James Davies

In this paper, I will explore the idea of an ontological exhaustion of being with being. That is, I want to think exhaustion along the lines of what Jean-Luc Nancy, in The Fall of Sleep, thinks of as the lulling, rhythmic désoeuvrement of the between, that space of non-origin; an exhaustion which signals what Levinas, in his monumental Otherwise than Being, calls the hither side of being, a beyond all being itself. Starting with an introductory discussion of weariness in Kafka, I will move to an examination of idleness, or fatigue, in the work of Byung-Chul Han. In Han, we find the first indications of an exhaustion which is sited not in the ceaselessness of modern life, but in the stillness of the one whose living is the contemplation of this other ontology. This will lead me to a discussion of Agamben, Jon Fosse’s Septology, and the relationship between uselessness, “destituent potential,” and poiesis. By closely analysing these terms, I will consider the poiesis of impotential as the cipher for the being of the one who neither refuses nor affirms, who is only there at the threshold, and who is exhausted, divested of being. I shall then turn to the lulling to sleep that Nancy explores and discuss what might be the being of that self beyond being, the self who is exhausted with being. The remainder of the paper will then constitute an engagement with Levinas’s Otherwise than Being, linked to Nancy, wherein I will develop the idea that exhaustion takes us to that very hither side of being, beyond essence and substance, beyond the subject, to nothing but the useless self whose form-of-life is its undoing of these very categories of being. I will conclude by returning to Kafka and the possibility for happiness which exhaustion uncovers.

This article argues for a task-based approach to identifying and individuating cognitive systems. The agent-based extended cognition approach faces a problem of cognitive bloat and has difficulty accommodating both sub-individual cognitive systems ("scaling down") and some supra-individual cognitive systems ("scaling up"). The standard distributed cognition approach can accommodate a wider variety of supra-individual systems but likewise has difficulties with sub-individual systems and faces the problem of cognitive bloat. We develop a task-based variant of distributed cognition designed to scale up and down smoothly while providing a principled means of avoiding cognitive bloat. The advantages of the task-based approach are illustrated by means of two parallel case studies: re-representation in the human visual system and in a biomedical engineering laboratory.

This article surveys the distribution of wealth and its relationship to economic inequality more broadly. It shows that wealth inequality is high and contributes significantly to inequality in income and consumption, although higher wealth inequality is not always an indicator of greater inequality in well-being. In particular, welfare state policies can improve the well-being of low income groups while at the same time reducing their incentive to save. This may lead to high observed wealth inequality in places where it would otherwise not be expected, such as some of the Scandinavian countries. More research is needed to better illuminate such connections between public policy and wealth inequality.

Population-level biomedical research has become crucial to the health system’s ability to improve the health of the population. This form of research raises a number of well-documented ethical concerns, perhaps the most significant of which is the inability of the researcher to obtain fully informed specific consent from participants. Two proposed technical solutions to this problem of consent in large-scale biomedical research that have become increasingly popular are meta-consent and dynamic consent. We critically examine the ethical and practical credentials of these proposals and find them lacking. We suggest that the consent problem is not solved by adopting a technology driven approach grounded in a notion of ‘specific’ consent but by taking seriously the role of research governance in combination with broader conceptions of consent. In our view, these approaches misconstrue the rightful location of authority in the way in which population-level biomedical research activities are structured and organized. We conclude by showing how and why the authority for determining the nature and shape of choice making about participation ought not to lie with individual participants, but rather with the researchers and the research governance process, and that this necessarily leads to the endorsement of a fully articulated broad consent approach.

