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    Defining the role of common variation in the genomic and biological architecture of adult human height
    with A. R. Wood, T. Esko, S. Vedantam, T. H. Pers, S. Gustafsson, A. Y. Chu, K. Estrada, J. Luan, Z. Kutalik, N. Amin, M. L. Buchkovich, D. C. Croteau-Chonka, F. R. Day, Y. Duan, T. Fall, R. Fehrmann, T. Ferreira, A. U. Jackson, J. Karjalainen, K. S. Lo, A. E. Locke, R. Mägi, E. Mihailov, E. Porcu, J. C. Randall, A. Scherag, A. A. E. Vinkhuyzen, H. J. Westra, T. W. Winkler, T. Workalemahu, J. H. Zhao, D. Absher, E. Albrecht, D. Anderson, J. Baron, M. Beekman, A. Demirkan, G. B. Ehret, B. Feenstra, M. F. Feitosa, K. Fischer, R. M. Fraser, A. Goel, J. Gong, A. E. Justice, S. Kanoni, M. E. Kleber, K. Kristiansson, U. Lim, V. Lotay, J. C. Lui, M. Mangino, I. M. Leach, C. Medina-Gomez, M. A. Nalls, D. R. Nyholt, C. D. Palmer, D. Pasko, S. Pechlivanis, I. Prokopenko, J. S. Ried, S. Ripke, D. Shungin, A. Stancáková, R. J. Strawbridge, Y. J. Sung, T. Tanaka, A. Teumer, S. Trompet, S. W. Van Der Laan, J. Van Setten, J. V. Van Vliet-Ostaptchouk, Z. Wang, L. Yengo, W. Zhang, U. Afzal, J. Ärnlöv, G. M. Arscott, S. Bandinelli, A. Barrett, C. Bellis, A. J. Bennett, C. Berne, and B.
    © 2014 Nature America, Inc. All rights reserved. Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated 1/42,000, 1/43,700 and 1/49,500 SNPs explained 1/421%, 1/424% and 1/429% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability.…Read more