Manuel Rodriguez

Osteosarcoma is the most common primary bone cancer. According to medical and biological studies, it has a high genetic complexity, thus, to differentiate the mechanisms of appearance and evolution of this disease is a difficult task. In this paper, we use three simplest and well known mathematical models to describe the behavior of several cell lines of osteosarcoma. First, we use a potential law to describe the tumor growth in immunosuppressed mice; with it we show that the variation of tumor growth has a sublinear behavior without the blow-up phenomenon. Second, the logistic model is used to obtain a good aproximation to the rates of proliferation in cell confluency in in vitro experiments. Third, we use a linear reaction-diffusion model; with it, we describe the diffusion behavior for some cell lines. These three models allow us to give a classification of cell lines according to the rates of tumor growth and proliferation and to the diffusion coefficient. A relationship is found between the rates of the tumor growth, the diffusion coefficient and tumorigenicity. Experimental data are extracted from Lauvrak et al. (British Journal of Cancer 109(8):2228–2236, 2013).

Theodor Adorno’s thinking on the essay is an essential part of the recent theoretical development on the essay film. However, the reception of his reflection on the essay in that context does not connect with the breadth of his aesthetic and epistemological thought. This proposal explores how the articulation of his vision of the essay, his philosophy of non-identity, his aesthetic theory and his lesser-known appreciations of cinema contribute other arguments to the understanding of the essay film —in general, of essayistic or audiovisual essay forms— as an aesthetic phenomenon. The connection of The essay as form with other works by Adorno allows us to reconsider his position in relation to the essay and art, to broaden his contributions to make the audiovisual essay intelligible and, in general, some of the most radical aesthetic paths of contemporary cinematography.

Synaesthesia is a condition in which one type of stimulation evokes the sensation of another, as when the hearing of a sound produces photisms, i.e. mental percepts of colours. R is a 20 year old colour blind subject who, in addition to the relatively common grapheme-colour synaesthesia, presents a rarely reported cross modal perception in which a variety of visual stimuli elicit aura-like percepts of colour. In R, photisms seem to be closely related to the affective valence of stimuli and typically bring out a consistent pattern of emotional responses. The present case study suggests that colours might be an intrinsic category of the human brain. We developed an empirical methodology that allowed us to study the subject's otherwise inaccessible phenomenological experience. First, we found that R shows a Stroop effect (delayed response due to interference) elicited by photisms despite the fact that he does not show a regular Stroop with real colours. Secondly, by manipulating the colour context we confirmed that colours can alter R's emotional evaluation of the stimuli. Furthermore, we demonstrated that R's auras may actually lead to a partially inverted emotional spectrum where certain stimuli bring out emotional reactions opposite to the normal ones. These findings can only be accounted for by considering R's subjective colour experience or qualia. Therefore the present paper defends the view that qualia are a useful scientific concept that can be approached and studied by experimental methods.

This text discusses the European system in the modern age, describing the concept of ‘state’ as an object bounded by property rights and its owner’s jurisdiction. In order to maintain the state, it was necessary to keep the inhabitants in a state of submission, through either persuasion or force. State policy consisted in preserving the possessions of the state, improving and increasing it, combining statecraft with the subjects and concert with other state-holders. States were not autonomous units, but domains, and state affairs concerned ways of increasing or maintaining their ownership. When two princes married, they united their states and created a new political and institutional framework, with each spouse taking on the conflicts and alliances of his or her partner, creating entirely new situations. Each peace treaty or alliance was solidly sealed with a dynastic union, as can be seen in the example of the rise of the House of Habsburg, which became the first European power after integrating the inheritances of three great lineages: the Austrian Habsburgs, who contributed fiefdoms and states in Central and Eastern Europe, the House of Burgundy, who contributed states in France and the Low Countries, and the House of Trastámara, who contributed the kingdoms of Castile and Aragon.

The implementation of Distributed Generation may lead to increased pollutant emissions that adversely affect air quality. This work presents a systematic methodology to characterise DG installation in urban basins. First, a set of parameters that characterise a DG implementation scenario is described. Second, a general approach using Geographic Information Systems data is presented. Third, the methodology is demonstrated by application to the South Coast Air Basin of California. Results show that realistic scenarios in the SoCAB concentrate DG technologies nearby industrial zones and introduce pollutant mass increments no larger than 0.43% with respect to baseline emissions. © 2008 Inderscience Enterprises Ltd.

