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45Are nicotinic acetylcholine receptors coupled to G proteins?Bioessays 35 (12): 1025-1034. 2013.It was, until recently, accepted that the two classes of acetylcholine (ACh) receptors are distinct in an important sense: muscarinic ACh receptors signal via heterotrimeric GTP binding proteins (G proteins), whereas nicotinic ACh receptors (nAChRs) open to allow flux of Na+, Ca2+, and K+ ions into the cell after activation. Here we present evidence of direct coupling between G proteins and nAChRs in neurons. Based on proteomic, biophysical, and functional evidence, we hypothesize that binding t…Read more
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43Are nicotinic acetylcholine receptors coupled to G proteins?Bioessays 35 (12): 1025-1034. 2013.It was, until recently, accepted that the two classes of acetylcholine (ACh) receptors are distinct in an important sense: muscarinic ACh receptors signal via heterotrimeric GTP binding proteins (G proteins), whereas nicotinic ACh receptors (nAChRs) open to allow flux of Na+, Ca2+, and K+ ions into the cell after activation. Here we present evidence of direct coupling between G proteins and nAChRs in neurons. Based on proteomic, biophysical, and functional evidence, we hypothesize that binding t…Read more
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York UniversityUndergraduate
Toronto, Ontario, Canada
Areas of Interest
Philosophy of Mind |
Philosophy of Cognitive Science |