Lin Liu

Sometimes, especially in familiar tool use, our intentions concern only distal effects on external objects, not our bodily movements. Yet we still succeed in selecting the appropriate bodily movements. How is this possible? This question relates to the interface problem in the philosophy of mind and action, which asks how intentions and motor representations—each with distinct representational formats—coordinate. Although our question is not its main focus, many proposed solutions to the interface problem imply that bodily movements must be represented in intention in order to be selected. If so, they cannot explain the phenomenon at hand—and thus cannot offer a satisfactory answer to the question of how intentions control the body. I argue that research on the ideomotor principle suggests an alternative route: intentions can give rise to imagery of the effects that bodily movements produce on external objects, and such imagery can in turn trigger the appropriate motor representations. Because this pathway allows representations of distal effects to mediate between intention and motor systems, it better explains how bodily actions are selected even when they are not represented in intentions. While some may object that this account relies on translation processes—often viewed with suspicion—I will argue that this aversion is unfounded and that such processes need not be rejected.

Lifelong premature ejaculation (LPE) is a common male sexual dysfunction. Lack of active control for rapid ejaculation brought great distress to sexual harmony, and even fertility. Previous neurophysiology studies revealed an ejaculation-related control mechanism in the brain. However, it remains unclear whether this inhibitory network is altered in LPE patients. The present study investigated the central inhibitory network function of LPE patients by using stop signal task-related functional magnetic resonance imaging and resting-state functional connectivity analysis. The results showed no difference in task-related behavioral performance or neural activation during response inhibition between LPE patients and controls. However, LPE patients showed a significantly different correlation pattern between the stop signal reaction time (SSRT) and left inferior frontal gyrus activation during successful inhibition, in which a typical negative correlation between SSRT and the activation was completely disappeared in patients. In addition, using the left inferior frontal gyrus as a seed, patients showed weaker functional connectivity between the seed and two areas (left dental nucleus and right frontal pole) compared with controls. These data suggest that LPE patients have an abnormal brain control network, which may contribute to the reduced central control of rapid ejaculation. This study provides new insights into the neural mechanism of LPE involving the central inhibitory network, which may offer an underlying intervention target for future treatment.

Competition for land is increasing as demand for multiple land uses and ecosystem services rises. Land regulation of the principles of landscape ecology is necessary to develop more sustainable approaches to land use planning. The research evaluated the present land patterns and determined best practices for its regulation of Dongwang Township in Quyang County, located in the Taihang Mountain area of Hebei Province, China. The research used the landscape ecology theory to construct an index system for landscape pattern analysis based on the GIS and Fragstats 3.3 software. In this study, we examined the specific reasons that landscape ecology is superior to traditional methods in land consolidation planning and design, which is conducive to the comprehensive development of land ecological benefits. Landscape ecological planning can effectively reduce landscape fragmentation and improve intensive management. The result found that the descending order of the Shannon index was current landscape, landscape ecological planning, and traditional planning. Landscape ecological planning could protect the natural diversity than traditional planning. Landscape ecological planning enables the creation of long corridors, with higher densities and connectivity and lower average corridor widths than traditional planning. Besides, it can improve ecological service function values in the study area to varying degrees, thus discouraging residents from limiting themselves to grain production. This research has great potential to improve the visibility of ecosystem services in local land use planning and, thus, to improve the ecological functioning of future landscapes.

Computational approaches in systems biology have become a powerful tool for understanding the fundamental mechanisms of cellular metabolism and regulation. However, the interplay between the regulatory and the metabolic system is still poorly understood. In particular, there is a need for formal mathematical frameworks that allow analyzing metabolism together with dynamic enzyme resources and regulatory events. Here, we introduce a metabolic-regulatory network model that allows integrating metabolism with transcriptional regulation, macromolecule production and enzyme resources. Using this model, we show that the dynamic interplay between these different cellular processes can be formalized by a hybrid automaton, combining continuous dynamics and discrete control.