•  6
    © 2016, American Society for Biochemistry and Molecular Biology Inc. All rights reserved.Glycyl-tRNA synthetase is the enzyme that covalently links glycine to cognate tRNA for translation. It is of great research interest because of its nonconserved quaternary structures, unique species-specific aminoacylation properties, and noncanonical functions in neurological diseases, but none of these is fully understood. We report two crystal structures of human GlyRS variants, in the free form and in co…Read more
  •  6
    Trend and change-point analyses of water quality time series data have important implications for pollution control and environmental decision-making. This paper developed a new approach to assess trends and change-points of water quality parameters by integrating locally weighted polynomial regression and segmented regression. Firstly, LWPR was used to pretreat the original water quality data into a smoothed time series to represent the long-term trend of water quality. Then, SegReg was used to…Read more
  •  4
    Defining the role of common variation in the genomic and biological architecture of adult human height
    with A. R. Wood, T. Esko, J. Yang, S. Vedantam, T. H. Pers, S. Gustafsson, A. Y. Chu, K. Estrada, J. Luan, Z. Kutalik, N. Amin, M. L. Buchkovich, D. C. Croteau-Chonka, F. R. Day, Y. Duan, T. Fall, R. Fehrmann, T. Ferreira, A. U. Jackson, J. Karjalainen, K. S. Lo, A. E. Locke, R. Mägi, E. Mihailov, E. Porcu, J. C. Randall, A. Scherag, A. A. E. Vinkhuyzen, H. J. Westra, T. W. Winkler, T. Workalemahu, J. H. Zhao, D. Absher, E. Albrecht, D. Anderson, J. Baron, M. Beekman, A. Demirkan, G. B. Ehret, B. Feenstra, M. F. Feitosa, K. Fischer, R. M. Fraser, A. Goel, J. Gong, A. E. Justice, S. Kanoni, M. E. Kleber, K. Kristiansson, U. Lim, V. Lotay, J. C. Lui, M. Mangino, I. M. Leach, C. Medina-Gomez, M. A. Nalls, D. R. Nyholt, C. D. Palmer, D. Pasko, S. Pechlivanis, I. Prokopenko, J. S. Ried, S. Ripke, D. Shungin, A. Stancáková, R. J. Strawbridge, Y. J. Sung, T. Tanaka, A. Teumer, S. Trompet, S. W. Van Der Laan, J. Van Setten, J. V. Van Vliet-Ostaptchouk, L. Yengo, W. Zhang, U. Afzal, J. Ärnlöv, G. M. Arscott, S. Bandinelli, A. Barrett, C. Bellis, A. J. Bennett, C. Berne, and B.
    © 2014 Nature America, Inc. All rights reserved. Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated 1/42,000, 1/43,700 and 1/49,500 SNPs explained 1/421%, 1/424% and 1/429% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability.…Read more
  •  3
    Plasmon-generated hot carriers are used in photovoltaic or photochemical applications. However, the interplays between the plasmon and single-particle excitations in nanosystems have not been theoretically addressed using ab initio methods. Here we show such interplays in a Ag 55 nanocluster using real-time time-dependent density functional theory simulations. We find that the disappearance of the zero-frequency peak in the Fourier transform of the band-to-band transition coefficient is a hallma…Read more
  •  2
    Gene inactivation by multiphoton-targeted photochemistry
    with M. W. Berns, A. Dunn, V. Wallace, and V. Venugopalan
    Multiphoton-targeted photochemistry was used to selectively inactivate the expression of genes in vertebrate cells. A membrane permeable DNA-associating vital dye, ethidium bromide monoacetate was used to photosensitize chromosomes in dividing cells. A 100-ps infrared laser beam operating at 1.06 microns was focused onto a selected region of a mitotic chromosome corresponding to the sites of the nucleolar genes. Individual cells followed through mitosis demonstrated a reduction in the number of …Read more
  •  1
    Accurate model annotation of a near-atomic resolution cryo-EM map
    with C. F. Hryc, D. H. Chen, P. V. Afonine, J. Jakan, C. Haase-Pettingell, W. Jiang, P. D. Adams, J. A. King, M. F. Schmid, and W. Chiu
    Electron cryomicroscopy has been used to determine the atomic coordinates from density maps of biological assemblies. These models can be assessed by their overall fit to the experimental data and stereochemical information. However, these models do not annotate the actual density values of the atoms nor their positional uncertainty. Here, we introduce a computational procedure to derive an atomic model from a cryo- EM map with annotated metadata. The accuracy of such a model is validated by a f…Read more