En este artículo nos centraremos en las reflexiones de G. W. Leibniz sobre el problema de la individuación en torno a 1686, principalmente a partir del análisis del Discours de Metaphysique1 y de los textos de la correspondencia que entabló con Arnauld2. Nuestros objetivos principales son, en primer lugar, poner de relieve los principales elementos teóricos que definen la posición leibniziana y, en segundo lugar, atender a la recepción de tales ideas por parte de la filosofía del lenguaje contemporánea, especialmente en lo que respecta a la utilización del principio de individuación de Leibniz como base para una semántica modal.

O presente artigo trata da influência exercida pela filosofia kantiana na actualidade a partir da chamada crise da Modernidade ilustrada. Os autores começam por analisar o posicionamento original kantiano, incidindo especialmente na sua concepção do criticismo e do transcendentalismo. Esta análise é feita a partir da perspectiva da aberta pela Kritik der Urteilskraft enquanto marco do sistema da razão, capaz de incorporar a finitude da mesma. Seguidamente são analisadas a recepção e a transformação do pensamento kantiano a partir de duas correntes filosóficas actuais: o Racionalismo Crítico de Karl Popper e Hans Albert, e a Pragmática Transcendental da linguagem de KarlOtto Apel. Em ambos os casos se compara o seu modo próprio de incorporar as noções de crítica e transcendentalidade com a concepção original de Kant

O presente artigo trata da influência exercida pela filosofia kantiana na actualidade a partir da chamada crise da Modernidade ilustrada. Os autores começam por analisar o posicionamento original kantiano, incidindo especialmente na sua concepção do criticismo e do transcendentalismo. Esta análise é feita a partir da perspectiva da aberta pela Kritik der Urteilskraft enquanto marco do sistema da razão, capaz de incorporar a finitude da mesma. Seguidamente são analisadas a recepção e a transformação do pensamento kantiano a partir de duas correntes filosóflcas actuais: o Racionalismo Crítico de Karl Popper e Hans Albert, e a Pragmática Transcendental da linguagem de Karl-Otto Apel. Em ambos os casos se compara o sen modo próprio de incorporar as noções de crítica e transcendentalidade com a concepção original de Kant. /// The article addresses the influence of Kantian philosophy in contemporary thought from the view point of the crisis of illustrated Modernity. The authors start by analyzing the original Kantian position, whereby particular attention is given to his conception of criticism and transcendentalism. This analysis is worked out from the perspective of the Kritik der Urteilskraft as a frame for the system of reason, able to incorporate the finitude of reason itself This is followed by a detailed analysis of the reception and the transformation of illustrated thinking performed by two contemporary philosophical schools: Critical Rationalism (Karl Popper and Hans Albert), and Transcendental Pragmatics of language (Karl-Otto Apel). The authors of the article compare in each case the adoption of the notions of critique and transcendentality with the original use that Kant himself makes of them.

In this article we will argue that given certain conditions for the evolution of bi- ological controllers, these will necessarily evolve in the direction of incorporating consciousness capabilities. We will also see what are the necessary mechanics for the provision of these capabilities and extrapolate this vision to the world of artifi- cial systems postulating seven design principles for conscious systems. This article was published in the journal Neural Networks special issue on brain and conscious- ness.

