Alfred Gierer

Max-Planck-Institute of Developmental Biology, Tuebingen, Germany
  •  342
    Abstract in English: The short essay is about impressive philosophical ideas of the great German dramatist Friedrich Schiller (1749-1805). In his “letters on the aesthetic education…” he critisizes, with respect to human behaviour, too much reason and too stringent principles, leading to a neglect of positive emotions such as empathy; he argues in favour of an aesthetic lifestyle. This is supported by biological as well as mental aspects of human self-understanding. My article follows these line…Read more
  •  918
    This book (in German) on "Physics, life and mind" is on the physical foundations of modern biology. The basic features of living systems, reproduction, mutation and metabolism, can be explained in terms of molecular processes involving nucleic acids as genetic material, and proteins as catalysts. The generation of structure and form in each generation results from spatiotemporal gene regulation in conjunction with the de novo formation of spatial order in which interplays of activation and inhib…Read more
  •  160
    Was ist der Mensch?
    In D. Ganten, V. Gerhardt, J. Nida-Rümelin & J. C. Heilinger (eds.), Was ist der Mensch? Humanprojekt der BBAW, De Gruyter. pp. 103-105. 2008.
    Der Text ist eines von achtzig Kurzessays zum Thema „Was ist der Mensch“, zu denen unsere Arbeitsgruppe „Humanprojekt“ der Berlin-Brandenburgischen Akademie der Wissenschaften eingeladen hat. So genau Aussagen inhaltlicher Naturwissenschaft oft sind, auf der metatheoretischen Ebene bleibt die Gesamtheit unseres Wissens, und damit auch die Stellung des Menschen in der Natur deutungsfähig und deutungsbedürftig; sie ist mit verschiedenen, natürlich nicht mit allen, philosophischen, kulturellen und…Read more
  •  292
    Regeneration of Hydra from aggregated cells
    with S. Berking, H. Bode, C. N. David, K. Flick, G. Hansmann, H. Schaller, and E. Trenkner
    Nature New Biology 239 98-101. 1972.
    • Aggregates of previously isolated cells of Hydra are capable, under suitable solvant conditions, of regeneration forming complete animals. In a first stage, ecto- and endodermal cells sort out, producing the bilayered hollow structure characteristic of Hydra tissue; thereafter, heads are formed (even if the original cell preparation contained no head cells), eventually leading to the separation of normal animals with head, body column and foot. Hydra appears to be the highest type of organism …Read more
  •  411
    Biological evolution and technological innovation, while differing in many respects, also share common features. In particular, implementation of a new technology in the market is analogous to the spreading of a new genetic trait in a population. Technological innovation may occur either through the accumulation of quantitative changes, as in the development of the ocean clipper, or it may be initiated by a new combination of features or subsystems, as in the case of steamships. Other examples o…Read more
  •  419
    Validity of physical laws for any aspect of brain activity and strict correlation of mental to physical states of the brain do not imply, with logical necessity, that a complete algorithmic theory of the mind-body relation is possible. A limit of decodability may be imposed by the finite number of possible analytical operations which is rooted in the finiteness of the world. It is considered as a fundamental intrinsic limitation of the scientific approach comparable to quantum indeterminacy and …Read more
  •  627
    The essay is an English version of the German article "Wissenschaftliche Rationalität, menschliches Bewusstsein und pro-religiöse Ideen". It discusses immanent versus transcendent concepts in the context of the art of living, as well as the understanding of human consciousness in the context of religion. Science provides us with a far reaching understanding of natural processes, including biological evolution, but also with deep insights into its own intrinsic limitations. This is consistent wi…Read more
  •  220
    The development of modern science has depended strongly on specific features of the cultures involved; however, its results are widely and trans-culturally accepted and applied. The science and technology of electricity provides a particularly interesting example. It emerged as a specific product of post-Renaissance Europe, rooted in the Greek philosophical tradition that encourages explanations of nature in theoretical terms. It did not evolve in China presumably because such encouragement was …Read more
  •  551
    Eriugena and alKindi, 9th Century Protagonists of pro-Scientific Cultural Change
    Abridged English translation of: Acta Historica Leopoldina 29. 1999.
    Ancient Greek philosophers were the first to postulate the possibility of explaining nature in theoretical terms and to initiate attempts at this. With the rise of monotheistic religions of revelation claiming supremacy over human reason and envisaging a new world to come, studies of the natural order of the transient world were widely considered undesirable. Later, in the Middle Ages, the desire for human understanding of nature in terms of reason was revived. This article is concerned with the…Read more
  • Hydra as a Model for the Development of Biological Form
    Scientific American 231 (6): 44-54. 1974.
