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    Going malignant: the hypoxia‐cancer connection in the prostate
    with P. W. Hochachka, L. Goldenberg, M. Gleave, and P. Kozlowski
    Bioessays 24 (8): 749-757. 2002.
    The metabolic organization of both normal and malignant prostate cellular phenotypes involves some unusual and surprising features. In particular, both conditions exhibit ratios of NADH/NAD+ and NADPH/NADP+ charactersitic of high oxidative states despite a chronic shortage of O2 in both conditions. In this paper, we observe that, in prostate cancer cells, the oxidizing power of the fatty acid synthesis (FAS) pathway is so large that redox is stabilized more favorably (more oxidized) than in norm…Read more