J. C. Rodriguez

In general, existential threats are those that may potentially result in the extinction of the entire human species, if not significantly endanger its living population. Among the said threats include, but not limited to, pandemics and the impacts of a technological singularity. As regards pandemics, significant work has already been done on how to mitigate, if not prevent, the aftereffects of this type of disaster. For one, certain problem areas on how to properly manage pandemic responses have already been identified, like the following: (a) not being able to learn from previous experiences, (b) the inability to act on warning signals, and (c) the failure to reach a global consensus on a problem (i.e., in a timely manner). In terms of a singularity, however, it may be said that further research is still needed, specifically on how to aptly respond to its projected negative outcomes. In this paper, by treating the three problem areas noted above as preliminary assessment measures of a country’s capacity to coordinate a national response to large-scale disasters, we examine the readiness of the Philippines in preparing for an intelligence explosion. By citing certain instances of how the said country, specifically its national government, faced the coronavirus disease 2019 pandemic, it puts forward the idea that the likely Philippine disaster response towards a singularity needs to be worked on, appealing for a more comprehensive assessment of such for a more informed response plan.

Este texto surge de un intercambio epistolar mantenido con David Armstrong a propósito de su libro Universals. An Opinionated lntroduction. Se presenta en forma de diálogo y ha sido dividido en seis temas. El primero trata el problema de si las diferentes teorías ontológicas, al postular diferentes relaciones básicas, se hallan también en diferentes condiciones para afrontar el argumento del regreso infinito planteado por Bradley. El segundo presenta una duda. Los universales que postula Armstrong, tales como masa, carga electromagnética, etc., son "agregativos": admiten la categoría de cantidad. Pero se supone que los universales no admiten dicha categoría. Pareciera, pues, que los "universales" postulados por Armstrong no constituyen auténticos universales. El tercer tema concierne a la relación entre la teoría del haz y el Principio de identidad de los indiscernibles. El cuarto trata la opinión de Armstrong según la cual la teoría del haz se vería obligada a postular el carácter autosubsistente de los universales. El quinto consiste en la discusión acerca de si la teoría del haz debe admitir la existencia de hechos. Finalmente, el sexto concierne a la naturaleza de los tropos. This text originates in an exchange of letters I held with David Armstrong when his book Universals. An Opinionated Introduction was published. It is offered as a dialogue and has been divided into six topics. The first one deals with the problem of whether different ontological theories, which posit different basic relations, are also differently prepared to deal with Bradley's infinito regress argument. The second one raises a doubt. Those universals posited by Armstrong, such as mass, electric charge, etc., are "aggregative", which means they are subject to the category of quantity. But universals are not supposed to differ quantitatively. Thus, those "universals" favored by Armstrong become suspect of not being real universals. The third one addresses the relation between the Bundle Theory and the Identity of Indiscernibles. The fourth one deals with Armstrong's opinion according to which the bundle theorist is forced to conceive of universals as self subsistant entities. The fifth one discusses whether the Bundle Theory has to accept the existence of facts. Finally, the sixth one deals with tropes

En What Emotions Really Are y en otros artículos, Griffiths afirma que las clases naturales de los organismos vivos en Biología son cladistas. La afirmación está inmersa en una nueva teoría acerca de las clases naturales. En este trabajo examinaré los argumentos esgrimidos por Griffiths para sostener el estatus privilegiado de las clasificaciones cladistas frente a otras clasificaciones. No se discutirá la teoría de las clases naturales ofrecida, de cuyos méritos no dudo, sino su capacidad para ofrecer una solución en la cuestión particular de qué sistema de clasificación de organismos debería utilizarse en Biología. In What emotions really are and in other papers Griffiths states that in Biology, natural classes ofliving organisms are clades. This assertion is made within the bounds of a new theory of natural classes. In this paper I wiIl consider the arguments employed by Griffiths to support the privileged status of the cladistic classification over other classifications. It is not Griffith's theory of natural classes what will be discussed, but his ability to offer a solution to the particular issue ofwhich classification system of organisms should be used in Biology

