•  25
    Interface reactions in a chromium buffer layer deposited between stainless steel and a silicon substrate
    with J. Y. Huang *, S. Chen, D. Z. Wang, S. H. Jo, W. Z. Li, and Z. F. Ren *
    Philosophical Magazine 85 (14): 1459-1471. 2005.
  •  2
    Three-dimensional structural dynamics and fluctuations of DNA-nanogold conjugates by individual-particle electron tomography
    with D. Lei, J. M. Smith, M. Zhang, H. Tong, X. Zhang, Z. Lu, J. Liu, A. P. Alivisatos, and G. Ren
    DNA base pairing has been used for many years to direct the arrangement of inorganic nanocrystals into small groupings and arrays with tailored optical and electrical properties. The control of DNA-mediated assembly depends crucially on a better understanding of three-dimensional structure of DNA-nanocrystal-hybridized building blocks. Existing techniques do not allow for structural determination of these flexible and heterogeneous samples. Here we report cryo-electron microscopy and negative-st…Read more
  •  3
    Cholesteryl ester transfer protein mediates cholesteryl ester transfer from the atheroprotective high density lipoprotein cholesterol to the atherogenic low density lipoprotein cholesterol. In the past decade, this property has driven the development of CETP inhibitors, which have been evaluated in large scale clinical trials for treating cardiovascular diseases. Despite the pharmacological interest, little is known about the fundamental mechanism of CETP in CE transfer. Recent electron microsco…Read more
  • 3D Structural Fluctuation of IgG1 Antibody Revealed by Individual Particle Electron Tomography
    with X. Zhang, H. Tong, B. Peng, M. J. Rames, S. Zhang, and G. Ren
    Commonly used methods for determining protein structure, including X-ray crystallography and single-particle reconstruction, often provide a single and unique three-dimensional structure. However, in these methods, the protein dynamics and flexibility/fluctuation remain mostly unknown. Here, we utilized advances in electron tomography to study the antibody flexibility and fluctuation through structural determination of individual antibody particles rather than averaging multiple antibody particl…Read more