•  846
    Ontology-based knowledge representation of experiment metadata in biological data mining
    with Scheuermann Richard, Kong Megan, Dahlke Carl, Cai Jennifer, Qian Yu, Squires Burke, Dunn Patrick, Wiser Jeff, Hagler Herb, Herb Hagler, Barry Smith, and David Karp
    In Chen Jake & Lonardi Stefano (eds.), Biological Data Mining, Chapman Hall / Taylor and Francis. pp. 529-559. 2009.
    According to the PubMed resource from the U.S. National Library of Medicine, over 750,000 scientific articles have been published in the ~5000 biomedical journals worldwide in the year 2007 alone. The vast majority of these publications include results from hypothesis-driven experimentation in overlapping biomedical research domains. Unfortunately, the sheer volume of information being generated by the biomedical research enterprise has made it virtually impossible for investigators to stay awar…Read more
  •  9
    Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised β-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy (review)
    with H. Wu, L. G. Vincent, Q. Wang, M. Gu, F. Lan, J. M. Churko, K. I. Sallam, E. Matsa, A. Sharma, J. D. Gold, A. J. Engler, Y. K. Xiang, D. M. Bers, and J. C. Wu
    © 2015 Elsevier Inc. β-adrenergic signaling pathways mediate key aspects of cardiac function. Its dysregulation is associated with a range of cardiac diseases, including dilated cardiomyopathy. Previously, we established an iPSC model of familial DCM from patients with a mutation in TNNT2, a sarcomeric protein. Here, we found that the β-adrenergic agonist isoproterenol induced mature β-adrenergic signaling in iPSC-derived cardiomyocytes but that this pathway was blunted in DCM iPSC-CMs. Although…Read more
  •  8
    Treating insomnia improves mood state, sleep, and functioning in bipolar disorder: A pilot randomized controlled trial
    with A. G. Harvey, A. M. Soehner, K. A. Kaplan, K. Hein, J. Kanady, D. Li, S. Rabe-Hesketh, T. A. Ketter, T. C. Neylan, and D. J. Buysse
    © 2015 American Psychological Association.Objective: To determine if a treatment for interepisode bipolar disorder I patients with insomnia improves mood state, sleep, and functioning. Method: Alongside psychiatric care, interepisode bipolar disorder I participants with insomnia were randomly allocated to a bipolar disorder-specific modification of cognitive behavior therapy for insomnia or psychoeducation as a comparison condition. Outcomes were assessed at baseline, the end of 8 sessions of tr…Read more
  •  7
    Human induced pluripotent stem cell-based microphysiological tissue models of myocardium and liver for drug development
    with A. Mathur, P. Loskill, S. Hong, Marcus S. G., L. Dumont, B. R. Conklin, H. Willenbring, L. P. Lee, and K. E. Healy
    Drug discovery and development to date has relied on animal models, which are useful but are often expensive, slow, and fail to mimic human physiology. The discovery of human induced pluripotent stem cells has led to the emergence of a new paradigm of drug screening using human and disease-specific organ-like cultures in a dish. Although classical static culture systems are useful for initial screening and toxicity testing, they lack the organization of differentiated iPS cells into microphysiol…Read more
  •  6
    Androgen receptor and chemokine receptors 4 and 7 form a signaling axis to regulate CXCL12-dependent cellular motility
    with J. J. Hsiao, B. H. Ng, M. M. Smits, J. Wang, R. J. Jasavala, H. D. Martinez, J. J. Alston, H. Misonou, J. S. Trimmer, and M. E. Wright
    © Hsiao et al.; licensee BioMed Central.Background: Identifying cellular signaling pathways that become corrupted in the presence of androgens that increase the metastatic potential of organ-confined tumor cells is critical to devising strategies capable of attenuating the metastatic progression of hormone-naïve, organ-confined tumors. In localized prostate cancers, gene fusions that place ETS-family transcription factors under the control of androgens drive gene expression programs that increas…Read more
