Ioannis G. Ntagkas

Features of consciousness difficult to understand in terms of conventional neuroscience have evoked application of quantum theory, which describes the fundamental behavior of matter and energy. In this paper we propose that aspects of quantum theory (e.g. quantum coherence) and of a newly proposed physical phenomenon of quantum wave function "self-collapse"(objective reduction: OR -Penrose, 1994) are essential for consciousness, and occur in cytoskeletal microtubules and other structures within each of the brain's neurons. The particular characteristics of microtubules suitable for quantum effects include their crystal-like lattice structure, hollow inner core, organization of cell function and capacity for information processing. We envisage that conformational states of microtubule subunits (tubulins) are coupled to internal quantum events, and cooperatively interact (compute) with other tubulins. We further assume that macroscopic coherent superposition of quantum-coupled tubulin conformational states occurs throughout significant brain volumes and provides the global binding essential to consciousness. We equate the emergence of the microtubule quantum coherence with pre-conscious processing which grows (for up to 500 milliseconds) until the mass-energy difference among the separated states of tubulins reaches a threshold related to quantum gravity. According to the arguments for OR put forth in Penrose (1994), superpositioned states each have their own space-time geometries. When the degree of coherent mass-energy difference leads to sufficient separation of space-time geometry, the system must choose and decay (reduce, collapse) to a single universe state. In this way, a transient superposition of slightly differing space-time geometries persists until an abrupt quantum classical reduction occurs. Unlike the random, "subjective reduction"( SR, or R) of standard quantum theory caused by observation or environmental entanglement, the OR we propose in microtubules is a self-collapse and it results in particular patterns of microtubule-tubulin conformational states that regulate neuronal activities including synaptic functions.

Gödel appears to have believed strongly that the human mind cannot be explained in terms of any kind of computational physics, but he remained cautious in formulating this belief as a rigorous consequence of his incompleteness theorems. In this chapter, I discuss a modification of standard Gödel-type logical arguments, these appearing to strengthen Gödel’s conclusions, and attempt to provide a persuasive case in support of his standpoint that the actions of the mind must transcend computation. It appears that Gödel did not consider the possibility that the laws of physics might themselves involve noncomputational procedures; accordingly, he found himself driven to the conclusion that mentality must lie beyond the actions of the physical brain. My own arguments, on the other hand, are from the scientific standpoint that the mind is a product of the brain’s physical activity. Accordingly, there must be something in the physical actions of the world that itself transcends computation. We do not appear to find such noncomputational action in the known laws of physics, however, so we must seek it in currently undiscovered laws going beyond presently accepted physical theory. I argue that the only plausibly relevant gap in current understanding lies in a fundamental incompleteness in quantum theory, which reveals itself only with significant mass displacements between quantum states (“Schrödinger’s cats”). I contend that the need for new physics enters when gravitational effects just begin to play a role. In a scheme developed jointly with Stuart Hameroff, this has direct relevance within neuronal microtubules, and I describe this (still speculative) scheme in the following.

Epiphenomenalism is the view that mental events are caused by physical events in the brain, but have no effects upon any physical events. Behavior is caused by muscles that contract upon receiving neural impulses, and neural impulses are generated by input from other neurons or from sense organs. On the epiphenomenalist view, mental events play no causal role in this process. Huxley (1874), who held the view, compared mental events to a steam whistle that contributes nothing to the work of a locomotive. James (1879), who rejected the view, characterized epiphenomenalists' mental events as not affecting the brain activity that produces them "any more than a shadow reacts upon the steps of the traveller whom it accompanies"

This chapter presents a typology of the different kinds of inductive inferences we can draw from our evidence, based on the explanatory relationship between evidence and conclusion. Drawing on the literature on graphical models of explanation, I divide inductive inferences into (a) downwards inferences, which proceed from cause to effect, (b) upwards inferences, which proceed from effect to cause, and (c) sideways inferences, which proceed first from effect to cause and then from that cause to an additional effect. I further distinguish between direct and indirect forms of downwards and upwards inferences. I then show how we can subsume canonical forms of inductive inference mentioned in the literature, such as inference to the best explanation, enumerative induction, and analogical inference, under this typology. Along the way, I explore connections with probability and confirmation, epistemic defeat, the relation between abduction and enumerative induction, the compatibility of IBE and Bayesianism, and theories of epistemic justification.

