Jon Baron

© 2014 Nature America, Inc. All rights reserved. Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated 1/42,000, 1/43,700 and 1/49,500 SNPs explained 1/421%, 1/424% and 1/429% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/I 2-catenin and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number of causal variants.

Cognitive biases that affect decision making may affect the decisions of citizens that influence public policy. To the extent that decisions follow principles other than maximizing utility for all, it is less likely that utility will be maximized, and the citizens will ultimately suffer the results. Here I outline some basic arguments concerning decisions by citizens, using voting as an example. I describe two types of values that may lead to sub-optimal consequences when these values influence political behavior: moralistic values (which people are willing to impose on others regardless of the consequences) and protected values (PVs, values protected from trade-offs). I present evidence against the idea that voting is expressive, i.e., that voters aim to express their moral views rather than to have an effect on outcomes. I show experimentally that PVs are often moralistic. Finally, I present some data that citizens’ think of their duty in a parochial way, neglecting out-groups. I conclude that moral judgments are important determinants of citizen behavior, that these judgments are subject to biases and based on moralistic values, and that, therefore, outcomes are probably less good than they could be.