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    A Macrocyclic Chelator That Selectively Binds Ln 4+ over Ln 3+ by a Factor of 10 29
    with T. A. Pham, A. B. Altman, S. C. E. Stieber, C. H. Booth, S. A. Kozimor, W. W. Lukens, Olive D. T., T. Tyliszczak, S. G. Minasian, and Raymond K. N.
    © 2016 American Chemical Society.A tetravalent cerium macrocyclic complex was prepared with an octadentate terephthalamide ligand comprised of hard catecholate donors and characterized in the solution state by spectrophotometric titrations and electrochemistry and in the crystal by X-ray diffraction. The solution-state studies showed that L exhibits a remarkably high affinity toward Ce4+, with log β110 = 61 and ΔG = -348 kJ/mol, compared with log β110 = 32.02 for the analogous Pr3+ complex. In a…Read more
  • © 2016 The Royal Society of Chemistry.The electronic structure in the complete series of stable lanthanide sesquioxides, Ln2O3, has been evaluated using oxygen K-edge X-ray absorption spectroscopy with a scanning transmission X-ray microscope. The experimental results agree with recent synthetic, spectroscopic and theoretical investigations that provided evidence for 5d orbital involvement in lanthanide bonding, while confirming the traditional viewpoint that there is little Ln 4f and O 2p orbit…Read more
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    RNAa is a mechanism by which small dsRNA, termed saRNA, target promoter sequences to induce gene expression. This technique represents a novel approach to gene overexpression without the use of.
  • Coregistration of diffuse optical spectroscopy and magnetic resonance imaging in a rat tumor model
    with S. Merritt, F. Bevilacqua, A. J. Durkin, D. J. Cuccia, R. Lanning, B. J. Tromberg, H. Yu, and O. Nalcioglu
    We report coregistration of near-infrared diffuse optical spectroscopy and magnetic resonance imaging for the study of animal model tumors. A combined broadband steady-state and frequency-domain apparatus was used to determine tissue oxyhemoglobin, deoxyhemoglobin, and water concentration locally in tumors. Simultaneous MRI coregistration provided structural and contrast-enhanced images of the tumor that were correlated with the optical measurements. By use of Monte Carlo simulations, the optica…Read more
  • In vivo quantification of optical contrast agent dynamics in rat tumors by use of diffuse optical spectroscopy with magnetic resonance imaging coregistration
    with D. J. Cuccia, F. Bevilacqua, A. J. Durkin, S. Merritt, B. J. Tromberg, G. Gulsen, H. Yu, and O. Nalcioglu
    We present a study of the dynamics of optical contrast agents indocyanine green and methylene blue in an adenocarcinoma rat tumor model. Measurements are conducted with a combined frequency-domain and steady-state optical technique that facilitates rapid measurement of tissue absorption in the 650–1000-nm spectral region. Tumors were also imaged by use of contrast-enhanced magnetic resonance imaging and coregistered with the location of the optical probe. The absolute concentrations of contrast …Read more
  •  4
    Congruent MRI and near-infrared spectroscopy for functional and structural imaging of tumors
    with G. Gulsen, H. Yu, O. Nalcioglu, S. Merritt, F. Bevilacqua, A. J. Durkin, D. J. Cuccia, R. Lanning, and B. J. Tromberg
    We present a combined near-infrared diffuse optical spectroscopy and Magnetic Resonance Imaging system for the study of animal model tumors. A combined broad-band steady-state and frequency domain optical spectroscopy apparatus was integrated with the MRI. The physiological properties of tissue rendered by MRI, including vascular volume fraction and water, were compared with chromophore concentrations as determined from the parameters obtained by optical measurements. DOS measurements provided o…Read more
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    © 2015 Elsevier B.V.This article demonstrates an instrumented mouthguard capable of non-invasively monitoring salivary uric acid levels. The enzyme -modified screen printed electrode system has been integrated onto a mouthguard platform along with anatomically-miniaturized instrumentation electronics featuring a potentiostat, microcontroller, and a Bluetooth Low Energy transceiver. Unlike RFID-based biosensing systems, which require large proximal power sources, the developed platform enables re…Read more
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    Androgen receptor and chemokine receptors 4 and 7 form a signaling axis to regulate CXCL12-dependent cellular motility
    with J. J. Hsiao, B. H. Ng, M. M. Smits, R. J. Jasavala, H. D. Martinez, J. Lee, J. J. Alston, H. Misonou, J. S. Trimmer, and M. E. Wright
    © Hsiao et al.; licensee BioMed Central.Background: Identifying cellular signaling pathways that become corrupted in the presence of androgens that increase the metastatic potential of organ-confined tumor cells is critical to devising strategies capable of attenuating the metastatic progression of hormone-naïve, organ-confined tumors. In localized prostate cancers, gene fusions that place ETS-family transcription factors under the control of androgens drive gene expression programs that increas…Read more
  • © 2014 American Chemical Society.Attempts to apply artificial nano/micromotors for diverse biomedical applications have inspired a variety of strategies for designing motors with diverse propulsion mechanisms and functions. However, existing artificial motors are made exclusively of synthetic materials, which are subject to serious immune attack and clearance upon entering the bloodstream. Herein we report an elegant approach that turns natural red blood cells into functional micromotors with th…Read more
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    Effect of pay-for-performance incentives on quality of care in small practices with electronic health records: A randomized trial
    with N. S. Bardach, Leon S. F. De, S. C. Shih, W. J. Boscardin, and R. A. le GoldmanDudley
    IMPORTANCE: Most evaluations of pay-for-performance incentives have focused on large-group practices. Thus, the effect of P4P in small practices, where many US residents receive care, is largely unknown. Furthermore, whether electronic health records with chronic disease management capabilities support small-practice response to P4P has not been studied. OBJECTIVE: To assess the effect of P4P incentives on quality in EHR-enabled small practices in the context of an established quality improvemen…Read more
  •  3
    The microstructure of SiO thin films: from nanoclusters to nanocrystals
    with X. F. Wang, Q. Li, A. Hryciw, and A. Meldrum
    Philosophical Magazine 87 (1): 11-27. 2007.