According to John D. Norton's Material Theory of Induction, all reasonable inductive inferences are justified in virtue of background knowledge about local uniformities in nature. These local uniformities indicate that our samples are likely to be representative of our target population in our inductions. However, a variety of critics have noted that there are many circumstances in which induction seems to be reasonable, yet such background knowledge is apparently absent. I call such absences ‘the frontiers of science', where background scientific theories do not provide information about such local uniformities. I argue that the Material Theory of Induction can be reconciled with our intuitions in favour of these inductions. I adapt an attempted justification of induction in general, the Combinatoric Justification of Induction, into a more modest rationalisation at the less foundational level that the critics discuss. Subject to a number of conditions, we can extrapolate from large samples using our knowledge of facts about the minimum proportions of representative subsets of finite sets. I also discuss some of Norton's own criticisms of his theory and argue that he is overly pessimistic. I conclude that Norton's theory at least performs well at the frontiers of science.

We argue in Roche and Sober (2013) that explanatoriness is evidentially irrelevant in that Pr(H | O&EXPL) = Pr(H | O), where H is a hypothesis, O is an observation, and EXPL is the proposition that if H and O were true, then H would explain O. This is a “screening-off” thesis. Here we clarify that thesis, reply to criticisms advanced by Lange (2017), consider alternative formulations of Inference to the Best Explanation, discuss a strengthened screening-off thesis, and consider how it bears on the claim that unification is evidentially relevant.

How should we reason in science? Jan Sprenger and Stephan Hartmann offer a refreshing take on classical topics in philosophy of science, using a single key concept to explain and to elucidate manifold aspects of scientific reasoning. They present good arguments and good inferences as being characterized by their effect on our rational degrees of belief. Refuting the view that there is no place for subjective attitudes in 'objective science', Sprenger and Hartmann explain the value of convincing evidence in terms of a cycle of variations on the theme of representing rational degrees of belief by means of subjective probabilities (and changing them by Bayesian conditionalization). In doing so, they integrate Bayesian inference—the leading theory of rationality in social science—with the practice of 21st century science. Bayesian Philosophy of Science thereby shows how modeling such attitudes improves our understanding of causes, explanations, confirming evidence, and scientific models in general. It combines a scientifically minded and mathematically sophisticated approach with conceptual analysis and attention to methodological problems of modern science, especially in statistical inference, and is therefore a valuable resource for philosophers and scientific practitioners.

J.L. Mackie insists that ordinary evaluative thought presents itself as a matter of sensitivity to aspects of the world. And this phenomenological thesis seems correct. When one or another variety of philosophical non-cognitivism claims to capture the truth about what the experience of value is like, or (in a familiar surrogate for phenomenology) about what we mean by our evaluative language, the claim is never based on careful attention to the lived character of evaluative thought or discourse. The idea is, rather, that the very concept of the cognitive or factual rules out the possibility of an undiluted representation of how things are, enjoying, nevertheless, the internal relation to 'attitudes' or the will that would be needed to count as evaluative. On this view the phenomenology of value would involve a mere incoherence, if it were as Mackie says--a possibility that then tends (naturally enough) not to be so much as entertained. But, as Mackie sees, there is no satisfactory justification for supposing that the factual is, by definition, attitudinatively and motivationally neutral. This clears away the only obstacle to accepting his phenomenological claim; and the upshot is that non-cognitivism must offer to correct the phenomenology of value, rather than give an account of it. -/- In Machie's view the correction is called for. In this paper I want to suggest that he attributes an unmerited plausibility to this thesis, by giving a false picture of what one is committed to if one resists it.

Unmatched in scholarship and scope, The International Encyclopedia of Ethics is the definitive single-source reference work on Ethics, available both in print and online. Comprises over 700 entries, ranging from 1000 to 10,000 words in length, written by an international cast of subject experts Is arranged across 9 fully cross-referenced volumes including a comprehensive index Provides clear definitions and explanations of all areas of ethics including the topics, movements, arguments, and key figures in Normative Ethics, Metaethics, and Practical Ethics Covers the major philosophical and religious traditions Offers an unprecedented level of authority, accuracy and balance with all entries being blind peer-reviewed.