Though often presented as a recent scientific endeavor, synthetic biology began in the 19th century and was a particularly active field in the years preceding the publication of D’Arcy Thompson’s On Growth and Form. Much synthetic biology of the era was devoted to the construction of nonliving chemical systems that would undergo morphogenesis or dynamic behaviors which had been observed in living organisms. The point was to show that “life-like” structure and behavior could be generated by physicochemical laws and required no vitalist element. D’Arcy Thompson’s careful analysis of physicochemical morphogenetic mechanisms as possible explanations of organic form links closely to this way of thinking. In the modern era, when we can genetically engineer cells to undergo specific behaviors, and program cells to undergo simple morphogenetic behaviors of the kind that Thompson and others felt might underly natural morphogenesis, it is possible to test whether they will in fact produce a predictable multicellular shape. This addresses essentially the same questions about the morphogenetic role of physicochemical forces, such as surface tension, but does so “the other way round”: physicochemical mechanisms are not being used as models for morphogenesis by natural cells but rather as a means to engineer cells to make designed forms.

An incoherent visualization is when aspects of different senses of a word are present in the same visualization. We describe and implement a new model of creating contextual coherence in the visual imagination called Coherencer, based on the SOILIE model of imagination. We show that Coherencer is able to generate scene descriptions that are more coherent than SOILIE's original approach as well as a parallel connectionist algorithm that is considered competitive in the literature on general coherence. We also show that co-occurrence probabilities are a better association representation than holographic vectors and that better models of coherence improve the resulting output independent of the association type that is used. Theoretically, we show that Coherencer is consistent with other models of cognitive generation. In particular, Coherencer is a similar, but more cognitively plausible model than the C3 model of concept combination created by Costello and Keane. We show that Coherencer is also consistent with both the modal schematic indices of perceptual symbol systems theory and the amodal contextual constraints of Thagard's theory of coherence. Finally, we describe how Coherencer is consistent with contemporary research on the hippocampus, and we show evidence that the process of making a visualization coherent is serial.

Visual analogy is believed to be important in human problem solving. Yet, there are few computational models of visual analogy. In this paper, we present a preliminary computational model of visual analogy in problem solving. The model is instantiated in a computer program, called Galatea, which uses a language for representing and transferring visual information called Privlan. We describe how the computational model can account for a small slice of a cognitive-historical analysis of Maxwell’s reasoning about electromagnetism.

As a belief source, testimony has long been held by theorists of the mind to play a deeply important role in human cognition. It is unclear, however, just why testimony has been afforded such cognitive importance. We distinguish three suggestions on the matter: the number claim, which takes testimony’s cognitive importance to be a function of the number of beliefs it typically yields, relative to other belief sources; the reliability claim, which ties the importance of testimony to its relative truth-conduciveness; and the scope claim, according to which testimony’s importance is a function of its relative representational power, non-numerically conceived. After laying out these three suggestions, we go on to argue that there is little hope of grounding testimony’s cognitive importance in either the number claim or the reliability claim. We conclude with a tentative exploration of the basis and plausibility of the scope claim.

Many mental phenomena involve thinking about people who do not exist. Imagined characters appear in planning, dreams, fantasizing, imaginary companions, bereavement hallucinations, auditory verbal hallucinations, and as characters created in fictional narratives by authors. Sometimes these imagined persons are felt to be completely under our control, as when one fantasizes about having a great time at a party. Other times, characters feel as though they are outside of our conscious control. Dream characters, for example, are experienced by dreamers as autonomous entities, and often do things that frighten and surprise dreamers. Some imagined persons, such as characters in fiction, start off under conscious control of the author, but over time, can appear to gain an illusion of independent agency. I propose an explanation for different autonomy attributions: characters are by default non-autonomous, unless their personalities are well-practiced. Characters become autonomous because modeling their thinking has become automatized, like many other well-practiced activities.

Much contemporary biology consists of identifying the molecular components that associate to perform biological functions, then discovering how these functions are controlled. The concept of control is key to biological understanding, at least of the physiological kind; identifying regulators of processes underpins ideas of causality and allows complicated, multicomponent systems to be summarized in relatively simple diagrams and models. Unfortunately, as this article demonstrates by drawing on published articles, there is a growing tendency for authors to claim that a molecule is a ‘regulator’ of something on evidence that cannot support the conclusion. In particular, gene knockout experiments, which can demonstrate only that a molecule is necessary for a process, are all too frequently being misinterpreted as revealing regulation. This logical error threatens to blur the important distinction between regulation and mere necessity and therefore to weaken one of our strongest tools for comprehending how organisms work.