In a variety of synaesthesia, photisms result from affect-laden stimuli as emotional words, or faces of familiar people. For R, who participated in this study, the sight of a familiar person triggers a mental image of "a human silhouette filled with colour". Subjective descriptions of synaesthetic experiences induced by the visual perception of people's figures and faces show similarities with the reports of those who claim to possess the ability to see the aura. It has been proposed that the purported auric perception may be easily explained by the presence of a specific subtype of cross-modal perception. We analyse the subjective reports of four synaesthetes who experience colours in response to human faces and figures. These reports are compared with descriptions of alleged auric phenomena found in the literature and with claims made by experts in esoteric spheres. The discrepancies found suggest that both phenomena are phenomenologically and behaviourally dissimilar

Los textos compilados en este libro hablan fundamentalmente de "Leibniz en diálogo", es decir, de Leibniz en su lectura de la tradición, en su confrontación con la filosofía y la ciencia de sus coetáneos; pero también hablan de la recepción y transformación de sus ideas por parte de las corrientes de pensamiento que le siguieron y de este modo se nutrieron de su espíritu intelectual. No pretende esta ser una edición exhaustiva, pero no por ello deja de significar la presente una amplia selección de estudios de ámbito internacional sobre el significado filosófico de Leibniz como pensador abierto, plural y conciliador. Son aquí objeto de estudio las diferentes vías de comunicación entabladas por Leibniz con la tradición, con su época o con la filosofía posterior. Este volumen pretende ser una contribución a la difusión del pensamiento leibniziano entre los profesores y estudiantes de filosofía, a la promoción del debate entre los especialistas y a la mayor consolidación de la comunidad internacional de investigadores sobre Leibniz.

In the long history of interconnectedness between philosophy and literature, the twentieth century was marked, to a large extent, by significant developments in the exploration of ties between phenomenology and theories of reader response and reception. In addition, novel philosophical ideas about time, subjectivity, and consciousness influenced many early- and mid-twentieth century authors, whose innovative and experimental works posed newfangled challenges to readers. Understanding and enjoyment of the experimental texts they produced hinged upon a series of cognitive processes that were considerably more complex than what the nineteenth century literary works used to require.

Studies demonstrating the benefits of ethical behavior at an individual level are scarce. The business ethics literature centers its analysis on unethical behaviors and their consequences, rather than ethical behaviors and their benefits. There is now considerable debate on the role of auditors in society and the function of accounting firms in the free market capitalist system. Specifically, the eminently ethical nature of the auditor’s work has been highlighted. Therefore, the aim of our paper is to show the impact of auditors’ sustained ethical behavior: the trust it generates. This trust results in considerable benefits for the firm due to a reduction in the costs of the partner’s supervision of the auditor. The methodology chosen to validate these claims is a survey of partner of the audit firm in auditing companies. The results of this research confirm the hypotheses raised in the theoretical model.

After compulsory secondary education; many teenagers face the process of choosing a university degree. This process involves uncertainties referred to their personal abilities, interests, social expectations and professional future. The present work is aimed at determining whether the reasons behind the selection of a particular university degree differ depending on the chosen degree. Another objective is determining whether these reasons differ significantly according to gender. The sample comprises 983 students belonging to the area of social and legal sciences at the University of Seville. The obtained results reveal the existence of four main reasons behind the selection of university degrees for which significant gender-related differences were observed: easy degree, job opportunities, high wages and provision of social services. Besides, these seven reasons are observed to differ widely in six of the considered degrees

Recommending the identity of bidders in public procurement auctions has a significant impact in many areas of public procurement, but it has not yet been studied in depth. A bidders recommender would be a very beneficial tool because a supplier can search appropriate tenders and, vice versa, a public procurement agency can discover automatically unknown companies which are suitable for its tender. This paper develops a pioneering algorithm to recommend potential bidders using a machine learning method, particularly a random forest classifier. The bidders recommender is described theoretically, so it can be implemented or adapted to any particular situation. It has been successfully validated with a case study: an actual Spanish tender dataset which has 102,087 tenders from 2014 to 2020 and a company dataset which has 1,353,213 Spanish companies. Quantitative, graphical, and statistical descriptions of both datasets are presented. The results of the case study were satisfactory: the winning bidding company is within the recommended companies group, from 24% to 38% of the tenders, according to different test conditions and scenarios.

