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    © 2015 Macmillan Publishers Limited. Matrix stiffness potently regulates cellular behaviour in various biological contexts. In breast tumours, the presence of dense clusters of collagen fibrils indicates increased matrix stiffness and correlates with poor survival. It is unclear how mechanical inputs are transduced into transcriptional outputs to drive tumour progression. Here we report that TWIST1 is an essential mechanomediator that promotes epithelial-mesenchymal transition in response to inc…Read more
  •  5
    Lipidomic Analysis of Oxidized Fatty Acids in Plant and Algae Oils
    with C. E. Richardson, M. Hennebelle, Y. Otoki, D. Zamora, B. D. Hammock, and A. Y. Taha
    © 2017 American Chemical Society.Linoleic acid and a-linolenic acid in plant or algae oils are precursors to oxidized fatty acid metabolites known as oxylipins. Liquid chromatography tandem mass spectrometry was used to quantify oxylipins in soybean, corn, olive, canola, and four high-oleic acid algae oils at room temperature or after heating for 10 min at 100 °C. Flaxseed oil oxylipin concentrations were determined in a follow-up experiment that compared it to soybean, canola, corn, and olive o…Read more
  •  5
    Impact of neighborhood and individual socioeconomic status on survival after breast cancer varies by race/ethnicity: The neighborhood and breast cancer study
    with S. Shariff-Marco, John E. M., M. Sangaramoorthy, A. Hertz, J. Koo, D. O. Nelson, C. W. Schupp, S. J. Shema, M. Cockburn, W. A. Satariano, I. H. Yen, N. A. Ponce, M. Winkleby, T. H. M. Keegan, and S. L. Gomez
    Background: Research is limited on the independent and joint effects of individual- and neighborhood-level socioeconomic status on breast cancer survival across different racial/ethnic groups. Methods: We studied individual-level SES, measured by self-reported education, and a composite neighborhood SES measure in females, ages 18 to 79 years and diagnosed 1995 to 2008, in the San Francisco Bay Area. We evaluated all-cause and breast cancer-specific survival using stage-stratified Cox proportion…Read more
  •  4
    Outcomes after diagnosis of mycosis fungoides and Sézary syndrome before 30 years of age: A population-based study
    with W. Z. Ai, T. H. Keegan, D. J. Press, L. B. Pincus, Y. H. Kim, and E. T. Chang
    IMPORTANCE: Mycosis fungoides and Sézary syndrome are rare in children and young adults, and thus the incidence and outcomes in this patient population are not well studied. OBJECTIVE: To assess the incidence and outcomes of MF/SS in patients diagnosed before 30 years of age. DESIGN, SETTING, AND PARTICIPANTS: Retrospective study of 2 population-based cancer registries - the California Cancer Registry and 9 US cancer registries of the Surveillance, Epidemiology, and End Results program - for pat…Read more