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    Human-specific regulation of MeCP2 levels in fetal brains by microRNA miR-483-5p
    with K. Han, V. A. Gennarino, Y. Lee, K. Pang, K. Hashimoto-Torii, S. Choufani, C. S. Raju, M. C. Oldham, R. Weksberg, Z. Liu, and H. Y. Zoghbi
    Proper neurological function in humans requires precise control of levels of the epigenetic regulator methyl CpGbinding protein 2. MeCP2 protein levels are low in fetal brains, where the predominant MECP2 transcripts have an unusually long 39 untranslated region. Here, we show that miR-483-5p, an intragenic microRNA of the imprinted IGF2, regulates MeCP2 levels through a human-specific binding site in the MECP2 long 39 UTR. We demonstrate the inverse correlation of miR-483-5p and MeCP2 levels in…Read more
  • Development of the cortex
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  • Cortical development and evolution
    Brain and Mind: Evolutionary Perspectives. forthcoming.