X. Wang

A series of derivatives of the known thromboxane A2 prostanoid receptor antagonists, 3-sulfonamido)-5,6,7,8-tetrahydronaphthalen-1-yl)propanoic acid and 3-sulfonamido)ethyl)phenyl) propanoic acid, were synthesized in which the carboxylic acid functional group was replaced with substituted cyclopentane-1,3-dione bioisosteres. Characterization of these molecules led to the discovery of remarkably potent new analogues, some of which were considerably more active than the corresponding parent carboxylic acid compounds. Depending on the choice of the C2 substituent of the CPD unit, these new derivatives can produce either a reversible or an apparent irreversible inhibition of the human TP receptor. Given the potency and the long-lasting inhibition of TP receptor signaling, these novel antagonists may comprise promising leads for the development of antithromboxane therapies.

© 2016 Optical Society of America.We propose an all-solid-state tunable Bragg filter with a phase transition material as the defect layer. Bragg filters based on a vanadium dioxide defect layer sandwiched between silicon dioxide/titanium dioxide Bragg gratings are experimentally demonstrated. Temperature dependent reflection spectroscopy shows the dynamic tunability and hysteresis properties of the Bragg filter. Temperature dependent Raman spectroscopy reveals the connection between the tunability and the phase transition of the vanadium dioxide defect layer. This work paves a new avenue in tunable Bragg filter designs and promises more applications by combining phase transition materials and optical cavities.

© 2015 American Association for Cancer Research.Purpose: Myxopapillary ependymoma is a distinct histologic variant of ependymoma arising commonly in the spinal cord. Despite an overall favorable prognosis, distant metastases, subarachnoid dissemination, and late recurrences have been reported. Currently, the only effective treatment for MPE is gross-total resection. We characterized the genomic and transcriptional landscape of spinal ependymomas in an effort to delineate the genetic basis of this disease and identify new leads for therapy. Experimental Design: Gene expression profiling was performed on 35 spinal ependymomas, and copy number profiling was done on an overlapping cohort of 46 spinal ependymomas. Functional validation experiments were performed on tumor lysates consisting of assays measuring pyruvate kinase M activity, hexokinase activity, and lactate production. Results: At a gene expression level, we demonstrate that spinal grade II and MPE are molecularly and biologically distinct. These are supported by specific copy number alterations occurring in each histologic variant. Pathway analysis revealed that MPE are characterized by increased cellular metabolism, associated with upregulation of HIF1α. These findings were validated by Western blot analysis demonstrating increased protein expression of HIF1α, HK2, PDK1, and phosphorylation of PDHE1A. Functional assays were performed on MPE lysates, which demonstrated decreased PKM activity, increased HK activity, and elevated lactate production. Conclusions: Our findings suggest that MPE may be driven by a Warburg metabolic phenotype. The key enzymes promoting the Warburg phenotype: HK2, PKM2, and PDK are target-able by small-molecule inhibitors/activators, and should be considered for evaluation in future clinical trials for MPE.

The restaurant trade secrets protection system for the study of the construction of the center of gravity, analysis of a number of ways to protect trade secrets, its ultimate purpose is to establish a catering business technology-oriented development concept, to promote the catering enterprises bigger and stronger, therefore, to establish suitable for their own characteristics of a comprehensive trade secrets protection system should be the best choice for catering enterprises. On the basis of studying the protection system of bussiness confidentiality in the area of ​​diet, the paper tries to analyze several protection methods. The purpose is to encourage the view that technology is the most important and improve the enterprise's power in this area. It's reasonable for the enterprise of diet to set up the suitable and comprehensive protection system which just suits to its own characters

Since the publication of Matteo Ricci's Tianzhu shiyi, sheng 聖 was commonly accepted as the translation of Catholic saints in China. A closer study, however, suggests that the use of sheng as the translation of saints was not an unquestioned process. In fact, the use of sheng diverged soon after the death of Matteo Ricci and disagreements continued at least into the early eighteenth century in the Catholic circle in China. This article seeks to deepen the understanding about the use of sheng as translation of saints in the seventeenth- and eighteenth-century China. I focus on the examples of Alfonso Vagnone, Zhang Xingyao and Yan Mo, who represented three different approaches to sheng as the translation of saints in relation to sheng in reference to sages in the Confucian tradition. As we know, the Catholic Church eventually took the solution suggested by Yan Mo, who advocated referring to both Catholic saints and Confucian sages as sheng while maintaining a clear distinction between the two groups. But, before the decision was made in the twentieth century, there was much tension and complexity to translating the concept of Catholic saints as sheng.

