Sara O'Donnell

This essay explores the conceptual and philosophical complexities surrounding ayahuasca use, focusing on its ability to reveal ghosts through the lens of hauntology. Ayahuasca, a psychoactive brew traditionally used in shamanic rituals, is known to evoke profound experiences involving spirits, mystical entities, and transformative states of consciousness. The brew's active compound, dimethyltryptamine (DMT), is notable for its dual nature as both an endogenous neurotransmitter and an exogenous psychedelic. This duality unsettles the boundary between what is natural to the human body and what is external, inviting a reconsideration of anthropocentric and biomedical assumptions. Furthermore, encounters with discarnate beings during ayahuasca journeys blur the lines between corporeality and incorporeality, suggesting that these entities—while phenomenologically real—defy categorization within traditional ontological frameworks. Ultimately, we argue that ayahuasca's spectral residues disrupt materialist understandings of reality, leaving traces that haunt these models and invite broader reflections on consciousness, interconnection, death, and metaphysical limits. By listening to these ghosts, both as conceptual provocations and as subjective experiences, we can challenge and expand our understanding of reality while embracing the transformative and scary possibilities ayahuasca presents.