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    Central inhibitory dysfunctions: Mechanisms and clinical implications
    with Z. Wiesenfeld-Hallin, H. Aldskogius, G. Grant, T. Hökfelt, and X.-J. Xu
    Behavioral and Brain Sciences 20 (3): 420-425. 1997.
    Injury to the central or peripheral nervous system is often associated with persistent pain. After ischemic injury to the spinal cord, rats develop severe mechanical allodynia-like symptoms, expressed as a pain-like response to innocuous stimuli. In its short-lasting phase the allodynia can be relieved with the [gamma]-aminobutyric acid (GABA)-B receptor agonist baclofen, which also reverses the hyperexcitability of dorsal horn interneurons to mechanical stimuli. Furthermore, there is a reductio…Read more
  •  8
    Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2
    with X. Liang, H. C. Chien, S. W. Yee, M. M. Giacomini, E. C. Chen, M. Piao, J. Twelves, E. I. Lepist, A. S. Ray, and K. M. Giacomini
    © 2015 American Chemical Society.The biguanide metformin is widely used as first-line therapy for the treatment of type 2 diabetes. Predominately a cation at physiological pH's, metformin is transported by membrane transporters, which play major roles in its absorption and disposition. Recently, our laboratory demonstrated that organic cation transporter 1, OCT1, the major hepatic uptake transporter for metformin, was also the primary hepatic uptake transporter for thiamine, vitamin B1. In this …Read more