    Cells isolated from this freshwater polyp can aggregate and form a complete new animal. Experiments with the system lend support to a physico-chemical scheme for the creation of biological pattern.
  •  339
    The full text of this essay is available in an English translation (also in philpapers) under: Alfred Gierer, Science, religion, and basic biological issues that are open to interpretation. Der Artikel bildet das Schlusskapitel des Buches " Alfred Gierer: Wissenschaftliches Denken, das Rätsel Bewusstsein und pro-religiöse Ideen", Königshausen&Neumann, Würzburg 2019. Reichweite und Grenzen naturwissenschaftlicher Erklärungen ergeben sich zum einen aus der universellen Gültigkeit phys…Read more
  •  392
    Within the sedimentation diagram of infective RNA preparations isolated from Tobacco Mosaic Virus, undegraded molecules form a sharp peak with a molecular weight corresponding to the total RNA content of the virus particle. Degradation kinetics by ribonuclease is of the linear, single-target type, indicating that the RNA is single-stranded. The intact RNA of a virus particle thus forms one big single-stranded molecule. Quantitative evaluation of the effect degradation by RNA-ase on the infectivi…Read more
  •  560
    Infectivity of ribonucleic acid from Tobacco Mosaic Virus
    with Gerhard Schramm
    Nature 177 702-703. 1956.
    Upon separation of the protein from the nucleic acid component of tobacco mosaic virus by phenol, using a fast and gentle procedure, the nucleic acid is infective in assays on tobacco leaves. A series of qualitative and quantitative control experiments demonstrates that the biological activity cannot depend on residual proteins in the preparation, but is a property of isolated nucleic acid which is thus the genetic material of the virus.
  •  2293
    A theory of biological pattern formation
    with Hans Meinhardt
    Kybernetik, Continued as Biological Cybernetics 12 (1). 1972.
    The paper addresses the formation of striking patterns within originally near-homogenous tissue, the process prototypical for embryology, and represented in particularly purist form by cut sections of hydra regenerating, by internal reorganisation of the pre-existing tissue, a complete animal with head and foot. The essential requirements are autocatalytic, self-enhancing activation, combined with inhibitory or depletion effects of wider range – “lateral inhibition”. Not only de-novo-pattern for…Read more
  •  509
    The Hydra model - a model for what?
    International Journal of Developmental Biology 56 437-445. 2012.
    The introductory personal remarks refer to my motivations for choosing research projects, and for moving from physics to molecular biology and then to development, with Hydra as a model system. Historically, Trembley’s discovery of Hydra regeneration in 1744 was the begin¬ning of developmental biology as we understand it, with passionate debates about preformation versus de novo generation, mechanisms versus organisms. In fact, seemingly conflicting bottom-up and top-down concepts are both requi…Read more
  •  1
    Physics, Life and Mind: The scope and limitations of science
    In Iain Paul Jan Fennema (ed.), Second European Conference on Science and Religion, Kluwer Academic Publishers. pp. 61-71. 1988.
    What, precisely, are the ‘changing perspectives on reality’ in contemporary scientific thought? The topics of the lecture are the scope and the limits of science with emphasis on the physical foundations of biology. The laws of physics in general and the physics of molecules in particular form the basis for explaining the mechanism of reproduction, the generation of structure and form in the course of the development of the individual organism, the evolution of the diversity and complexity of or…Read more
  •  472
    Applying mild methods of preparation, part of the ribosomes of rabbit reticulocytes are found in aggregates (later called polyribosomes) of up to six ribosomal units. Upon treatment with RNA-ase, they desintegrate into single ribosomes. The fast-sedimenting aggregates are found to be more active in protein synthesis in terms of incorporation of radioactive amino acids, whereas the single ribosomes are more receptive to stimulation by the artificial messenger RNA poly-U. The findings indicate tha…Read more
  • Georg Ernst Stahl (1659-1734) in wissenschaftshistorischer Sicht (edited book)
    with Dietrich von Engelhardt
    Acta Historica Leopoldina 30. 2000.
    Georg Ernst Stahl (1659-1734) was a German physician and chemist. The book (in German) documents a symposium of the Academy Leopoldina on his works and thoughts that contributed to the Enlightenment. Der weite Horizont seines Denkens und seiner Arbeiten umfasst die Phlogiston-Theorie der Verbrennung, die später mit der Entdeckung des Sauerstoffs widerlegt wurde, aber dennoch wichtige Erkenntnisse zur Reversibilität von Reaktionen und zur unsichtbaren Persistenz der beteiligten chemischen Kompo…Read more