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    Regulation of sex determination in mice by a non-coding genomic region
    with V. A. Arboleda, A. Fleming, E. Délot, J. S. Sinsheimer, and E. Vilain
    To identify novel genomic regions that regulate sex determination, we utilized the powerful C57BL/6J-YPOS model of XY sex reversal where mice with autosomes from the B6 strain and a Y chromosome from a wild-derived strain, Mus domesticus poschiavinus, show complete sex reversal. In B6-YPOS, the presence of a 55-Mb congenic region on chromosome 11 protects from sex reversal in a dose-dependent manner. Using mouse genetic backcross designs and high-density SNP arrays, we narrowed the congenic regi…Read more