• Integrin α9 on lymphatic endothelial cells regulates lymphocyte egress
    with K. Ito, J. Morimoto, A. Kihara, Y. Matsui, D. Kurotaki, M. Kanayama, M. Ishii, D. Sheppard, A. Takaoka, and T. Uede
    Sphingosine 1-phosphate plays a role in lymphocyte egress from lymphoid organs. However, it remains unclear how S1P production and secretion are regulated. We show that under inflammatory conditions, α9 integrin, which is closely associated with activated β1 integrin, and its ligand, tenascin-C, colocalize on medullary and cortical sinuses of draining lymph nodes, which is a gate for lymphocyte exit, and that inhibition of lymphocyte egress is evident by blockade of α9 integrin-mediated signalin…Read more