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2DNA base pairing has been used for many years to direct the arrangement of inorganic nanocrystals into small groupings and arrays with tailored optical and electrical properties. The control of DNA-mediated assembly depends crucially on a better understanding of three-dimensional structure of DNA-nanocrystal-hybridized building blocks. Existing techniques do not allow for structural determination of these flexible and heterogeneous samples. Here we report cryo-electron microscopy and negative-st…Read more
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3Cholesteryl ester transfer protein mediates cholesteryl ester transfer from the atheroprotective high density lipoprotein cholesterol to the atherogenic low density lipoprotein cholesterol. In the past decade, this property has driven the development of CETP inhibitors, which have been evaluated in large scale clinical trials for treating cardiovascular diseases. Despite the pharmacological interest, little is known about the fundamental mechanism of CETP in CE transfer. Recent electron microsco…Read more
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1Commonly used methods for determining protein structure, including X-ray crystallography and single-particle reconstruction, often provide a single and unique three-dimensional structure. However, in these methods, the protein dynamics and flexibility/fluctuation remain mostly unknown. Here, we utilized advances in electron tomography to study the antibody flexibility and fluctuation through structural determination of individual antibody particles rather than averaging multiple antibody particl…Read more
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3Objectives: The aim of the current study was to differentiate between neural activity that represents neural anomalies that are responsible for persistent developmental stuttering from the activity that is a result of compensating for stuttering. This was done by investigating alterations to the intrinsic functional architecture of speech-language processes of patients with PDS before and after a short-term intervention. Methods: The resting-state functional connectivity and cortical thickness w…Read more
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6© 2015 Macmillan Publishers Limited All rights reserved. Genome-wide gene expression measurements have enabled comprehensive studies that integrate the changes of gene expression and phenotypic information to uncover their novel associations. Here we reported the association analysis between psychophysical phenotypes and genome-wide gene expression changes in human adaptation to one of the most extreme climates on Earth, the Antarctic Dome Argus. Dome A is the highest ice feature in Antarctica, …Read more
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2© 2015 Taylor & Francis. This analysis compares the climate impacts over North America during winter associated with various El Niño-Southern Oscillation indices, including the Niño 3.4 index, the leading tropical Pacific outgoing longwave radiation and sea surface temperature covariability, and the eastern Pacific and central Pacific types of ENSO identified from both partial-regression-empirical orthogonal function and regression-EOF approaches. The traditional Niño 3.4 SST index is found to b…Read more
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5Aneuploidy with chromosome instability is a cancer hallmark. We studied chromosome 7 copy number variation in gliomas and in primary cultures derived from them. We found tumor heterogeneity with cells having Chr7-CNV commonly occurs in gliomas, with a higher percentage of cells in high-grade gliomas carrying more than 2 copies of Chr7, as compared to low-grade gliomas. Interestingly, all Chr7-aneuploid cell types in the parental culture of established glioma cell lines reappeared in single-cell-…Read more
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39Superior tolerance of Ag/Ni multilayers against Kr ion irradiation: anin situstudyPhilosophical Magazine 93 (26): 3547-3562. 2013.
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38Fluence-dependent radiation damage in helium ion-irradiated Cu/V multilayersPhilosophical Magazine 93 (8): 883-898. 2013.
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25Theoretical investigation of the optical spectra and local lattice structure for Mn5+in a Sr106F2crystalPhilosophical Magazine 90 (9): 1213-1217. 2010.
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20A structure created by intersectingϵmartensite variant plates in a high-manganese steelPhilosophical Magazine 91 (35): 4410-4426. 2011.
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8Jumping Risk Communities in the Energy Industry: An Empirical Analysis Based on Time-Varying Complex NetworksComplexity 2022 1-12. 2022.This paper uses the 5-five-minute high-frequency data of energy-listed companies in China's A-share market to extract the jump of energy stock prices and build a dynamic stock price jump complex network. Then, we analyze the clustering effect of the complex network. The research shows that the energy stock price jump is an important part of stock price volatility, and the complex network of energy stock jump risk has obvious time-varying characteristics. However, the infection problem of stock p…Read more
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26Investigation of the elemental partitioning behaviour and site preference in ternary model nickel-based superalloys by atom probe tomography and first-principles calculationsPhilosophical Magazine 96 (21): 2204-2218. 2016.
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18Dynamical phenomena in fast sliding nanotube modelsPhilosophical Magazine 93 (8): 922-948. 2013.