Haoran Zhang

This article explores ecological theology in mainland China from 1990 to 2024 through the lens of Stephen B. Bevans’ contextual theology. By analysing its reception, it becomes clear that a distinctly contextualised ecological theology has not yet emerged in China. Considering this gap, the article examines potential directions for Chinese ecological theology across four dimensions of contextual theology. The academic and religious communities should focus on diversified yet overlapping approaches to develop Chinese ecological theology collaboratively. From the perspective of mutual learning between Chinese and Western civilisations, Chinese ecological theology should adopt ‘synthetic model’ to integrate traditional Chinese concepts of ‘Heaven-Nature-Human’ and respond to both local and global challenges. A synthetic model of Chinese ecological theology could become a significant voice in the international theological community, contributing to global sustainable prosperity.Contribution: This article makes two contributions. Firstly, it provides a systematic review and reflection on ecological theology in mainland China from 1990 to 2024. Secondly, it highlights the future development directions and models of Chinese ecological theology from the perspective of contextual theology.

Aneuploidy with chromosome instability is a cancer hallmark. We studied chromosome 7 copy number variation in gliomas and in primary cultures derived from them. We found tumor heterogeneity with cells having Chr7-CNV commonly occurs in gliomas, with a higher percentage of cells in high-grade gliomas carrying more than 2 copies of Chr7, as compared to low-grade gliomas. Interestingly, all Chr7-aneuploid cell types in the parental culture of established glioma cell lines reappeared in single-cell-derived subcultures. We then characterized the biology of three syngeneic glioma cultures dominated by different Chr7-aneuploid cell types. We found phenotypic divergence for cells following Chr7 missegregation, which benefited overall tumor growth in vitro and in vivo. Mathematical modeling suggested the involvement of chromosome instability and interactions among cell subpopulations in restoring the optimal equilibrium of tumor cell types. Both our experimental data and mathematical modeling demonstrated that the complexity of tumor heterogeneity could be enhanced by the existence of chromosomes with structural abnormality, in addition to their mis-segregations. Overall, our findings show, for the first time, the involvement of chromosome instability in maintaining tumor heterogeneity, which underlies the enhanced growth, persistence and treatment resistance of cancers. © 2013 Hu et al.