Lee Lin

© 2015 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. Solute carrier transporters — a family of more than 300 membrane-bound proteins that facilitate the transport of a wide array of substrates across biological membranes — have important roles in physiological processes ranging from the cellular uptake of nutrients to the absorption of drugs and other xenobiotics. Several classes of marketed drugs target well-known SLC transporters, such as neurotransmitter transporters, and human genetic studies have provided powerful insight into the roles of more-recently characterized SLC transporters in both rare and common diseases, indicating a wealth of new therapeutic opportunities. This Review summarizes knowledge on the roles of SLC transporters in human disease, describes strategies to target such transporters, and highlights current and investigational drugs that modulate SLC transporters, as well as promising drug targets.

We provide a critical assessment of the account of causal emergence presented in Erik Hoel’s 2017 article “When the map is better than the territory”. The account integrates causal and information theoretic concepts to explain under what circumstances there can be causal descriptions of a system at multiple scales of analysis. We show that the causal macro variables implied by this account result in interventions with significant ambiguity, and that the operations of marginalization and abstraction do not commute. Both of these are desiderata that, we argue, any account of multi-scale causal analysis should be sensitive to. The problems we highlight in Hoel’s definition of causal emergence derive from the use of various averaging steps and the introduction of a maximum entropy distribution that is extraneous to the system under investigation.

This paper aims to explore the appropriation of Deleuzian literary theory in the Chinese context and its potential for mapping a new global poetics. The purpose of this treatment is thus twofold: first, it will redefine the East–West literary relationship, and second, it will seek a new ethics of life, as endorsed by Deleuze's philosophy of immanence. One finds an affinity between literature and life in Deleuze's philosophy: in short, literature appears as the passage of life and an enterprise of health and thus seeks new possibilities of life, which consists in the invention of a new language and a new people. But what kind of health may such a view provide for a non-Western individual, people, literature and culture? This investigation further appeals to the medium of translation. This paper argues that the act of translation functions as a means of deterritorialisation that displays continuing variations of a language, and through translation, Deleuze's clinical and critical aspects of literature promote a transversal poetics that transcends the binary, oppositional conception of East–West and an immanent ethics of life that overcomes the sentiment of ressentiment.