•  1
    Potential use of clinical polygenic risk scores in psychiatry – ethical implications and communicating high polygenic risk
    with A. C. Palk, S. Dalvie, A. R. Martin, and D. J. Stein
    Philosophy, Ethics, and Humanities in Medicine 14 (1): 1-12. 2019.
    Psychiatric disorders present distinct clinical challenges which are partly attributable to their multifactorial aetiology and the absence of laboratory tests that can be used to confirm diagnosis or predict risk. Psychiatric disorders are highly heritable, but also polygenic, with genetic risk conferred by interactions between thousands of variants of small effect that can be summarized in a polygenic risk score. We discuss four areas in which the use of polygenic risk scores in psychiatric res…Read more
  •  5
    Potential use of clinical polygenic risk scores in psychiatry – ethical implications and communicating high polygenic risk
    with A. C. Palk, S. Dalvie, A. R. Martin, and D. J. Stein
    Philosophy, Ethics, and Humanities in Medicine 14 (1): 1-12. 2019.
    Psychiatric disorders present distinct clinical challenges which are partly attributable to their multifactorial aetiology and the absence of laboratory tests that can be used to confirm diagnosis or predict risk. Psychiatric disorders are highly heritable, but also polygenic, with genetic risk conferred by interactions between thousands of variants of small effect that can be summarized in a polygenic risk score. We discuss four areas in which the use of polygenic risk scores in psychiatric res…Read more