Javier Sanchez

The Maximum Entropy Production Principle (MEPP) stands out as an overarching principle that rules life phenomena in Nature. However, its explanatory power beyond heuristics remains controversial. On the one hand, the MEPP has been successfully applied principally to non-living systems far from thermodynamic equilibrium. On the other hand, the underlying assumptions to lay the MEPP’s theoretical foundations and range of applicability increase the possibilities of conflicting interpretations. More interestingly, from a metaphysical stance, the MEPP’s philosophical status is hotly debated: does the MEPP passively translate physical information into macroscopic predictions or actively select the physical solution in multistable systems, granting the connection between scientific models and reality? This paper deals directly with this dilemma by discussing natural determination from three angles: (1) Heuristics help natural philosophers to build an ontology. (2) The MEPP’s ontological status may stem from its selection of new forms of causation beyond physicalism. (3) The MEPP’s ontology ultimately depends on the much-discussed question of the ontology of probabilities in an information-theoretic approach and the ontology of macrostates according to the Boltzmannian definition of entropy.

In a recent work (Grasso et al., 2021 ), practitioners of the Integrated Information Theory (IIT) claim to have overcome the weaknesses of causal reductionism in producing a coherent account of causation, as causal reductionism would blatantly conflate causation with prediction and could not answer the question of ‘what caused what.’ In this paper, I reject such a dismissal of causal reductionism since IIT anti-reductionists misunderstand the reductionist stance. The reductionists can still invoke a causal account stemming from the causal power of the universe’s basic units and interactions that, eventually, may lead to structures supporting integrated information. Additionally, I claim that the IIT-inspired misunderstanding of causal reductionism originates from the former’s metaphysical deficit, conflating information with causation. However, as a possible way out, if IIT is complemented with a deeper metaphysical ground, such as nested hylomorphism, an improved argument against causal reductionism can be made to work by invoking formal causality as the ultimate cause of integration in natural systems.

La modernidad se caracteriza por una epistemología que ha conducido a la separación de los saberes. Como consecuencia, tanto la teología protestante como la católica han sufrido la falta de una perspectiva unitaria en su razonar sobre Dios. La cultura postmoderna, aceptando la fragmentariedad, presenta una nueva sensibilidad epistemológica que abre posibilidades prometedoras para el redescubrimiento de la trascendencia. Entre ellas, la dialogicidad intrínseca de la Creación apunta a la vía de la belleza como camino privilegiado que la teología ha de explorar en un sentido descendente y, especialmente, ascendente

IntroductionThe prefrontal cortex plays a crucial role in cognition, particularly in executive functions. Cortical reactivity measured with Transcranial Magnetic Stimulation combined with Electroencephalography is altered in pathological conditions, and it may also be a marker of cognitive status in middle-aged adults. In this study, we investigated the associations between cognitive measures and TMS evoked EEG reactivity and explored whether the effects of this relationship were related to neurofilament light chain levels, a marker of neuroaxonal damage.MethodsFifty two healthy middle-aged adults from the Barcelona Brain Health Initiative cohort underwent TMS-EEG, a comprehensive neuropsychological assessment, and a blood test for NfL levels. Global and Local Mean-Field Power, two measures of cortical reactivity, were quantified after left prefrontal cortex stimulation, and cognition was set as the outcome of the regression analysis. The left inferior parietal lobe was used as a control stimulation condition.ResultsLocal reactivity was significantly associated with working memory and reasoning only after L-PFC stimulation. No associations were found between NfL and cognition. These specific associations were independent of the status of neuroaxonal damage indexed by the NfL biomarker and remained after adjusting for age, biological sex, and education.ConclusionOur results demonstrate that TMS evoked EEG reactivity at the L-PFC, but not the L-IPL, is related to the cognitive status of middle-aged individuals and independent of NfL levels, and may become a valuable biomarker of frontal lobe-associated cognitive function.

IntroductionExcitability of the primary motor cortex measured with TMS has been associated with cognitive dysfunctions in patient populations. However, only a few studies have explored this relationship in healthy adults, and even fewer have considered the role of biological sex.MethodsNinety-seven healthy middle-aged adults completed a TMS protocol and a neuropsychological assessment. Resting Motor Threshold and Long-Interval Intracortical Inhibition were assessed in the left motor cortex and related to attention, episodic memory, working memory, reasoning, and global cognition composite scores to evaluate the relationship between cortical excitability and cognitive functioning.ResultsIn the whole sample, there was a significant association between LICI and cognition; specifically, higher motor inhibition was related to better working memory performance. When the sample was broken down by biological sex, LICI was only associated with working memory, reasoning, and global cognition in men. No associations were found between RMT and cognitive functions.ConclusionGreater intracortical inhibition, measured by LICI, could be a possible marker of working memory in healthy middle-aged adults, and biological sex plays a critical role in this association.

