Surya Prakash

© 2014 Sangeetha Prakash et al.Chlamydophila pneumoniae is a common respiratory pathogen that causes a chronic and persistent airway infection. The elderly display an increased susceptibility and severity to this infection. However, the underlying mechanisms are not well understood. Dendritic cells are the initiators and regulators of immune responses. Therefore, we investigated the role of DCs in the age-associated increased CPn infection in vitro in humans. Though the expression of activation markers was comparable between the two age groups, DCs from aged subjects secreted enhanced levels of proinflammatory mediators such as TNF-α and CXCL-10 in response to CPn. In contrast, the secretion of IL-10 and innate interferons, IFN-α and IFN-, was severely impaired in DCs from aged donors. The increased activation of DCs from aged subjects to CPn also resulted in enhanced proliferation of CD4 and CD8 T cells in a DC-T coculture. Furthermore, T cells primed with CPn-stimulated DCs from aged subjects secreted increased levels of IFN-γ and reduced levels of IL-10 compared to DCs obtained from young subjects. In summary, DCs from the elderly displayed enhanced inflammatory response to CPn which may result in airway remodeling and increase the susceptibility of the elderly to respiratory diseases such as asthma.

Individuals across organizations and roles are increasingly seeking a meaningful and fulfilling experience in their activities. Towards that, the Bhagavad Gita advises the practice of Karma Yoga. However, the conceptualization of Karma Yoga in extant management literature is shrouded in confusion with little agreement on its dimensionalities. In this article, employing qualitative method, we offer an alternative conceptualization of the construct. Accordingly, we define Karma Yoga as a persistent positive state of mind that is characterized by absorption and service consciousness. Furthermore, the findings also suggest the importance of sense control and equanimity as the necessary prerequisites for individuals to practise Karma Yoga.