Angela Lee

© 2015 Elsevier Ireland Ltd.The fornix is the primary subcortical output fiber system of the hippocampal formation. In children with 22q11.2 deletion syndrome, hippocampal volume reduction has been commonly reported, but few studies as yet have evaluated the integrity of the fornix. Therefore, we investigated the fornix of 45 school-aged children with 22q11.2DS and 38 matched typically developing children. Probabilistic diffusion tensor imaging tractography was used to reconstruct the body of the fornix in each child[U+05F3]s brain native space. Compared with children, significantly lower fractional anisotropy and higher radial diffusivity was observed bilaterally in the body of the fornix in children with 22q11.2DS. Irregularities were especially prominent in the posterior aspect of the fornix where it emerges from the hippocampus. Smaller volumes of the hippocampal formations were also found in the 22q11.2DS group. The reduced hippocampal volumes were correlated with lower fornix FA and higher fornix RD in the right hemisphere. Our findings provide neuroanatomical evidence of disrupted hippocampal connectivity in children with 22q11.2DS, which may help to further understand the biological basis of spatial impairments, affective regulation, and other factors related to the ultra-high risk for schizophrenia in this population.

Taiwan has gradually transformed from an authoritarian to a democratic society. The education system is moving from uniformity to diversity, from authoritarian centralization to deregulation and pluralism. Moral education is a reflection of, and influenced by, educational reform and social change, as this paper shows in describing the history of moral education in Taiwan. From 1949 to the 1980s, Taiwan's moral education consisted of ideological, nationalistic, political education and the teaching of a strict code of conduct. Since the late 1980s moral education has changed rapidly due to educational reforms. Political ideologies and traditional culture in moral education have gradually been phased out. Since August 2004, diversified and generalized moral education has replaced the special subject of moral education offered in school. Moral education in Taiwan faces great changes and new challenges. The paper concludes by suggesting some strategies, such as facilitating critical thinking, civic values and multiple teaching approaches, for the development of a new moral education suitable to modern democratic society in Taiwan.