  •  5
    The unique properties of lasers create an enormous potential for specific treatment of chronic ear disease. Despite the widespread acceptance and use of the laser, however, a complete understanding of the time- and space-dependent temperature distribution in otic capsule bone immediately after pulsed laser exposure has not been elucidated. Using a liquid nitrogen- cooled mercury-cadmium telluride infrared detector, the temperature distribution in human cadaveric otic capsule bone was determined …Read more
  •  5
    We present noninvasive, quantitative in vivo measurements of methemoglobin formation and reduction in a rabbit model using broadband diffuse optical spectroscopy. Broadband DOS combines multifrequency frequency-domain photon migration with time-independent near infrared spectroscopy to quantitatively measure bulk tissue absorption and scattering spectra between 600 nm and 1,000 nm. Tissue concentrations of methemoglobin, deoxyhemoglobin, and oxyhemoglobin were determined from absorption spectra …Read more
  •  4
    Nrf2 is involved in maintaining hepatocyte identity during liver regeneration
    with Y. Zou, S. M. Nambiar, M. Hu, W. Rui, Q. Bao, J. Y. Chan, and G. Dai
    © 2014 Zou et al. Nrf2, a central regulator of the cellular defense against oxidative stress and inflammation, participates in modulating hepatocyte proliferation during liver regeneration. It is not clear, however, whether Nrf2 regulates hepatocyte growth, an important cellular mechanism to regain the lost liver mass after partial hepatectomy. To determine this, various analyses were performed in wild-type and Nrf2-null mice following PH. We found that, at 60 h post-PH, the vast majority of hep…Read more
  •  3
    © 2016, UNESCO IBE.Using comparative data, this article examines the level and distribution of participation in adult education opportunities among countries that participated in PIAAC. It considers observed cross-country patterns in relation to some mechanisms that drive unequal chances to participate and to some policy issues that surround the provision, governance, and financing of different types of adult learning. It also explores recent policy developments relevant to AE in three selected …Read more
  •  1
    Well developed deformation in Si42
    with S. Takeuchi, M. Matsushita, N. Aoi, P. Doornenbal, K. Li, T. Motobayashi, H. Scheit, D. Steppenbeck, H. Wang, H. Baba, D. Bazin, L. Càceres, H. Crawford, P. Fallon, R. Gernhäuser, J. Gibelin, S. Go, S. Grévy, C. Hinke, C. R. Hoffman, R. Hughes, E. Ideguchi, D. Jenkins, N. Kobayashi, Y. Kondo, R. Krücken, T. Le Bleis, G. Lee, A. Matta, S. Michimasa, T. Nakamura, S. Ota, M. Petri, T. Sako, H. Sakurai, S. Shimoura, K. Steiger, K. Takahashi, M. Takechi, Y. Togano, R. Winkler, and K. Yoneda
    Excited states in Si38,40,42 nuclei have been studied via in-beam γ-ray spectroscopy with multinucleon removal reactions. Intense radioactive beams of S40 and S44 provided at the new facility of the RIKEN Radioactive Isotope Beam Factory enabled γ-γ coincidence measurements. A prominent γ line observed with an energy of 742 keV in Si42 confirms the 2 + state reported in an earlier study. Among the γ lines observed in coincidence with the 2 +→0 + transition, the most probable candidate for the tr…Read more
  • Ontology-based knowledge representation of experiment metadata in biological data mining
    with Scheuermann Richard, Kong Megan, Dahlke Carl, Cai Jennifer, Qian Yu, Squires Burke, Dunn Patrick, Wiser Jeff, Hagler Herb, and Others
    In Scheuermann Richard, Kong Megan, Dahlke Carl, Cai Jennifer, Lee Jamie, Qian Yu, Squires Burke, Dunn Patrick, Wiser Jeff, Hagler Herb & Others (eds.), Biological Data Mining, Boca Raton: Chapman Hall / Taylor and Francis. pp. 529--559. 2009.