Silvia Gonzalez

Cryopreservation‐enabled workflows decouple tissue acquisition from organoid generation, allowing archived biopsies and surgical explants to be revisited as renewable experimental models. This shift expands access to patient‐specific material, reduces the logistical and batch variability inherent in fresh‐tissue pipelines, and enables retrospective and longitudinal studies anchored in real‐world clinical cohorts. Proof‐of‐concept studies show that liver organoids can be derived from cryopreserved human tissues that retain viability and disease‐relevant phenotypes, but performance remains sensitive to the source material, culture lines, and protocol details. The field remains fragmented, lacking broadly adopted standard operating procedures, shared post‐thaw quality benchmarks, and interoperable data infrastructures linking organoid biobanks to clinical metadata.In this work, we argue that cryopreservation‐enabled organoid biobanking should be treated as foundational infrastructure for precision hepatology, and we outline a pragmatic roadmap for coordinated implementation over the next decade.

In this work, we introduce families of multimodal maps based on logistic map, i.e., families of m-modal maps are defined on an interval I ⊂ ℝ, which is partitioned into non-uniform subdomains, with m ∈ ℕ. Because the subdomains of the partition are not uniform, each subdomain contains a unimodal map, given by the logistic map, that can have different heights. Therefore, we give the necessary and sufficient conditions for these modal maps present a multimodal family of m-modal maps, i.e., a bifurcation parameter can set a unimodal map, a bimodal map, up to a m -modal map. Some numerical examples are given according to the developed theory. Some numerical examples are given in accordance with the developed theory.

En el trabajo se propone difundir la teoría y los enfoques referidos a la ciencia de la sostenibilidad, con especial énfasis en el contexto académico cubano, al relacionar su emergencia a las urgencias que surgen en los vínculos entre la ciencia, la naturaleza y la sociedad, así como mostrar las articulaciones de la Ciencia de la Sostenibilidad con la política científica, la educación universitaria y la salud pública. In this paper, the theory and the approaches of the science of sustainability is promoted. Special emphasis is put on the academic Cuban context, when relating its emergence to the urgencies that appear within the links among science, nature and society. The interconnections of the science of sustainability with the scientific policy, the university education and the public health is shown as well as