Ran Zhao

The transplanted firm is an important force to promote the network evolution and cluster transformation and upgrading of the undertaking firm. From the micro-analytic perspective of firm network, this paper puts forward a theoretical framework with “relationship-network-evolution” as the main line. Taking the refrigeration industry cluster in Minquan County of China as a case study and keeping the firm networks of economic relation, technical cooperation, and social communication firm network in 2009, 2013, and 2017 as the research objects, this paper analyzes the structure and evolution characteristics of regional firm network system, proposes the degree and effect of the local embeddedness of transplanted firms, and discusses their differences between international and interregional transplanted firms. The results revealed that: the local embeddedness of transplanted firms significantly promotes the development of refrigeration industry network. The network power of large-scale transplanted firms in the cluster is increasing day by day, and the network presents a multi-core trend. The local embeddedness of some transplanted firms is not high, and the overall connectivity of the network is not strong. Network intermediary nodes have strong heterogeneity, and the intermediary role of some large transplanted firms in the network needs to be improved. The three network systems have similar structural characteristics, and social capital plays an important role in the local embeddedness of transplanted firms and the development of regional firm network. Compared with international transplanted firms, interregional transplanted firms are more adaptable in terms of local embeddedness. The research results provide a reference for the construction of similar industrial clusters in China and other developing countries.

The ambiguous development trend of cultural globalization brings both opportunities and challenges to China’s cultural development. English major in colleges and universities, a discipline of cross-cultural education, should look at the cultural communication of the target country dialectically based on the national consciousness of the home country. Since the end of the 20th century, administrators and scholars have paid attention to critical thinking, critical cultural awareness, and critical skills in cross-cultural communication, which are important components of the cross-cultural meaning system. Therefore, all these are collectively referred to as critical cross-cultural literacy. On the basis of the research paradigm of systemic functional linguistics, a language is a semiotic system that creates meaning. Thus, to help students construct and improve their individual CCCL repertoire, teachers need to guide them to critically study and analyze the discourse purpose of the textbook author as well as their language methods and strategies to enrich their meaning potential.

© 2015 by The American Society for Biochemistry and Molecular Biology Inc. Plasminogen activator inhibitor 1 level is extremely elevated in the edematous fluid of acutely injured lungs and pleurae. Elevated PAI-1 specifically inactivates pulmonary urokinase-type and tissue-type plasminogen activators. We hypothesized that plasminogen activation and fibrinolysis may alter epithelial sodium channel activity, a key player in clearing edematous fluid. Two-chain urokinase has been found to strongly stimulate heterologous human αβγ ENaC activity in a dose- and time-dependent manner. This activity of tcuPA was completely ablated by PAI-1. Furthermore, a mutation of the active site of the enzyme also prevented ENaC activation. By comparison, three truncation mutants of the amino-terminal fragment of tcuPA still activated ENaC. uPA enzymatic activity was positively correlated with ENaC current amplitude prior to reaching the maximal level. In sharp contrast to uPA, neither single-chain tPA nor derivatives, including two-chain tPA and tenecteplase, affected ENaC activity. Furthermore, γ but not α subunit of ENaC was proteolytically cleaved at by tcuPA. In summary, the underlying mechanisms of urokinase-mediated activation of ENaC include release of self-inhibition, proteolysis of γ ENaC, incremental increase in opening rate, and activation of closed channels. This study for the first time demonstrates multifaceted mechanisms for uPA-mediated up-regulation of ENaC, which form the cellular and molecular rationale for the beneficial effects of urokinase in mitigating mortal pulmonary edema and pleural effusions.