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    Feasibility of three-dimensional optical coherence tomography and optical Doppler tomography of malignancy in hamster cheek pouches
    with P. E. Wilder-Smith, N. M. Hanna, W. Waite, K. Taylor, W. G. Jung, D. Mukai, E. Matheny, K. Kreuter, and Z. Chen
  • We present noninvasive, quantitative in vivo measurements of methemoglobin formation and reduction in a rabbit model using broadband diffuse optical spectroscopy. Broadband DOS combines multifrequency frequency-domain photon migration with time-independent near infrared spectroscopy to quantitatively measure bulk tissue absorption and scattering spectra between 600 nm and 1,000 nm. Tissue concentrations of methemoglobin, deoxyhemoglobin, and oxyhemoglobin were determined from absorption spectra …Read more
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    In vivo multiphoton fluorescence imaging: A novel approach to oral malignancy
    with P. Wilder-Smith, K. Osann, N. Hanna, N. El Abbadi, D. Messadi, and T. Krasieva
    Background and Objective: Current techniques for oral diagnosis require surgical biopsy of lesions, and may fail to detect early malignant change. Non-invasive, sensitive tools providing early detection of oral cancer and a better understanding of malignant change are needed. These studies evaluated in vivo multiphoton excited fluorescence techniques to map epithelial and subepithelial changes through out oral carcinogenesis and serve as an effective diagnostic modality. Study Design/Materials a…Read more
  • Use of an oxygen-carrying blood substitute to improve intravascular optical coherence tomography imaging
    with K. C. Hoang, A. Edris, J. Su, D. S. Mukai, S. Mahon, A. D. Petrov, M. Kern, C. Ashan, Z. Chen, B. J. Tromberg, and J. Narula
    Optical coherence tomography is a catheter-based imaging technology with powerful resolution capable of identifying vulnerable plaques and guiding coronary intervention. However, a significant limitation of intravascular OCT imaging is its attenuation by blood. We propose that the use of an oxygen-carrying blood substitute could potentially optimize OCT image quality. Surgical isolation of the descending thoracic aorta of six rabbits is performed, followed by intravascular OCT imaging of the abd…Read more
  • Noninvasive monitoring of hemodynamic stress using quantitative near-infrared frequency-domain photon migration spectroscopy
    with T. H. Pham, R. Hornung, H. P. Ha, T. Burney, D. Serna, L. Powell, and B. J. Tromberg
    Hemorrhagic hypovolemia and inotropic agent administration were used to manipulate cardiac output and oxygen delivery in rabbits to investigate the correlation between noninvasive frequency domain photon migration spectroscopy and invasive hemodynamic monitoring parameters. Frequency-domain photon migration provides quantitative measurements of light absorption and reduced scattering in tissue. Wavelength dependent μa values were used to calculate in vivo tissue concentration of deoxyhemoglobin …Read more