range of ways such a distinction could be filled out using the resources of a formalized theory of properties and objects. Objects will be proposed that could serve as Broome’s reified properties.

The authors investigated the ontological argument computationally. The premises and conclusion of the argument are represented in the syntax understood by the automated reasoning engine PROVER9. Using the logic of definite descriptions, the authors developed a valid representation of the argument that required three non-logical premises. PROVER9, however, discovered a simpler valid argument for God's existence from a single non-logical premise. Reducing the argument to one non-logical premise brings the investigation of the soundness of the argument into better focus. Also, the simpler representation of the argument brings out clearly how the ontological argument constitutes an early example of a ‘diagonal argument’ and, moreover, one used to establish a positive conclusion rather than a paradox.

I propose a straightforward reconciliation of Leibniz’s conception of bodies as aggregates of simple substances (i.e., monads) with his doctrine that bodies are the phenomena of perceivers, without in the process saddling him with any equivocations. The reconciliation relies on the familiar idea that in Leibniz’s idiolect, an aggregate of Fs is that which immediately presupposes those Fs, or in other words, has those Fs as immediate requisites. But I take this idea in a new direction. Taking notice of the fact that Leibniz speaks of three respects in which one thing may immediately presuppose others--i.e., with respect to its being, its existence, and its reality--I argue that a phenomenon having its being in one perceiving substance (monad) can plausibly be understood to presuppose other perceiving substances (monads) in two of these respects. Accordingly, good sense can be made of both the claim that a phenomenon in one monad is an aggregate of other monads (in Leibniz’s technical sense of 'aggregate') and the (equivalent) claim that the latter monads are constituents of the phenomenon (in his technical sense of 'constituent'). So understood, the two conceptions of body are perfectly compatible, just as Leibniz seems to think.

In this paper, the authors describe their initial investigations in computational metaphysics. Our method is to implement axiomatic metaphysics in an automated reasoning system. In this paper, we describe what we have discovered when the theory of abstract objects is implemented in PROVER9 (a first-order automated reasoning system which is the successor to OTTER). After reviewing the second-order, axiomatic theory of abstract objects, we show (1) how to represent a fragment of that theory in PROVER9's first-order syntax, and (2) how PROVER9 then finds proofs of interesting theorems of metaphysics, such as that every possible world is maximal. We conclude the paper by discussing some issues for further research.