Houston, Texas, United States of America
  •  7
    Molecular architecture of contactin-Associated protein-like 2 and its interaction with contactin 2
    with Z. Lu, Mvvvs Reddy, J. Liu, A. Kalichava, L. Zhang, Y. Wang, L. M. F. Holthauzen, M. A. White, S. Seshadrinathan, X. Zhong, G. Ren, and G. Rudenko
    Contactin-Associated protein-like 2 is a large multidomain neuronal adhesion molecule implicated in a number of neurological disorders, including epilepsy, schizophrenia, autism spectrum disorder, intellectual disability, and language delay. We reveal here by electron microscopy that the architecture of CNTNAP2 is composed of a large, medium, and small lobe that flex with respect to each other. Using epitope labeling and fragments, we assign the F58C, L1, and L2 domains to the large lobe, the FB…Read more
  •  3
    Mutual antagonism between Sox10 and NFIA regulates diversification of glial lineages and glioma subtypes
    with S. M. Glasgow, W. Zhu, C. C. Stolt, T. W. Huang, J. J. LoTurco, J. L. Neul, M. Wegner, C. Mohila, and B. Deneen
    Lineage progression and diversification is regulated by the coordinated action of unique sets of transcription factors. Oligodendrocytes and astrocytes comprise the glial sub-lineages in the CNS, and the manner in which their associated regulatory factors orchestrate lineage diversification during development and disease remains an open question. Sox10 and NFIA are key transcriptional regulators of gliogenesis associated with OL and AS. We found that NFIA inhibited Sox10 induction of OL differen…Read more