Jaegwon Kim

(1934 - 2019)

© 2015 Elsevier Inc.The breakthrough of induced pluripotent stem cell technology has raised the possibility that patient-specific iPSCs may become a renewable source of autologous cells for cell therapy without the concern of immune rejection. However, the immunogenicity of autologous human iPSC -derived cells is not well understood. Using a humanized mouse model reconstituted with a functional human immune system, we demonstrate that most teratomas formed by autologous integration-free hiPSCs exhibit local infiltration of antigen-specific T cells and associated tissue necrosis, indicating immune rejection of certain hiPSC-derived cells. In this context, autologous hiPSC-derived smooth muscle cells appear to be highly immunogenic, while autologous hiPSC-derived retinal pigment epithelial cells are immune tolerated even in non-ocular locations. This differential immunogenicity is due in part to abnormal expression of immunogenic antigens in hiPSC-derived SMCs, but not in hiPSC-derived RPEs. These findings support the feasibility of developing hiPSC-derived RPEs for treating macular degeneration.

© 2016 American Chemical Society.High quality WSe2 films have been grown on bilayer graphene with layer-by-layer control of thickness using molecular beam epitaxy. The combination of angle-resolved photoemission, scanning tunneling microscopy/spectroscopy, and optical absorption measurements reveal the atomic and electronic structures evolution and optical response of WSe2/BLG. We observe that a bilayer of WSe2 is a direct bandgap semiconductor, when integrated in a BLG-based heterostructure, thus shifting the direct-indirect band gap crossover to trilayer WSe2. In the monolayer limit, WSe2 shows a spin-splitting of 475 meV in the valence band at the K point, the largest value observed among all the MX2 materials. The exciton binding energy of monolayer-WSe2/BLG is found to be 0.21 eV, a value that is orders of magnitude larger than that of conventional three-dimensional semiconductors, yet small as compared to other two-dimensional transition metal dichalcogennides semiconductors. Finally, our finding regarding the overall modification of the electronic structure by an alkali metal surface electron doping opens a route to further control the electronic properties of TMDCs.

© 2015 Elsevier B.V.This article demonstrates an instrumented mouthguard capable of non-invasively monitoring salivary uric acid levels. The enzyme -modified screen printed electrode system has been integrated onto a mouthguard platform along with anatomically-miniaturized instrumentation electronics featuring a potentiostat, microcontroller, and a Bluetooth Low Energy transceiver. Unlike RFID-based biosensing systems, which require large proximal power sources, the developed platform enables real-time wireless transmission of the sensed information to standard smartphones, laptops, and other consumer electronics for on-demand processing, diagnostics, or storage. The mouthguard biosensor system offers high sensitivity, selectivity, and stability towards uric acid detection in human saliva, covering the concentration ranges for both healthy people and hyperuricemia patients. The new wireless mouthguard biosensor system is able to monitor SUA level in real-time and continuous fashion, and can be readily expanded to an array of sensors for different analytes to enable an attractive wearable monitoring system for diverse health and fitness applications.

© 2015 American Chemical Society. We demonstrate straightforward fabrication of highly sensitive biosensor arrays based on field-effect transistors, using an efficient high-throughput, large-area patterning process. Chemical lift-off lithography is used to construct field-effect transistor arrays with high spatial precision suitable for the fabrication of both micrometer- and nanometer-scale devices. Sol-gel processing is used to deposit ultrathin In 2 O 3 films as semiconducting channel layers. The aqueous sol-gel process produces uniform In 2 O 3 coatings with thicknesses of a few nanometers over large areas through simple spin-coating, and only low-temperature thermal annealing of the coatings is required. The ultrathin In 2 O 3 enables construction of highly sensitive and selective biosensors through immobilization of specific aptamers to the channel surface; the ability to detect subnanomolar concentrations of dopamine is demonstrated.

Concerns about the efficacy of consciousness can arise either as part of a broad concern about the efficacy of mentality in general, or as a more specific worry focusing on conscious mental states, or the conscious aspects of mental states. This chapter discusses in detail why the two issues, the general one concerning the mental, and the more specific issue about consciousness, have come to be distinguished and how they relate to each other. It discusses the epiphenomenalist arguments of the nineteenth‐century biologist T. H. The experiments and observations that moved Huxley to embrace epiphenomenalism were basically of the following sort: animals for which we have compelling anatomical evidence that they are not conscious can perform activities of the kind that we normally take to require consciousness. The epiphenomenalist arguments follow only on the assumption that the mental is not reducible to the physical; namely, the assumption that reductionist physicalism has been ruled out.

Rene Descartes's theory of mind is the best known, and most influential, form of mind‐body dualism. This chapter summarizes the major tenets of Cartesian dualism. The dualist view of persons that Descartes defended is a form of substance dualism, the doctrine that there are substances of two fundamentally distinct kinds in this world, namely, minds and bodies and that a human person is a composite of a mind and a body, each an entity in its own right. Dualism of this form contrasts with monism, which holds that all things in the world are substances of one kind. The chapter reviews some considerations that are Cartesian in that they can be traced one way or another to Descartes's Second and Sixth Meditations, and that all are at least Cartesian in spirit.

States of affairs constitute a basic ontological category in Chisholm's metaphysical system, and yield events and propositions as subclasses. Qua events, they enter into causal relations, and qua propositions, they are objects of our intentional attitudes. This paper expounds and critically examines Chisholm's conception of a state of affairs and his constructions of events and propositions. Various difficulties with some of Chisholm's definitions and procedures are pointed out and discussed. The last section contains a set of suggested modifications to the theory to avoid these difficulties.

This Festschrift seeks to honor three highly distinguished scholars in the Department of Philosophy, University of Michigan: William K. Frankena, Charles L. Stevenson, and Richard B. Brandt. Each has made significant con­tributions to the philosophic literature, particularly in the field of ethics. Michigan has been fortunate in having three such original and productive moral philosophers serving on its faculty simultaneously. Yet they stand in a long tradition of excellence, both within the Department and in the University. Let us trace that tradition briefly. The University of Michigan opened in 184l. lts Department of Literature, Science, and the Arts at first resembled a typical American college of that period, with religious and ethical indoctrination playing a central role in course offerings. But when Henry Tappan, a Presbyterian clergyman and Professor of philosophy, became President in 1852, he succeeded in shifting the emphasis from indoctrination to inquiry and scholarship. Though he was dismissed for his policies in 1863, Tappan's efforts to establish a broad and liberal curriculum prevailed. Michigan was to take its place among the leading educational institutions in this country, and to achieve an international reputation as a research center. Several past philosophers are worthy of mention here. George Sylvester Morris, an absolute idealist, joined the Department in 1881, having served from 1870 as Chairman of the Department of Modern Languages and Literature. He assumed the Chairmanship of Philosophy in 1884.