This study explored the association between out-of-school physical activity and mathematical achievement in relation to mathematical anxiety, as well as the influence of parents’ support for their children’s physical activity on this association, to examine whether parental support for physical activity affects mental health and academic performance. Data were collected from the responses of 22,509 children in Grade 4 from six provinces across eastern, central, and western China who completed the mathematics component and the physical education and health component of the national-level education quality assessment. A moderated moderated-mediation model was tested using PROCESS v3.4 and SPSS v19.0, with socioeconomic status, school location, and body mass index as controlled variables. Out-of-school physical activity had a positive effect on children’s mathematical achievement, and math anxiety partially mediated this association. The indices of conditional moderated mediation through the parental support of both girls and boys were, respectively, significant, indicating that children can benefit from physical activity, and that increased perceived parental support for physical activity can alleviate their children’s math anxiety and improve their mathematics, regardless of gender. However, gender differences were observed in the influence of parental support for physical activity on anxiety: Although girls’ math anxiety levels were significantly higher, the anxiety levels of girls with high parental support were significantly lower than those of boys with low parental support.

In the presence of heterogeneity between the randomized controlled trial (RCT) participants and the target population, evaluating the treatment effect solely based on the RCT often leads to biased quantification of the real-world treatment effect. To address the problem of lack of generalizability for the treatment effect estimated by the RCT sample, we leverage observational studies with large samples that are representative of the target population. This article concerns evaluating treatment effects on survival outcomes for a target population and considers a broad class of estimands that are functionals of treatment-specific survival functions, including differences in survival probability and restricted mean survival times. Motivated by two intuitive but distinct approaches, i.e., imputation based on survival outcome regression and weighting based on inverse probability of sampling, censoring, and treatment assignment, we propose a semiparametric estimator through the guidance of the efficient influence function. The proposed estimator is doubly robust in the sense that it is consistent for the target population estimands if either the survival model or the weighting model is correctly specified and is locally efficient when both are correct. In addition, as an alternative to parametric estimation, we employ the nonparametric method of sieves for flexible and robust estimation of the nuisance functions and show that the resulting estimator retains the root- n n consistency and efficiency, the so-called rate-double robustness. Simulation studies confirm the theoretical properties of the proposed estimator and show that it outperforms competitors. We apply the proposed method to estimate the effect of adjuvant chemotherapy on survival in patients with early-stage resected non-small cell lung cancer.

Resumo: O pós-modernismo ocidental é uma tendência cultural de pensamento que surgiu nas décadas de 1960 e 1970. Sua influência envolve muitos campos, como arte, literatura, filosofia e estética, o que indica que uma grande mudança ocorreu em toda a sociedade ocidental e também tem um impacto profundo na cultura e na arte contemporâneas. Ao analisar a influência de longo alcance do pós-modernismo, na música e na filosofia, este artigo fornece estratégias de desenvolvimento e sugestões para a música e a filosofia, sob o pano de fundo do pós-modernismo. Este texto estudou os efeitos positivos e negativos do pós-modernismo na filosofia e na música, sob dois aspectos: música e filosofia. A influência positiva do pós-modernismo na filosofia e na música manifesta-se na defesa da igualdade, da harmonia entre o homem e a natureza, da inovação e do espírito crítico. É claro que a tendência de pensamento do pós-modernismo também tem alguns efeitos negativos, os quais devem ser vistos dialeticamente, em seu impacto sobre a música e a filosofia. Com a premissa de incentivar a inovação, respeitar a liberdade e a diferença, deve-se estabelecer uma autoconfiança de valor, de modo a promover o desenvolvimento da filosofia e da música. O pós-modernismo é uma forma cultural do período posterior do capitalismo. No campo da música, é necessário não apenas aderir à rebeldia e à abertura trazidas pelo pós-modernismo, mas também dar importância ao valor artístico das obras musicais para evitar a produção e a proliferação de obras musicais vulgarizadas. A influência do pós-modernismo na música e na filosofia, que estudamos neste artigo, tem um significado prático importante.