Emiliano Loria

The resurgence of interest in psychedelic substances for psychiatric treatment has sparked both excitement and scepticism within the scientific community. This paper addresses the moralisation and hype surrounding psychedelic therapies. Through a systematic review of the literature and a detailed case study, we illustrate that the therapeutic effect of psychedelics is not solely pharmacological but is instead facilitated by their ability to enhance psychotherapy. The paper explores the historical context of psychedelics in psychiatry, their mechanism of action, and evidence of their efficacy in treating depression. We highlight the necessity of integrating psychedelics with psychotherapeutic interventions and emphasise the importance of methodological rigour and ethical standards in psychedelic research and practice. By presenting an informed understanding of psychedelic treatments, we advocate for their consideration as legitimate alternatives alongside traditional therapies, offering a potential paradigm shift in psychiatric care.

Long-standing psychiatric practice confirms the pervasive use of pharmacological therapies for treating severe mental disorders. In many circumstances, drugs constitute the best allies of psychotherapeutic interventions. A robust scientific literature is oriented on finding the best strategies to improve therapeutic efficacy through different modes and timing of combined interventions. Nevertheless, we are far from triumphal therapeutic success. Despite the advances made by neuropsychiatry, this medical discipline remains lacking in terms of diagnostic and prognostic capabilities when compared to other branches of medicine. An ethical principle remains as the guidance of therapeutic interventions: improving the quality of life for patients. Unfortunately, psychotropic drugs and psychotherapies do not always result in an efficient remission of symptoms. In this paper I corroborate the idea that therapists should provide drug-resistant patients with every effective and available treatment, even if some of such interventions could be invasive, like Electroconvulsive Therapy (ECT). ECT carries upon its shoulders a long and dramatic history that should be better investigated to provide new insights. In fact, ECT has attracted renewed interest in recent years. This is due to the fact that antidepressant drugs in younger patients show often scarce effectiveness and unpleasant side-effects. Moreover, I show that, thanks to modern advances, ECT may work as a successful form of treatment for specific and rare cases, such as severe depression (with suicide attempts) and catatonia.

The Australian philosopher Philip Gerrans ambitiously tries to provide a general theory about the formation of delusions that should enclose neuronal, cognitive and phenomenological levels of description. His theory is defined as narrative and it is grounded on the so called “default thoughts”, that consist in simulations, autobiographical narrative fragments produced by the Default Mode Network (DMN). The DMN is a powerful simulation system that evolved to allow humans to simulate and imagine experiences in the absence of an eliciting stimulus. Such imaginative/simulative process is precariously disciplined by the Self’s demands of narrative coherence. The Author’s aim is to waive the notion of belief and the causal role played by the impairments of fixation-beliefs system in the onset of delusions, as predicted by the principle doxastic theories.

In the last decades neuroscience provided so many important contributions to philosophy of mind that nowadays the latter is inconceivable without the former in every topic this philosophical branch deals with. The studies connected to action understanding provided great advances in the field of developmental psychology for what concerns social learning abilities grounded on imitation. All information received by the infants are transmitted through actions. It would be impossible to conceive infant imitation without action interpretation. According to Meltzoff’s “like-me” hypothesis, imitation is possible in human infants already at birth in virtue of an identification mechanism with the adults supported by mirror neurons (MNs) based simulation system. However, if we split the types of actions into two general categories, instrumental and communicative actions, we will see, according to an alternative account, how infants modulate differently the comprehension of observed scenarios, depending on whether they are passive observers (in the case of instrumental actions) or actively involved (in the case of communicative actions). Such a recognition of action features seems to be evident through different degrees of motor activation, as ERP techniques applied to infants and young adults revealed. Neuroscientific evidence highlight the crucial role of brain areas connected to motor activation for action interpretation, but at the same time, they allow both a bottom-up process and a top-down process interpretation whereby the motor activation is seen as a product of action understanding rather than its determining causal factor. The aim of the present study is to examine such epistemological conflicting perspectives underlying action interpretation, and their repercussions on different social learning theories.

Natural Pedagogy refers to social learning based on ostensive communication between adults and infants which results in rapid and efficient transmission of cultural information. The theory predicts that children are able to recognize communicative intention when adults address them using ostensive signals. Furthermore, natural pedagogy predicts that infants ascribe the knowledge they have acquired to others according to what is called the “assumption of universality”. In other words, infants are able to ascribe informative contents to others even when they are outside the bounds of the learning context. Although Csibra and Gergely have so far denied any type of relationship between natural pedagogy and mindreading capacities, I suggest that early mindreading capacities are components of the natural pedagogy system, as recent experimental findings on early Theory of Mind abilities appear to show.