Mary Gordon

t is now well accepted that defined architectural compartments within the cell nucleus can regulate the transcriptional activity of chromosomal domains within their vicinity. However, it is generally unclear how these compartments are formed. The nuclear periphery has received a great deal of attention as a repressive compartment that is implicated in many cellular functions during development and disease. The inner nuclear membrane, the nuclear lamina, and associated proteins compose the nuclear periphery and together they interact with proximal chromatin creating a repressive environment. A new study by Harr et al. identifies specific protein–DNA interactions and epigenetic states necessary to re‐position chromatin to the nuclear periphery in a cell‐type specific manner. Here, we review concepts in gene positioning within the nucleus and current accepted models of dynamic gene repositioning within the nucleus during differentiation. This study highlights that myriad pathways lead to nuclear organization.

In this chapter, we explore intersectional perspectives in software engineering by collecting ethnographic histories from three software practitioners from underrepresented groups (URGs). The chapter draws attention to multiple interlocking issues related to diversity and aims to help software engineering researchers and practitioners to become more aware of conscious and unconscious discrimination and to re-story interactions with members of URGs. Without diversity, majoritarian perspectives dominate the software engineering field. This chapter begins with an introduction to intersectionality followed by our research approach, and then three disruptive majoritarian narratives are presented.