Seattle, Washington, United States of America
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    LL-37 attenuates inflammatory impairment via mTOR signaling-dependent mitochondrial protection
    with W. Sun, Y. Zheng, Z. Lu, H. Wang, Z. Feng, J. Wang, F. Liu, and J. Liu
    The human cationic antimicrobial protein LL-37 is a multifunctional host defense peptide with a wide range of immunomodulatory activities. Previous work has shown that LL-37 exerts both pro- and anti-inflammatory effects. The role of mitochondria in the skin inflammatory effects of LL-37 has not been well studied. Therefore, our aim was to investigate the immunomodulatory effect of LL-37 in HaCaT cells and to delineate the underlying mechanisms related to mitochondrial function. Immunohistochemi…Read more