Anirudh Nair

We present the case of a patient with a vestibular schwannoma (VS) who developed vascular complications following surgery and discuss the potential mechanisms. Additionally, we systematically searched the literature to identify citations on vascular and brain stem complications following VS surgery. We excluded the articles related to facial and vestibulocochlear nerve–related complications and other complications, such as headache, tinnitus, and ataxia. We also excluded the articles related to recurrent vestibular schwannoma because our article focuses on primary VS surgery–related complications due to vascular injury. We have clearly come a long way in managing vestibular schwannoma (VS) surgery over the past century. In the early twentieth century, VS surgery entailed high morbidity and mortality. The principles of microneurosurgery have improved the outcomes of surgery on VSs to a great extent. The current concept in modern VS surgery is maximal safe resection with minimal complications and minimal cranial nerve deficits. The management of VS has undergone a paradigm shift from reducing mortality to facial nerve preservation and the preservation of hearing. Surgery of the cerebellopontine (CP) angle requires a unique skill set and is a craft in that any iatrogenic damage can have devastating results on the neurovascular structures and brain stem in the vicinity. As with other neurosurgical procedures, the goal of VS surgery is to minimize complications, but complications are always possible, from the positioning of the patient under general anaesthesia to complications during the various steps of VS surgery. In spite of advancements in surgical techniques and better illumination provided by modern high-end microscopes, the surgical removal of large and giant vestibular schwannomas with good preservation of facial nerve function continues to be one of the most challenging operations in modern neurosurgery. The complexity of operating on the vestibular schwannoma is attributable not only to the difficult anatomy in the CP angle but also to the presence of multiple vital neurovascular structures and the brain stem in the vicinity. The various complications arising out of surgery for vestibular schwannomas range from one or more cranial nerve deficits to life-endangering complications associated with vascular and/or brain stem damage. The senior author, who has a personal experience with consecutively operating on 835 such cases of large and giant vestibular schwannoma, describes the clinical course following petrosal vein damage to a patient who underwent a standard retrosigmoid operation for a large vestibular schwannoma. We retrospectively analyse the critical management issues that could have reduced the unexpected morbidity resulting in a prolonged hospital stay.

Behavioural variant frontotemporal dementia (bvFTD) is a subtype of frontotemporal dementia characterized by changes in personality, social behaviour, and cognition. Although neural abnormalities cause bvFTD patients to struggle with inhibiting problematic behaviour, they are generally considered fully autonomous individuals. Subsequently, bvFTD patients demonstrate understanding of right and wrong but are unable to act in accordance with moral norms. To investigate the ethical, legal, and social issues associated with bvFTD, we conducted a scoping review of academic literature with inclusion & exclusion criteria and codes derived from our prior work. Among our final sample of fifty-six articles, four mentioned bvFTD patient-offenders as unfit to stand trial by insanity, and sixteen mentioned the use of dementia evidence in a court of law to better understand the autonomy of bvFTD patients. Additional emergent issues that were discovered include: training police officers to handle situations involving bvFTD patients and educating healthcare providers on how to help caregivers navigate bvFTD. The current literature highlights the inadequacy of traditional applications of medico-legal categories such as autonomy, capacity and competence, in informing cognitive capacity assessments in clinical and legal settings and deserves consideration by neuroethicists.

Before Euro-American settlement, many Native American nations intercropped maize (_Zea mays_), beans (_Phaseolus vulgaris_), and squash (_Cucurbita pepo_) in what is colloquially called the “Three Sisters.” Here we review the historic importance and consequences of rejuvenation of Three Sisters intercropping (3SI), outline a framework to engage Native growers in community science with positive feedbacks to university research, and present preliminary findings from ethnography and a randomized, replicated 3SI experiment. We developed mutually beneficial collaborative research agendas with four Midwestern US Native American nations. Ethnographic data highlighted a culturally based respect for 3SI as living beings, the importance it holds for all cultural facets of these Native nations, and the critical impact the practice has on environmental sustainability. One concern expressed by Native growers during ethnographic research was improving soil health—part of the rationale for establishing the 3SI agronomic experiment. To address this, we collaboratively designed a 3SI experiment. After 1 year, 3SI increased short-term soil respiration by 24%, decreased salt-extractable nitrate by 54%, had no effect on soil microbial biomass (but increased its carbon-to-nitrogen ratio by 32%) compared to the average of monoculture crops. The overarching purpose of this collaborative project is to develop a deeper understanding of 3SI, its cultural importance to Native communities, and how reinvigorating the practice—and intercropping in general—can make agroecosystems more sustainable for people and the environment.