-
© 2015 American Neurological Association. Objective Mutations in the gene encoding the prion protein are responsible for approximately 10 to 15% of cases of prion disease in humans, including Creutzfeldt-Jakob disease. Here, we report on the discovery of a previously unreported C-terminal PrP mutation in a CJD patient exhibiting a disease similar to the rare VV1 subtype of sporadic CJD and investigate the role of this mutation in prion replication and transmission. Methods We generated transgeni…Read more
Cambridge, United Kingdom of Great Britain and Northern Ireland
Areas of Specialization
1 more
Animal Ethics |
Philosophy of Consciousness |
Philosophy of Cognitive Science |
Comparative Psychology |
Animal Mind Sciences, Misc |
Animal Captivity |