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    Effects of combined photodynamic therapy and ionizing radiation on human glioma spheroids
    with S. J. Madsen, C. H. Sun, B. J. Tromberg, A. T. Yeh, and H. Hirschberg
    The effects of combined photodynamic therapy and ionizing radiation are studied in a human glioma spheroid model. The degree of interaction between the two modalities depends in a complex manner on factors such as PDT irradiation fluence, fluence rate and dose of ionizing radiation. It is shown that gamma radiation and PDT interact in a synergistic manner only if both light fluence and gamma radiation dose exceed approximately 25 J cm -2 and 8 Gy, respectively. Synergistic interactions are obser…Read more