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    The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases
    with T. R. Katsumoto, M. Kudo, C. Chen, A. Sundaram, E. C. Callahan, J. W. Zhu, C. E. Rosen, B. N. Manz, J. W. Lee, M. A. Matthay, X. Huang, D. Sheppard, and A. Weiss
    Increased airway smooth muscle contractility and the development of airway hyperresponsiveness are cardinal features of asthma, but the signaling pathways that promote these changes are poorly understood. Tyrosine phosphorylation is tightly regulated by the opposing actions of protein tyrosine kinases and phosphatases, but little is known about whether tyrosine phosphatases influence AHR. Here, we demonstrate that genetic inactivation of receptor-like protein tyrosine phosphatase J, which encode…Read more