En What Emotions Really Are y en otros artículos, Griffiths afirma que las clases naturales de los organismos vivos en Biología son cladistas. La afirmación está inmersa en una nueva teoría acerca de las clases naturales. En este trabajo examinaré los argumentos esgrimidos por Griffiths para sostener el estatus privilegiado de las clasificaciones cladistas frente a otras clasificaciones. No se discutirá la teoría de las clases naturales ofrecida, de cuyos méritos no dudo, sino su capacidad para ofrecer una solución en la cuestión particular de qué sistema de clasificación de organismos debería utilizarse en Biología. In What emotions really are and in other papers Griffiths states that in Biology, natural classes ofliving organisms are clades. This assertion is made within the bounds of a new theory of natural classes. In this paper I wiIl consider the arguments employed by Griffiths to support the privileged status of the cladistic classification over other classifications. It is not Griffith's theory of natural classes what will be discussed, but his ability to offer a solution to the particular issue ofwhich classification system of organisms should be used in Biology

En What Emotions Really Are y en otros artículos, Griffiths afirma que las clases naturales de los organismos vivos en Biología son cladistas. La afirmación está inmersa en una nueva teoría acerca de las clases naturales. En este trabajo examinaré los argumentos esgrimidos por Griffiths para sostener el estatus privilegiado de las clasificaciones cladistas frente a otras clasificaciones. No se discutirá la teoría de las clases naturales ofrecida, de cuyos méritos no dudo, sino su capacidad para ofrecer una solución en la cuestión particular de qué sistema de clasificación de organismos debería utilizarse en Biología. In What emotions really are and in other papers Griffiths states that in Biology, natural classes ofliving organisms are clades. This assertion is made within the bounds of a new theory of natural classes. In this paper I wiIl consider the arguments employed by Griffiths to support the privileged status of the cladistic classification over other classifications. It is not Griffith's theory of natural classes what will be discussed, but his ability to offer a solution to the particular issue ofwhich classification system of organisms should be used in Biology

Este trabajo contiene tres diferentes tipos de objeciones al famoso "argumento del lenguaje privado" de Wittgenstein. Primero ofrezco una reconstrucción posible del argumento. Luego, como primera objeción, e inspirándome en H. N. Castañeda, presento casos donde, contra la opinión de Wittgenstein, el sujeto corrige sus propios errores basándose en distintos criterios subjetivos A continuación, como una segunda objeción, presento situaciones hipotéticas destinadas a mostrar que las experiencias subjetivas, aún si fuesen privadas, podrían en principio ser intersubjetivamente testeadas, si bien en forma indirecta, tal como lo son las entidades inobservables de la ciencia. Finalmente, como tercera objeción, pongo en duda un supuesto básico del cartesianismo sobre el cual descansa el argumento del lenguaje privado. Este supuesto es la conocida tesis de la privacidad de la experiencia subjetiva. Mi argumento contra esta tesis se basa en los casos de bisección cerebral estudiados por T. Nagel, M. Lockwood y otros. This paper contains three different kinds of objections to Wittgenstein's famous "private language argument". First I offer a possible reconstruction of the argument. Then, as a first objection, drawing my ideas from H.N Castañeda, I present cases where, against Wittgenstein's opinion, the subject corrects his own errors based on different subjective criteria. Afterwards, as a second objection, I offer hypothetical examples in order to show that subjective experiences, even is they were private, could in principle be intersubjectively tested, although in a indirect way, as the unobservable entities of science are. Finally, as a third point, I challenge a basic presupposition of Cartesianism on which the private language argument rests. This presupposition is the well known thesis of the essential privacy of subjective experience. My argument against this thesis is based on the split-brain cases, studied by T. Nagel, M. Lockwood and others

