Yusuk .

© 2016 American Chemical Society.Hydrostatic pressure applied using diamond anvil cells has been widely explored to modulate physical properties of materials by tuning their lattice degree of freedom. Independently, electrical field is able to tune the electronic degree of freedom of functional materials via, for example, the field-effect transistor configuration. Combining these two orthogonal approaches would allow discovery of new physical properties and phases going beyond the known phase space. Such experiments are, however, technically challenging and have not been demonstrated. Herein, we report a feasible strategy to prepare and measure FETs in a DAC by lithographically patterning the nanodevices onto the diamond culet. Multiple-terminal FETs were fabricated in the DAC using few-layer MoS2 and BN as the channel semiconductor and dielectric layer, respectively. It is found that the mobility, conductance, carrier concentration, and contact conductance of MoS2 can all be significantly enhanced with pressure. We expect that the approach could enable unprecedented ways to explore new phases and properties of materials under coupled mechano-electrostatic modulation.

Proper neurological function in humans requires precise control of levels of the epigenetic regulator methyl CpGbinding protein 2. MeCP2 protein levels are low in fetal brains, where the predominant MECP2 transcripts have an unusually long 39 untranslated region. Here, we show that miR-483-5p, an intragenic microRNA of the imprinted IGF2, regulates MeCP2 levels through a human-specific binding site in the MECP2 long 39 UTR. We demonstrate the inverse correlation of miR-483-5p and MeCP2 levels in developing human brains and fibroblasts from Beckwith-Wiedemann syndrome patients. Importantly, expression of miR-483-5p rescues abnormal dendritic spine phenotype of neurons overexpressing human MeCP2. In addition, miR-483-5p modulates the levels of proteins of the MeCP2-interacting corepressor complexes, including HDAC4 and TBL1X. These data provide insight into the role of miR-483-5p in regulating the levels of MeCP2 and interacting proteins during human fetal development. © 2013 by Cold Spring Harbor Laboratory Press.

ABSTRACT The phenomenological vision, particularly, Husserl’s idea of critique as an infinite vocational theoria and Patočka’s as an enduring programme, view Platonic logic and Socratic act as the paradigms for a normative justification of the idea of universal science and philosophy. In light of that, the Thrasymachus-Socrates debate is interpreted as a case to testify the critical power of philosophy successfully exercised over sophistic tyrannical non-philosophy. This paper criticizes the phenomenological idealization of the Socratic victory as an ethico-teleologically anticipated success of philosophy and rewrites the defeat of Thrasymachus as a political failure in warring with philosophy during which Thrasymachus questions the legitimacy of the act of philosophizing to decide its legitimacy and thereby exposes the politics played out in that act.

The intent of ethics is to establish a set of standards that will provide a framework to modify, regulate, and possibly enhance moral behaviour. Eleven focus groups were conducted with physicians from six culturally distinct countries to explore their perception of formalized, written ethical guidelines (i.e., codes of ethics, credos, value and mission statements) that attempt to direct their ethical practice. Six themes emerged from the data: lack of awareness, no impact, marginal impact, other codes or value statements supersede, personal codes or values dictate, and ethical guidelines are useful. Overall, codes were valued only when they were congruent with existing personal morality. The findings suggest the need to re-evaluate the purpose, content, and delivery of codes for them to improve their function in promoting ethical conduct

Antinomy basically as an inherent structural tension from within the reason between rational willing toward the unconditioned and rational thinking necessarily conditioned by the rule of understanding plays a negative role in and for Kant's system to critically compass reason in limiting itself within the possibility of real experience. In Husserl, under the banner of one all-encompassing reason, antinomy takes a modified form of an ontological incommensurability between two essentially separable regions of being, i.e., between the ideal and the real; such ontological antinomy now takes up the place of an apriori condition for the possibility of meaning for Husserl. Representing a peculiar hierarchical ontological relation through which a lawful power flows, Husserlian antinomy plays an essentially affirmative-political function. In this paper, I will analyze the constructive antinomic structure of phenomenological being relation in contrast to Kantian restrictive antinomy and discuss its political implication.

The concept and the logic of the political, the most notable Schmittian ideas, based on the friend/enemy distinction and his thought on political theology have been widely and critically discussed and actively appropriated with various interpretations. On the other hand, we find that there is certain definite momentum piercing through the theoretical structure of Husserl’s phenomenology in general both as a form of metaphysics and as a philosophical movement, which can also be called the political. In this circumstance, we find the Schmittian logic of the political together with his idea of political theology specifically serviceable for an effective visualization of the political characteristically structured in Husserl’s system, particularly in the concepts of transcendental subjectivity and universal critique. This paper argues that Husserl’s phenomenological critical subject is fundamentally a politico-theological subject and is an attempt to show to what extent and in what way Schmitt can be strategically utilized to make manifest the politicality that we discover as something that structurally inheres in Husserlian notion of subjectivity and critique. *

Traditionally the role and meaning of the knowing subject has been a salient issue for the Western metaphysics, particularly for the modern one. The notion of the measuring subject, corresponding more or less to the knowing subject in the traditional metaphysical sense, whose measuring act directly interferes in the dynamic state of being of an object, takes up a central place in the philosophical narration of quantum mechanics. Nevertheless the possibility for the metaphysical subject and the quantum mechanical subject to have a certain co-relation has not been thought out in both spheres. This paper addresses and discusses precisely that topic: How is the quantum mechanically playing subject to relate to the metaphysical transcendental subject traditionally set out, specifically to the Kantian subject and the Husserlian subject each? Meanwhile it raises a question as to the so-called ‘progressive’ character of quantum mechanics whether the quantum mechanical theory of subject ‘really’ resists the inertia of the Western metaphysical tradition or rather inherits and faithfully upholds it.