Branching morphogenesis of epithelia is an important mechanism in mammalian development. The last decade has seen the identification of many signalling pathways and intracellular mechanisms that control epithelial branching. Tissue‐level mechanisms that space new branches out have, however, remained an unsolved problem. A recent publication by Nelson et al.1 suggests—if extrapolation from their novel and abstract culture system is valid—that branches may be spaced out by a system of mutual inhibition based on diffusion of TGFβ. Such a system would allow a developing tree to arrange itself, without detailed genetic specification, by adaptive self‐organization. BioEssays 29: 205–207, 2007. © 2007 Wiley Periodicals, Inc.

This thesis addresses an issue in the philosophy of Mathematics which is little discussed, and indeed little recognised. This issue is the phenomenon of a ‘change of setting’. Changes of setting are events which involve a change in a scientific framework which is fruitful for answering questions which were, under an old framework, intractable. The formulation of the new setting usually involves a conceptual re-orientation to the subject matter. In the natural sciences, such re-orientations are arguably unremarkable, inasmuch as it is possible that within the former setting for one’s thinking one was merely in error, and under the new orientation one is merely getting closer to the truth of the matter. However, when the subject matter is pure mathematics, a problem arises in that mathematical truth is timelessly immutable. The conceptions that had been settled upon previously seem not the sort of thing that could be vitiated. Yet within a change of setting that is just what seems to happen. Changes of setting, in particular in their effects on the truth of individual propositions, pose a problem for how to understand mathematical truth. Thus this thesis aims to give a philosophical analysis of the phenomenon of changes of setting, in the spirit of the investigations performed in Wilson and Manders and. It does so in three stages, each of which occupies a chapter of the thesis: 1. An analysis of the relationship between mathematical truth and settingchanges, in terms of how the former must be viewed to allow for the latter. This results in a conception of truth in the mathematical sciences which gives a large role to the notion that a mathematical setting must ‘explain itself’ in terms of the problems it is intended to address. 2. In light of, I begin an analysis of the change of setting engendered in mathematical logic by Gottlob Frege. In particular, this chapter will address the question of whether Frege’s innovation constitutes a change of setting, by asking the question of whether he is seeking to answer questions which were present in the frameworks which preceded his innovations. I argue that the answer is yes, in that he is addressing the Kantian question of whether alternative systems of arithmetic are possible. This question arises because it had been shown earlier in the 19th century that Kant’s conclusion, that Euclid’s is the only possible description of space, was incorrect. 3. I conclude with an in-depth look at a specific aspect of the logical system constructed in Frege’s Grundgesetze der Arithmetik. The purpose of this chapter is to find evidence for the conclusions of chapter two in Frege’s technical work. This is necessitated by chapter one’s conclusions regarding the epistemic interdependence of formal systems and informal views of those frameworks. The overall goal is to give a contemporary account of the possibility of setting-changes; it will turn out that an epistemic grasp of a mathematical system requires that one understand it within a broader, somewhat historical context.

Formation of branching epithelial trees from unbranched precursors is a common process in animal organogenesis. In humans, for example, this process gives rise to the airways of the lungs, the urine‐collecting ducts of the kidneys and the excretory epithelia of the mammary, prostate and salivary glands. Branching in these different organs, and in different animal classes and phyla, is morphologically similar enough to suggest that they might use a conserved developmental programme, while being dissimilar enough not to make it obviously certain that they do. In this article, I review recent discoveries about the molecular regulation of branching morphogenesis in the best‐studied systems, and present evidence for and against the idea of there being a highly conserved mechanism. Overall, I come to the tentative conclusion that key mechanisms are highly conserved, at least within vertebrates, but acknowledge that more work needs to be done before the case is proved beyond reasonable doubt. BioEssays 24:937–948, 2002. © 2002 Wiley Periodicals, Inc.