The advancement of Artificial Intelligence (AI) poses challenges in the field of bioethics, especially concerning issues related to life and death. AI has permeated areas such as health and research, generating ethical dilemmas and questions about privacy, decision-making, and access to technology. Life and death have been recurring human concerns, particularly in connection with depression. AI has created systems like Thanabots or Deadbots, which digitally recreate deceased individuals and allow interactions with them. These systems rely on information generated by AI users during their lifetime, raising ethical and emotional questions about the authenticity and purpose of these recreations. AI acts as a mediator between life, death, and the human being, enabling a new form of communication with the deceased. However, this raises ethical issues such as informed consent from users and the limits of digital recreation. Companies offer services like the Digital Resurrection of deceased individuals and the generation of hyper-realistic avatars. Still, concerns arise about the authenticity of these representations and their long-term emotional impact. Interaction with Thanabots may alter perceptions of death and finitude, leading to a potential “postmortal society” where death is no longer viewed as a definitive end. Nevertheless, this raises questions about the value of life and the authenticity of human experiences. AI becomes a bridge between the living and the dead, partially replacing rituals and mystical beliefs. As technology advances, there will be a need for greater transparency in interacting with AI systems and ethical reflections on the role of these technologies in shaping perceptions of life and death. Ultimately, the question arises of whether we should allow the dead to rest in peace and how to balance the pursuit of emotional relief with authenticity and respect for the memory of the deceased. A deeper ethical consideration is needed on how AI alters traditional notions of life, death, and communication in contemporary society. In this research, an interdisciplinary approach was utilized to conduct a comprehensive systematic review of the recent academic literature, followed by a detailed analysis of two key texts. Central ideas were extracted, and recurring themes were identified. Finally, a reflective analysis of the findings was conducted, yielding significant conclusions and recommendations for future research.

Sufficientarianism is a prominent approach to distributive justice in political philosophy and in policy analyses. However, it is virtually absent from the formal normative economics literature. We analyze sufficientarianism axiomatically in the context of the allocation of 0–1 normalized well-being in society. We present three characterizations of the core sufficientarian criterion, which counts the number of agents who attain a “good enough” level of well-being. The main characterization captures the “hybrid” nature of the criterion, which embodies at the same time a threshold around which the worst off in society is prioritized, and an indifference to equality in other regions. The other two characterizations relate sufficientarianism, respectively, to a liberal principle of noninterference and to a classic neutrality property.

Este artículo tiene el objetivo de dilucidar el contexto, contenido y propósito general de las críticas que Agnes Heller (1929-2019) planteó sobre las filosofías de la historia. Para tal efecto, se revisan algunos de los postulados de estas con el fin de destacar cómo Heller, a propósito del contexto político en el que vivió, volvió su mirada hacia esas filosofías con el fin de escrutar los vínculos que, a su parecer, se tejían entre ellas y los regímenes totalitarios que se forjaron durante el siglo xx. Al respecto, se argumenta que las reflexiones de la autora no se orientaron solamente a dar cuenta de dicha cuestión, sino que, como resultado de su esmerada labor intelectual, de sus convicciones morales y de su propia experiencia personal, encaminó sus esfuerzos hacia la elaboración de una sugerente concepción de la historia que se fundamentó en criterios y principios éticos.

Despite abundant evidence associating CD38 overexpression and CD4 T cell depletion in HIV infection, no causal relation has been investigated. To address this issue, a series of mechanisms are proposed, supported by evidence from different fields, by which CD38 overexpression can facilitate CD4 T cell depletion in HIV infection. According to this model, increased catalytic activity of CD38 may reduce CD4 T cells’ cytoplasmic nicotin‐amide adenine dinucleotide (NAD), leading to a chronic Warburg effect. This will reduce mitochondrial function. Simultaneously, CD38's catalytic products ADPR and cADPR may be transported to the cytoplasm, where they can activate calcium channels and increase cytoplasmic Ca2+ concentrations, further altering mitochondrial integrity. These mechanisms will decrease the viability and regenerative capacity of CD4 T cells. These hypotheses can be tested experimentally, and might reveal novel therapeutic targets.

According to political minimalism, a debate is considered political when it revolves around the question “What shall we do?” This account suggests that certain issues related to human enhancement technologies (HETs), which have traditionally been addressed in the realm of applied ethics, could be better approached from a political standpoint. However, this raises the question of who constitutes the “we” – the communities that face the political challenges posed by HETs. We argue that there is a global human community that directly faces at least some of these challenges, and this fact underscores the relevance of a cosmopolitan perspective. While some authors have already advocated for a cosmopolitan approach in addressing issues such as poverty or climate change, they often do so from a moral outlook, without adequately distinguishing between ethics and politics. In contrast, we assert that HETs present compelling arguments in favour of cosmopolitanism as a political stance. In support of this claim, we consider two cases: the pills that would allow people to eat at will without gaining weight, and the choice between different types of cognitive enhancers.