This study analyzes the interests of Spanish audiences in travel magazines within the current context of press consumption. The objectives are to identify the readers' reading frequency and reasons for reading, what contents interest them, and what aspects of the photographs attract them. The methodology involves a structured questionnaire completed by a representative sample of the Spanish population (n=1000). The main results reveal a low reading frequency, great interest in practical information, preference for landscape photography (over the age of 54) and nightlife photography (young people), and indifference regarding the journalistic source of the images. These data provide relevant information on which to adapt travel magazines' content strategy.

In recent years, supported by new scientific evidence, the conceptualization of cognitive reserve has been progressively enriched and now encompasses not only cognitive stimulating activities or educational level, but also lifestyle activities, such as leisure physical activity and socialization. In this context, there is increasing interest in understanding the role of psychological factors in brain health and cognitive functioning. In a previous study, we have found that these factors mediated the relationship between CR and self-reported cognitive functioning. In this study, we have confirmed an association between two important constructs included in the psychological wellbeing and salutogenic models, “purpose in life” and “sense of coherence,” CR, as assessed using a questionnaire, and cognitive functioning, as evaluated using a comprehensive neuropsychological battery. Results from 888 middle-aged healthy participants from the Barcelona Brain Health Initiative indicate that both sense of coherence and CR were positively associated with verbal memory, reasoning and attention, working memory, and global cognition. Moreover, the relation between CR and cognitive functioning in the different domains is partially mediated by SoC. When we controlled for brain integrity, introducing into the model neurofilament light chain measures, the mediator role of SoC was confirmed for reasoning and attention and global cognition. However, purpose in life was not associated with cognitive functioning. These results reveal the central role of the SoC construct, which mediates the association between classic CR estimates and cognitive functions, potentially representing a modifiable target for interventions that aim to promote brain health.

Biometric identity systems are now a prominent feature of contemporary law enforcement, including in Europe. Often advanced on the premise of efficiency and accuracy, they have also been the subject of significant controversy. Much attention has focussed on longer-standing biometric data collection, such as finger-printing and facial recognition, foregrounding concerns with the impact such technologies can have on the nature of policing and fundamental human rights. Less researched is the growing use of voice recognition in law enforcement. This paper examines the case of the recent Speaker Identification Integrated Project, a European wide initiative to create the first international and interoperable database of voice biometrics, now the third largest biometric database at Interpol. Drawing on Freedom of Information requests, interviews and public documentation, we outline the emergence and features of SiiP and explore how voice is recognised and attributed meaning. We understand Speaker Identification Integrated Project as constituting a particular ‘regime of recognition’ premised on the use of soft biometrics to disembed voice in order to optimise for difference. This, in turn, has implications for the nature and scope of law enforcement, people's position in society, and justice concerns more broadly.

In futsal there are two referees on the playing court and their capacity to respond to physical and physiological demands imposed during the game is essential for the success. The futsal characteristics such as size pitch, referees position and rules of games or type of league could impose specific physical efforts probably. The aim of this study were to analyze the physical demands of eight elite referees from seven matches of Spanish Futsal Cup 2020. The physical activity of each referee during the match was monitored with a Local Positioning System, which was installed on futsal pitch where the matches were played. The data differences were evaluated as Paired-Samples T-Test procedure. The results revealed a similar total distance between halves. The zone 3 distance showed a significative decrease during the match in comparison to the first and second halves. The number of high-intensity acceleration and deceleration decreased in the second half of the match. Therefore, the use of the tracking device to monitoring physical performance provides knowledge of the specific activity profile from futsal referees. This information to can be useful to design more accurate the training programs.

The aim of this study was to evaluate the neuromuscular response to an agility and repeated sprint ability test according to the level of competition in futsal players. A total of 33 players from two elite teams and one amateur team participated in the study. The participants completed an agility t-test, a 30 m-speed test, and a RSA test. A countermovement jump test and a tensiomyography test of the rectus femoris and biceps femoris of both legs were carried out before and after the tests. RSA test revealed better sprint times in elite players compared to amateurs in the seven bouts, as well as in the 30 m sprint and in the agility test. In conclusion, elite players showed greater performance in the RSA test, in the 30 m tests and in the agility test compared to amateur players. The contractile properties were not a key factor in the RSA performance of the futsal players.

The philosopher Roberto Unger and the physicist Lee Smolin have recently argued that the current explanatory framework of cosmology, which presumes a timeless background of unchanging physical laws, should be replaced by a thoroughly relational framework in which time is fundamental and all laws are subject to change. Within this alternative framework, however, Unger and Smolin find themselves confronted by a dilemma: either the laws of nature evolve according to some higher set of “meta-laws,” which reinstates a timeless background at a higher level, or the laws of nature evolve randomly and the path of inquiry is blocked. In response to this dilemma, the authors propose a theory of causal events as singular, freely chosen, and self-determined optimalities constrained only by their intrinsic relations to all other events.