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9Combining integrated systems-biology approaches with intervention-based experimental design provides a higher-resolution path forward for microbiome researchBehavioral and Brain Sciences 42. 2019.The Hooks et al. review of microbiota-gut-brain literature provides a constructive criticism of the general approaches encompassing MGB research. This commentary extends their review by: highlighting capabilities of advanced systems-biology “-omics” techniques for microbiome research and recommending that combining these high-resolution techniques with intervention-based experimental design may be the path forward for future MGB research.