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    Oligomeric forms of Aβ peptides are implicated in Alzheimer's disease and disrupt membrane integrity, leading to cytosolic calcium elevation. Proposed mechanisms by which Aβ mediates its effects include lipid destabilization, activation of native membrane channels, and aggregation of Aβ into Ca2+-permeable pores. We distinguished between these using total internal reflection fluorescence microscopy to image Ca2+ influx in Xenopus laevis oocytes. Aβ1-42 oligomers evoked single-channel Ca2+ fluore…Read more