El objetivo de este artículo es mostrar qué significa “conocimiento trascendental” en la Crítica de la razón pura de Kant, especialmente a partir de una explicación de las razones por las que este modificó en la segunda edición la definición ofrecida en A 11s. En primer lugar, me centro en la concepción de la ontología de Wolff y Baumgarten, y explico por qué la definición de conocimiento trascendental que Kant ofreció en la primera edición había de resultarle insatisfactoria. En segundo lugar, profundizo en las razones de la corrección introducida por Kant en 1787 (B 25). Sostengo que solo esta última formulación revela la originalidad del conocimiento trascendental con respecto a la ontología de Wolff y Baumgarten, debido a que tal formulación clarifica que el conocimiento trascendental se centra en nuestro tipo específico de conocimiento (unsere Erkenntnißart), frente a la indeterminación de la que, según Kant, adolece la ontología de sus predecesores. Finalmente, planteo una breve discusión crítica sobre la base de estos resultados.

Las familias españolas y occidentales tienen problemas en la comunicación diaria. Esa incomunicación también se da en los distintos niveles del sistema educativo: la ESO, el Bachillerato, la FP y la Universidad. Esto afecta a nuestra juventud entre los 13 y 18 años, que, salvo ejemplos excepcionales, vive desorientada sobre qué quiere hacer con su vida. A pesar de la existencia de orientadores en los centros educativos, la escasez de recursos humanos en esa tarea, unida al obsesivo objetivo por aprobar cursos y la EvAU, está lastrando la formación y orientación de nuestra juventud. Preguntas decisivas que todos nos hacemos a lo largo de la vida u otras que afectan a las relaciones interpersonales, intergeneracionales y sociales no se abordan de frente porque las personas, las familias, los centros educativos, desde los institutos hasta las universidades, y las instituciones administrativas y políticas las están obviando. En este artículo se recurre a las experiencias de vida para reflejar nuestro tiempo, y la necesidad de mejorar los hábitos cotidianos practicando una educación interdisciplinar en formación vocacional, inteligencia emocional y sentimental, educación cívica y moral, formación histórica, instrucción jurídica, educación intergeneracional o en la mirada crítica sobre los medios de comunicación y las redes sociales. La metodología aplicada será la filosofía de la razón vital e histórica y la teoría de las generaciones de Ortega y Gasset y de Julián Marías (Marías, 1961: 1). Además, se recurre a estudios nacionales e internacionales para aportar información, conocimiento y análisis clarificadores.

Edmund Husserl intentó excluir supuestos metafísicos y ajustarse a lo dado en la experiencia inmediata, con el fin de buscar una verdad primera e indubitable sobre la cual basar verdades ulteriores, teóricas. Pero, en la segunda etapa de su pensamiento, él abandonó ese camino para usar, sin tematizarlo, el supuesto subjetivista de René Descartes. Para reconducir la fenomenología al proyecto original de ir a las cosas mismas, eliminando supuestos y ateniéndose a la experiencia inmediata, el lósofo español Antonio González Fernández propone la praxeología. Esta aproximación reemplaza el concepto de sujeto, que considera al ser humano como una cosa pensante, por el de persona, entendida como acto encarnado. Esta definición antropológica, coherente con la visión teológica del ser humano como imagen y semejanza de Dios, posibilita orientaciones éticas de las acciones en pro de la descosificación y dignificación del ser humano y el cuidado de la naturaleza.

A country’s political idiosyncrasies can shape its pandemic response. Both the recent history and the factors that might make governance uncomfortable set the context in which this happens. Among the many causes, stands out the lack of cohesion coming from questioned leaders usually eager to rule. These cravings don’t rely upon political colors and pave the road for spine-chilling mortality just like any demographic vulnerability, e.g. an overaged population or an extreme weather. In the bottom there is a surging thirst for pastoral power that can be traded for such essential things like the life of the ruled ones.

: The aim of this article is to explore the origin of the difficulty of founding the reflecting power of judgment as Kant outlines it in the Preface of the third Critique. Although a foundation for this faculty was only established in 1790, we must interpret it as a critical solution to an old problem, which Kant had already recognized around 1770. Through his comprehension of the meaning of healthy understanding and native wit he already confirms the impossibility of determining the correctness of our judging activity from the use of rules. This approach of the problem must be understood in the context of the controversy about the concept ‘logica naturalis’ in the Leibniz-Wolffian aesthetics and logic. In close conjunction with this tradition, Kant already tries to offer an elucidation of the question of judging through the aesthetics.