Shifa Zhao

© 2015 Elsevier Inc..Emerging evidence demonstrates that the DNA repair kinase DNA-PKcs exerts divergent roles in transcriptional regulation of unsolved consequence. Here, invitro and invivo interrogation demonstrate that DNA-PKcs functions as a selective modulator of transcriptional networks that induce cell migration, invasion, and metastasis. Accordingly, suppression of DNA-PKcs inhibits tumor metastases. Clinical assessment revealed that DNA-PKcs is significantly elevated in advanced disease and independently predicts for metastases, recurrence, and reduced overall survival. Further investigation demonstrated that DNA-PKcs in advanced tumors is highly activated, independent of DNA damage indicators. Combined, these findings reveal unexpected DNA-PKcs functions, identify DNA-PKcs as a potent driver of tumor progression and metastases, and nominate DNA-PKcs as a therapeutic target for advanced malignancies. Goodwin etal. identify DNA-PKcs as a promising therapeutic target that drives prostate cancer progression and metastasis through transcriptional regulation. DNA-PKcs is significantly elevated in advanced disease and is an independent predictor of metastasis, recurrence, and poor survival.

With the development of globalization and its inner-contradictions exposing gradually, a new anti-globalization movement has sprung up Since 1990s. It is also a kind of new globalization. In fact, contemporary globalization is controlled by capitalism. During the course, capitalist contradictions and crisis also globalize. Anti-globalization exposes the new crisis of contemporary capitalism The substance of contemporary antiglobalization is to opposite capitalism and its crisis. It is not a mature movement now, but it is significant to correct the developing direction of contemporary globalization.