Michael Hughes

These NCCN Guidelines Insights focus on some of the major updates to the 2014 NCCN Guidelines for Thyroid Carcinoma. Kinase inhibitor therapy may be used to treat thyroid carcinoma that is symptomatic and/or progressive and not amenable to treatment with radioactive iodine. Sorafenib may be considered for select patients with metastatic differentiated thyroid carcinoma, whereas vandetanib or cabozantinib may be recommended for select patients with metastatic medullary thyroid carcinoma. Other kinase inhibitors may be considered for select patients with either type of thyroid carcinoma. A new section on "Principles of Kinase Inhibitor Therapy in Advanced Thyroid Cancer" was added to the NCCN Guidelines to assist with using these novel targeted agents.

One longstanding problem for glut theorists is the problem of ‘just true.’ On Beall's conservative version of glut theory advanced in Spandrels of Truth , he addresses the problem in two steps. The first is a rejection of the problem: he claims that the only general notion of ‘just true’ is just truth itself. On that view, the alleged problem of ‘just true’ is reduced to the problem of truth itself, which has a solution—glut theory. The second step is to acknowledge that there is a notion of ‘just true’ which is more limited but nonetheless meets all reasonable criteria demanded by those who advance the longstanding just-true objection. Marcus Rossberg disagrees. According to Rossberg, a just-true operator ought to iterate and be non-arbitrary in ways that Beall's proposed just-true operator is not. My aim in this paper is to construct a new conditional in terms of which a new just-true operator may be defined, a necessity operator, and to show that it meets all of the target desiderata of the debate. I then use that new operator to address the arbitrariness worries raised by Rossberg