The possibility that nothing really matters can cause much anxiety, but what would it mean for that to be true? Since it couldn’t be bad that nothing matters, fearing nihilism makes little sense. However, the consequences of belief in nihilism will be far more dramatic than often thought. Many metaethicists assume that even if nothing matters, we should, and would, go on more or less as before. But if nihilism is true in an unqualified way, it can’t be the case that we should go on as before. And given some plausible assumptions about our psychology, it’s also unlikely that we would go on as before: belief in nihilism will lead to loss of evaluative belief, and that will lead to loss or deflation of our corresponding subjective concerns. Now if nothing matters, then this consequence also wouldn’t matter. But this consequence will be extremely harmful if we believe in nihilism but things do matter, an asymmetry that gives us, in Pascalian fashion, pragmatic reasons not to believe in nihilism, and reasons not to try to find out whether it is really true.

This paper aims to cast light on the reasons that explain the shift of opinion—from scepticism to realism—concerning the reality of atoms and molecules in the beginning of the twentieth century, in light of Jean Perrin’s theoretical and experimental work on the Brownian movement. The story told has some rather interesting repercussions for the rationality of accepting the reality of explanatory posits. Section 2 presents the key philosophical debate concerning the role and status of explanatory hypotheses c. 1900, focusing on the work of Duhem, Stallo, Ostwald, Poincaré and Boltzmann. Section 3 examines in detail Perrin’s theoretical account of the molecular origins of Brownian motion, reconstructs the structure and explains the strength of Perrin’s argument for the reality of molecules. Section 4 draws three important lessons for the current debate over scientific realism

In this paper I am concerned with the relation between the history of science and the philosophy of science from the perspective of philosophy. In particular, I examine two philosophical objections against the idea that the history of science can provide evidences to the philosophy of science. The first objection is metaphysical and suggests that given Hume’s law, i.e. that norms cannot be derived from facts and given that the history of science is a descriptive enterprise while the philosophy of science is a normative endeavor, the former cannot be informative for the latter. The second is epistemological and is often called the ‘case studies dilemma’. According to this dilemma, we can neither deduce general philosophical theories from particular historical cases nor test the former through the latter. I argue that although those objections fail to be fatal for the idea that the historical data can provide evidence for the philosophical theories of science, they can help us draw a proper image of the relation between the history and the philosophy of science. I conclude that this picture presupposes the constant epistemic iteration between the two disciplines.

The ongoing steady nature of consciousness in everyday life implies that the underlying neural activity possesses a high level of stability. The prolonged cognitive events of sustained attention, imagery, and working memory also imply high stability of underlying neural activity. This paper proposes that stabilization of neural activity is produced by apical dendrite activity in pyramidal neurons within recurrent corticothalamic circuits, and proposes that the wave activities of apical dendrites that stabilize ongoing activity constitute the subjective impressions of an attended object and the entire sensory background. The cortical minicolumn, as the functional unit of the cortex, is separated into an axis consisting of layer 5 pyramidal neurons and a surrounding shell consisting of layer 2/3 pyramidal neurons. It is proposed that apical dendrites of the axis generate sensory impressions, and basal dendrites of the shell process the brief-lasting input–output identifications of objects that give rise to ideas

Thomas Hofweber has written a very rich book. In line with the conviction that ontology should be informed by linguistic considerations, he develops a systematic approach to central ontological questions as they arise in different regions of discourse. More generally, the book seeks to cast light upon the nature of ontology and its proper place in enquiry. His preferred methodology is not without consequence: it promises, for example, to solve what otherwise look like intractable philosophical puzzles raised by arithmetical practice and numerical discourse, and, likewise, his treatment of propositional discourse has ramifications for larger questions to do with the prospects of metaphysical enquiry generally.

