Jonathan Davies

Beliefs about hypothetical situations need to be 'quarantined' from factual representations, so that our inference processes do not make false conclusions about the real world. Nichols argued for the existence of a place where these special beliefs are kept: the pretence box. We show that this theory has a number of drawbacks, including its inability to account for simultaneously keeping track of multiple imagined worlds. We offer an explanation that remedies these problems: beliefs of content imagination each belong to some number of microtheories; systems of ideas tagged as being true or false only in certain contexts.

Synthetic biology is an increasingly high-profile area of research that can be understood as encompassing three broad approaches towards the synthesis of living systems: DNA-based device construction, genome-driven cell engineering and protocell creation. Each approach is characterized by different aims, methods and constructs, in addition to a range of positions on intellectual property and regulatory regimes. We identify subtle but important differences between the schools in relation to their treatments of genetic determinism, cellular context and complexity. These distinctions tie into two broader issues that define synthetic biology: the relationships between biology and engineering, and between synthesis and analysis. These themes also illuminate synthetic biology's connections to genetic and other forms of biological engineering, as well as to systems biology. We suggest that all these knowledge-making distinctions in synthetic biology raise fundamental questions about the nature of biological investigation and its relationship to the construction of biological components and systems.