Abstract At the time of The Logical Syntax of Language (Syntax), Quine was, in his own words, a disciple of Carnap’s who read this work page by page as it issued from Ina Carnap’s typewriter. The present paper will show that there were serious problems with how Syntax dealt with ontological claims. These problems were especially pronounced when Carnap attempted to deal with higher order quantification. Carnap, at the time, viewed all talk of reference as being part of the misleading material mode of speech, and as such dismissed, rather than addressed, ontological problems. Central to the analysis in the present paper is the concept of an explication, which was seen by both Carnap and Quine as being of great philosophical importance. It will be shown that the concept of explication played a significant role in how each formulated their mature position on ontology. Both these final positions on ontology can also be seen as a evolving in reaction to Carnap’s flawed handling of ontological matters at the time of Syntax. Carnap, influenced by Tarski’s work on semantics, comes to believe that the concept of reference can be given an acceptable explication, and that by doing so we can see reference to abstract objects as unobjectionable. As a result, Carnap develops a position very different from the one presented in Syntax. Quine strongly rejected the instrumentalism of Syntax, and sought to give an explication of ontological questions that was language independent. This paper closes with a discussion of each’s understanding of the other’s position.

Much of the ontology made in the analytic tradition of philosophy nowadays is founded on some of Quine’s proposals. His naturalism and the binding between existence and quantification are respectively two of his very influential metaphilosophical and methodological theses. Nevertheless, many of his specific claims are quite controversial and contemporaneously have few followers. Some of them are: (a) his rejection of higher-order logic; (b) his resistance in accepting the intensionality of ontological commitments; (c) his rejection of first-order modal logic; and (d) his rejection of the distinction between analytic and synthetic statements. I intend to argue that these controversial negative claims are just interconnected consequences of those much more accepted and apparently less harmful metaphilosophical and methodological theses, and that the glue linking all these consequences to its causes is the notion of extensionality.

Philosophers and theorists have long been puzzled by humans' ability to talk about things that do not exist, or to talk about things that they think exist but, in fact, do not. _Empty Names, Fiction, and the Puzzles of Non-Existence_ is a collection of 13 new works concerning the semantic and metaphysical issues arising from empty names, non-existence, and the nature of fiction. The contributors include some of the most important researchers working in these fields. Some of the papers develop and defend new positions on these matters, while others offer important new perspectives and criticisms of the existing approaches. The volume contains a comprehensive introductory essay by the editors, which provides a survey of the philosophical issues concerning empty names, the various responses to these issues, and the literature on the subject to date

Many significant problems in metaphysics are tied to ontological questions, but ontology and its relation to larger questions in metaphysics give rise to a series of puzzles that suggest that we don't fully understand what ontology is supposed to do, nor what ambitions metaphysics can have for finding out about what the world is like. Thomas Hofweber aims to solve these puzzles about ontology and consequently to make progress on four metaphysical debates tied to ontology: the philosophy of arithmetic, the metaphysics of ordinary objects, the problem of universals, and the question of whether the fact-like aspect of reality is independent of us. Crucial parts of the proposed solution involve considerations about quantification and its relationship to ontology, the place of reference in natural languages, the relationship between syntactic form and focus, whether there could be any ineffable facts, and others.

“Passive fear” denotes a certain type of response to a perceived threat; what is distinctive about the state of passive fear is that its behavioral outlook appears to qualify the emotional experience. I distinguish between two cases of passive fear: one is that of freezing in fear; the other is that of fear-involved tonic immobility. I reconstruct the explanatory strategy that is commonly employed in the field of emotion science, and argue that it leaves certain questions about the nature of passive fear unanswered. I subsequently propose an account of passive fear that builds upon a phenomenological theory of emotions, placing emphasis on the interpretation of current research into human tonic immobility

Talk of the unconscious in the philosophy of emotions concerns twothings. It can refer to an emotion whose existence is not in any way presentto consciousness. Or, it can refer to emotional phenomena whose meaning lies in the unconscious. My interest here is in the former issue of whether emotional states can exceed the reach of conscious awareness. I start with a presentation of psychoanalytic views that inform contemporary work toward a cognitivist analysis of emotion. The discussion of cognitivism leads to a consideration of work in experimental psychology that appears to establish the reality of emotional phenomena that transcend conscious awareness. However, I argue that a careful consideration of the relevant evidence falls short of supporting the claim that there are unconscious emotions